Abstract：
:Secretin is a stimulator of both endocrine and exocrine secretions of the pancreas, and we aimed to evaluate its effects on splanchnic blood flow in rats with a microsphere technique. Anesthetized rats were infused with secretin (0.5 or 2.0 micrograms/kg body weight/hr) for 10 minutes. Some animals were normoglycemic, whereas other received a glucose injection 3 minutes before blood flow measurements. Secretin did not affect serum insulin concentrations in normoglycemic animals but consistently led to higher insulin concentrations in the hyperglycemic rats. Total pancreatic blood flow was increased by the highest secretin dose in normoglycemic animals, whereas no effects were seen in the hyperglycemic rats. Administration of glucose caused a pronounced increase in islet and fractional islet blood flow in saline-infused animals. Secretin affected neither islet nor fractional blood flow in normoglycemic or hyperglycemic rats. Glucose administration increased duodenal blood flow in animals infused with saline and both duodenal and colonic blood flow in rats given the lowest dose of secretin. No effects on either colonic or duodenal blood perfusion were seen in animals infused with the highest dose of secretin. Secretin mainly affects blood flow to the whole pancreas and not that of the islets. Furthermore, glucose-induced insulin release can be achieved without a simultaneous increase in islet blood flow; that is these two events may be dissociated from one another.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Carlsson PO,Jansson Ldoi
10.1007/s00268-001-0037-0keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
835-9issue
7eissn
0364-2313issn
1432-2323journal_volume
25pub_type
杂志文章abstract：INTRODUCTION:The association between socioeconomic status (SES) and relative survival of rectal cancer is little investigated. We hypothesized that the impact on risk of death by SES would be much smaller when differences in background mortality (comorbidity, lifestyle factors) were taken into account, i.e. in modellin...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2735-4
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:The change in the route of food passage after pancreaticoduodenectomy (PD) is quite similar to the change after gastric bypass surgery; both procedures bypass the duodenum and directly connect to the distal jejunum. Moreover, both procedures result in resolution of type 2 diabetes mellitus. Therefore, more d...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3157-7
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Congenital diaphragmatic hernia (CDH) continues to be associated with significant mortality and morbidity rates despite advances in neonatal care. Fetal intervention for CDH has been studied for 25 years. After initial difficulties encountered with open fetal repair, attention has turned to tracheal occlusio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9074-7
更新日期：2007-08-01 00:00:00
abstract：:To clarify the clinical significance of the status of surgical margins, especially the dissected margin in the transverse direction, a clinicopathologic study was performed on 60 patients with carcinoma of the bile duct who underwent radical resection. The patients in group A (n = 28) had no cancer invasion within 5 m...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00298931
更新日期：1994-09-01 00:00:00
abstract：:Cancers of the distal rectum (less than 7.5 cm from the anal verge) that are freely mobile, moderately well or well differentiated, less than 4 cm in size, limited to the bowel wall, and without evidence of metastasis should be considered candidates for treatment with electrocoagulation for cure. Tumor cell ploidy and...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02104447
更新日期：1992-05-01 00:00:00
abstract：:The expression CA195 in serum, defined by monoclonal antibody CC3C195 (IgM), was studied in 67 patients with pancreatic cancer and in 138 patients with biliary or pancreatic benign disease. The results were compared with carcinoembryonic antigen (CEA) expression. The overall sensitivity of the CA195 assay (> 12 U/ml) ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00013182
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:Solitary fibrous tumor of the pleura (SFTP) represents a clinical entity rarely encountered, especially in giant forms. Complete surgical resection for giant tumor of pleura is a challenge. The aim of this article is to present five new cases of giant SFTP, and to discuss their clinical characteristics and t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0715-x
更新日期：2010-11-01 00:00:00
abstract：:Innovation is responsible for most advances in the field of surgery. Innovative approaches to solving clinical problems have significantly decreased morbidity and mortality for many surgical procedures, and have led to improved patient outcomes. While innovation is motivated by the surgeon's expectation that the new a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2568-1
更新日期：2014-07-01 00:00:00
abstract：:This study investigated whether cytokines and colony-stimulating factors can predict prognosis in patients with postoperative multiple organ failure (MOF). We evaluated 14 patients with postoperative MOF who underwent operation for cardiovascular disease. Seven patients recovered from MOF (survivors) and seven did not...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900520
更新日期：1998-10-01 00:00:00
abstract：:The effects of pneumoperitoneum on the lower esophageal sphincter (LES) were evaluated during laparoscopic operation for esophageal achalasia. Intraoperative manometry was performed in three patients who underwent laparoscopic cardiomyectomy with Dor's fundoplication and five patients who underwent laparoscopic cholec...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900146
更新日期：1996-10-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to describe the perioperative and long-term results of carotid endarterectomy (CEA) in patients aged 60 or less and compare them to patients of more advanced age in a retrospective single-centre case-control study. METHODS:From January 1996 to December 2014, 5893 consecutive CEAs wer...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4133-1
更新日期：2018-01-01 00:00:00
abstract：:Open gastric surgery in elderly patients is associated with higher morbidity and mortality rates than those reported among younger individuals. Therefore, minimally invasive surgery may have a larger impact on the elderly compared to the younger age group. The objective of this study was to evaluate the experience of ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0208-5
更新日期：2005-12-01 00:00:00
abstract：:Quality of life is an important outcome measure following surgery for ulcerative colitis. Quality of life incorporates not only the physical or functional outcome; it also considers the emotional and social well-being of patients. Quality of life may be measured using disease-specific or generic quality of life measur...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900400
