Stress and vascular disease at the cellular and molecular levels.

Abstract:

:The role of nitric oxide in mediating smooth muscle relaxation is well established. Less is known about the downstream signaling events inside the smooth muscle cell that produce relaxation of the contractile machinery. One possible effector molecule is the small heat shock protein HSP20. Increased phosphorylation of HSP20 is associated with vasorelaxation. HSP20 is associated with elements of the contractile machinery such as another small heat shock protein (HSP27), actin, and myosin. Thus HSP20 may mediate vasorelaxation by directly modulating cytoskeletal or contractile elements in muscle cells.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Brophy CM

doi

10.1007/s00268-002-4052-6

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

779-82

issue

7

eissn

0364-2313

issn

1432-2323

journal_volume

26

pub_type

杂志文章,评审
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    更新日期:2003-06-01 00:00:00

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    journal_title:World journal of surgery

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    更新日期:2006-04-01 00:00:00

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    更新日期:1997-06-01 00:00:00

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    authors: Palanivelu C,Rangarajan M,John SJ

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    doi:10.1007/BF01658415

    authors: Gravelle IH,Lyons K

    更新日期:1989-11-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章

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    authors: Patel SP,Lee JS,Ranney DN,Al-Holou SN,Frost CM,Harris ME,Lewin SA,Liu E,Madenci A,Majkrzak AA,Nelson J,Peterson SF,Serecky KA,Wilkinson DA,Wojcik BM,Englesbe MJ,Lynch RJ

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    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

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    pub_type: 杂志文章,评审

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  • Nonoperative Management of Blunt Splenic Trauma in Patients with Traumatic Brain Injury: Feasibility and Outcomes.

    abstract:INTRODUCTION:Preventing secondary insult to the brain is imperative following traumatic brain injury (TBI). Although TBI does not preclude nonoperative management (NOM) of splenic injuries, development of hypotension in this setting may be detrimental and could therefore lead trauma surgeons to a lower threshold for op...

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    更新日期:2018-08-01 00:00:00

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  • Open Mesh Repair for Inguinal Hernia is Safer than Laparoscopic Repair or Open Non-mesh Repair: A Nationwide Registry Study of Complications.

    abstract:BACKGROUND:Inguinal hernia repair is the most common elective procedure in general surgery. Therefore, the number of patients having complications related to inguinal hernia surgery is relatively large. The aim of this study was to compare complication profiles of inguinal open mesh (OM) hernioplasties with open non-me...

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  • Implementation of the World Health Organization Trauma Care Checklist Program in 11 Centers Across Multiple Economic Strata: Effect on Care Process Measures.

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    authors: Lashoher A,Schneider EB,Juillard C,Stevens K,Colantuoni E,Berry WR,Bloem C,Chadbunchachai W,Dharap S,Dy SM,Dziekan G,Gruen RL,Henry JA,Huwer C,Joshipura M,Kelley E,Krug E,Kumar V,Kyamanywa P,Mefire AC,Musafir M,

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