Abstract:
BACKGROUND:Postoperative ileus is a common problem with significant clinical and economic consequences. We hypothesized that Gastrografin may have therapeutic utility by accelerating the recovery of postoperative ileus after colorectal surgery. The aim of this trial was to study the impact of oral Gastrografin administration on postoperative prolonged ileus (PPI) after elective colorectal surgery. METHODS:The main endpoint of this randomized, double-blinded, controlled trial was time of resolution of PPI. The secondary endpoints were overall hospital length of stay, time to start oral intake, time to first passage of flatus or stools, time of need of nasogastric tube, and need of parenteral nutrition. Included criteria were patients older than 18 years, operated for colonic neoplasia, inflammatory bowel disease, or diverticular disease. There were two treatments: Gastrografin administration and placebo. The sample size was calculated taking into account the average length of postoperative ileus after colorectal resection until tolerance to oral intake. Statistical analysis showed that 29 subjects in each group were needed. RESULTS:Twenty-nine patients per group were randomized. Groups were comparable for age, gender, ASA Physical Status Classification System, stoma construction, and surgical technique. No statistical differences were observed in mean time to resolution between the two groups, 9.1 days (CI 95%, 6.51-11.68) in Gastrografin group versus 10.3 days (CI 6.96-10.29) in Placebo group (P = 0.878). Even if not statistically significant, time of resolution of PPI, overall length of stay, time of need of nasogastric tube, and time to tolerance of oral intake were shorter in the G group. CONCLUSIONS:Gastrografin does not accelerate significantly the recovery of prolonged postoperative ileus after elective colorectal resection when compared with placebo. However, it seems to clinically improve all the analyzed variables.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Biondo S,Miquel J,Espin-Basany E,Sanchez JL,Golda T,Ferrer-Artola AM,Codina-Cazador A,Frago R,Kreisler Edoi
10.1007/s00268-015-3260-9subject
Has Abstractpub_date
2016-01-01 00:00:00pages
206-14issue
1eissn
0364-2313issn
1432-2323pii
10.1007/s00268-015-3260-9journal_volume
40pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Thymic epithelial tumors are characterized by slow growth and variable malignant behavior. We present our experience on the surgical management of these tumors. MATERIALS AND METHODS:We conducted a retrospective analysis of patients with thymomas undergoing modified maximal thymectomy over a period of 16 ye...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0097-0
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abstract:BACKGROUND:Laparoscopic rectal resection (LRR) for cancer is a challenging procedure, with conversion to open surgery being reported in up to 30% of cases. Since only a few studies with short follow-up have compared converted LRR and open RR (ORR), it is unclear if conversion to open surgery should be prevented by pref...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4614-x
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abstract::The well-known poor prognosis of proximal bile duct cancer is due to its unfortunate anatomical location and its late diagnosis. Successful tumor resection, which is considered to be optimal treatment, depends on many factors. Eighty-eight patients suffering from proximal bile duct cancer underwent surgical exploratio...
journal_title:World journal of surgery
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abstract:BACKGROUND:In the last decade, robotic video-assisted thoracic surgery (R-VATS) has grown significantly and consolidated as an alternative to video-assisted thoracic surgery. The objective of this study is to present the implementation as well as the experience with R-VATS accumulated by 2 Brazilian groups. We also com...
journal_title:World journal of surgery
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abstract:BACKGROUND:The aim of the study was to compare the changes in health-related quality of life (QOL) after lung surgery between young and old patients. METHODS:We performed a prospective, population-based, cohort study to investigate health-related QOL before and 6 months after lung surgery. We used the validated instru...
journal_title:World journal of surgery
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journal_title:World journal of surgery
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journal_title:World journal of surgery
pub_type: 杂志文章,已发布勘误
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abstract:INTRODUCTION:Response rates to systemic chemotherapy for patients who have failed irinotecan-based chemotherapy for liver-dominant metastatic colorectal cancer range between 10 and 18 % with overall survival between 7 and 9 months. The aim of this study was to assess the efficacy and safety of hepatic arterial irinotec...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
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abstract::The aim of the present study was to determine whether patients with the incident hospital diagnosis of primary hyperparathyroidism (PHPT) in Denmark during the period 1977-1993 had an increased mortality from cardiovascular disease and cancer compared to the rest of the Danish population. In a random sample of half of...
journal_title:World journal of surgery
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journal_title:World journal of surgery
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abstract::Among 26 patients with gallbladder carcinoma, 11 resected cases were studied retrospectively with respect to the preoperative imaging techniques and the operative procedures employed. Ultrasonography, endoscopic ultrasonography, and computed tomography were valuable in detecting gallbladder carcinoma preoperatively wh...
journal_title:World journal of surgery
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journal_title:World journal of surgery
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abstract:BACKGROUND:The most important problem in pancreatic fistula is whether one can distinguish clinical pancreatic fistula, grade B + C fistula by the International Study Group on Pancreatic Fistula (ISGPF), from transient pancreatic fistula (grade A), in the early period after pancreaticoduodenectomy (PD). It remains uncl...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0220-2
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Venous thromboembolism (VTE) is a condition that has always been perceived to be rare in Asia. The aim of this systematic review was to gather the current available evidence on the incidence of VTE in this population. A secondary aim was to assess the efficacy of pharmacological prophylaxis, and hence determ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:This study was undertaken to determine the efficacy of the clinical indications for performing staging laparoscopy for locally advanced gastric cancer to detect peritoneal metastasis or positive cytology findings. METHODS:The study included 231 patients with T4 gastric cancer without hematogenous or clinica...
journal_title:World journal of surgery
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doi:10.1007/s00268-011-1290-5
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-001-0187-0
更新日期:2002-01-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900283
更新日期:1997-07-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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更新日期:1989-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2237-9
更新日期:2014-01-01 00:00:00
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journal_title:World journal of surgery
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更新日期:2018-02-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2078-6
更新日期:2013-09-01 00:00:00
abstract::Surgical exposure of the recurrent laryngeal nerve decreases the incidence of nerve injuries during thyroid surgery. Intraoperative neuromonitoring was introduced to facilitate identification and protection of the recurrent laryngeal nerve. Between February 1996 and June 2002 a total of 288 patients underwent thyroid ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-004-7226-6
更新日期:2004-06-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00