Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer.

Abstract:

:In a prospective multicenter study, 186 patients with squamous cell esophageal carcinoma, who after evaluation were considered suitable for surgery, were randomized to 4 treatment groups: Group 1, surgery alone; Group 2, pre-operative chemotherapy (cisplatin and bleomycin) and surgery; Group 3, pre-operative irradiation (35 Gy) and surgery; Group 4, pre-operative chemotherapy, radiotherapy, and surgery. Three-year survival was significantly higher in the pooled groups receiving radiotherapy as compared with the pooled groups not receiving radiotherapy. Comparison of the groups having pre-operative chemotherapy with those not having chemotherapy showed no significant difference in survival. Female patients had a significantly better survival than males. The results indicate that pre-operative irradiation had a beneficial effect on intermediate term survival, whereas the chemotherapy regime used did not influence survival.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Nygaard K,Hagen S,Hansen HS,Hatlevoll R,Hultborn R,Jakobsen A,Mäntyla M,Modig H,Munck-Wikland E,Rosengren B

doi

10.1007/BF02067069

keywords:

subject

Has Abstract,Author List Incomplete

pub_date

1992-11-01 00:00:00

pages

1104-9; discussion 1110

issue

6

eissn

0364-2313

issn

1432-2323

journal_volume

16

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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