更新日期：1998-04-01 00:00:00
abstract：:The imaging characteristics of diagnostic ultrasound (US) are determined by the ultrasonic properties of tissue. The velocity of propagation of US and the attenuation are the 2 most important parameters. These determine the frequency with which the tissues may be imaged, which in turn sets a fundamental limit on the a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910026
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Management of critically ill patients is challenging in a low-resource setting. In Rwanda, peritonitis is a common surgical condition where patients often present late, with advanced disease. We aim to describe critical care management of patients with peritonitis in Rwanda. METHODS:Data were collected at a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4598-6
更新日期：2018-10-01 00:00:00
abstract：:A new endoprosthesis designed for surgical intubation of neoplastic strictures of the proximal biliary tract has been developed. The technical aspects of intubation by this endoprosthesis are discussed, and the results in the first 25 patients are given. The results suggest that this device was well tolerated. Mortali...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01671165
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Although 18F-fluorodeoxyglucose (FDG) positron emission tomography combined with computed tomography (PET/CT) is a potentially powerful, non-invasive imaging tool in differentiating adrenal metastasis from benign disease, some adenomas also exhibit high FDG uptake, therefore mimicking metastasis (i.e., false...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3035-3
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:There is no standardized treatment for patients with chemo-resistant or recurrent advanced ovarian cancer. Locoregional treatments combining cytoreductive surgery and intraperitoneal chemohyperthermia (HIPEC) may improve survival for locoregional disease. PATIENTS AND METHODS:A prospective single center study ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9146-8
更新日期：2007-09-01 00:00:00
abstract：:The role of nitric oxide in mediating smooth muscle relaxation is well established. Less is known about the downstream signaling events inside the smooth muscle cell that produce relaxation of the contractile machinery. One possible effector molecule is the small heat shock protein HSP20. Increased phosphorylation of ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-002-4052-6
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Teamwork is fundamental to effective surgery, yet there are currently no measures of teamwork to guide training, evaluate team interventions or assess the impact of teamwork on outcomes. We report the first steps in the development of an observational assessment of teamwork and preliminary findings. METHOD:...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0488-9
更新日期：2006-10-01 00:00:00
abstract：:A group of 105 consecutive patients with venographically proved major acute deep vein thrombosis (DVT) were randomized in an open prospective study to evaluate the comparative efficacy and safety of a fixed dose of subcutaneous low-molecular-weight heparin (LMWH) and warfarin for the prevention of recurrent venous thr...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002689900081
更新日期：1996-06-01 00:00:00
abstract：:Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. However, to our best knowledge, at least 163 cases of functioning parathyroid carcinoma appeared in the English literature from 1981 to 1989. We summarize the available information obtained from the reports of those patients and compare it with prev...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01665308
更新日期：1991-11-01 00:00:00
abstract：OBJECTIVES:We report three cases of isolated infrarenal aortic dissecting aneurysms managed with stent-graft. MATERIALS AND METHODS:Three patients, two men and one woman, with a mean age at diagnosis of 69 years were identified. In all cases, chest CT-A did not reveal evidence of thoracic aortic dissection. The mean m...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0704-7
更新日期：2006-07-01 00:00:00
abstract：:Treacher Collins Syndrome is a rare bilateral congenital deformity occurring in 1 in 10,000 births. It is also known, in the European literature, as Franceschetti Syndrome, and is additionally known as mandibulofacial dysostosis. It is a syndrome with a very wide spectrum of manifestations characterized by distortions...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01660753
更新日期：1989-07-01 00:00:00
abstract：:This prospective study was instituted to assess whether the use of the on-pump method or the off-pump method affects changes in health-related quality of life (QOL) as evaluated a year after coronary artery bypass graft (CABG) surgery. Data including preoperative risk factors and postoperative morbidity up to discharg...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7486-1
更新日期：2004-10-01 00:00:00
abstract：INTRODUCTION:Acute intestinal ischemia is in most cases a lethal condition with a low survival rate. Risk factors of perioperative mortality are poorly defined. The aim of this study was to define risk factors that predict an adverse outcome of acute mesenteric ischemia (AMI). METHODS:A total of 132 consecutive patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0560-5
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Patients with end-stage renal disease (ESRD) and secondary hyperparathyroidism (SHPT) are at high risk of mortality. Whether an increased risk of death persists after a parathyroidectomy (PTX) is not clearly established. SUBJECTS AND METHODS:The survival of 40 patients with ESRD and SHPT who underwent PTX w...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0693-1
更新日期：2007-05-01 00:00:00
abstract：:Mesosigmoidoplasty is a nonresective procedure for nongangrenous sigmoid volvulus. It aims to correct the main pathogenetic factor of this condition, the narrow but long mesosigmoid. Although it had been demonstrated by intraoperative measurements that this has indeed achieved its purpose, recurrent volvulus has been ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7010-z
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Pulmonary large cell neuroendocrine carcinoma (LCNEC) is pathologically classified as non-small-cell lung cancer (NSCLC), but its clinical behavior is more aggressive than other types of NSCLC. Accordingly, the optimal treatment strategy for LCNEC, including the indication of adjuvant treatment, remains cont...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3908-8
更新日期：2017-07-01 00:00:00
abstract：:With limited resources and the current concerns about using animals for research purposes, the needs must be clear when setting up trauma and sepsis experiments for pharmacologic interventions. Such interventions are performed typically for four reasons: (1) to study the pathophysiologic role of certain mediators (whi...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900077
更新日期：1996-05-01 00:00:00
