Prognostic significance of vascular endothelial growth factor D in gastric carcinoma.

Abstract:

:The angiogenic factor called vascular endothelial growth factor (VEGF)-D is a ligand for VEGF receptor-2 (VEGFR-2/KDR) and receptor-3 (VEGFR-3/Flt-4). It is implicated in the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to investigate the prognostic significance of VEGF-D expression in patients with gastric carcinoma. We assessed the expression of VEGF-D in gastric carcinoma by immunohistochemistry on 143 consecutive patients' stored sections and evaluated the lymphatic vessel count (LVC) in tumors using the novel selective lymphatic endothelium marker D2-40. VEGF-D expression was observed in 55 (39%) tumor sections. The expression of VEGF-D correlated significantly with tumor size, T of the TNM classification, lymphatic and venous system invasion, LVC, lymph node metastasis, M of TNM, and pTNM stage. Multivariate analysis indicated that VEGF-D expression was an independent prognostic factor for both relapse-free survival (RFS) and overall survival (OS). Our data indicate the involvement of VEGF-D in tumor progression via lymphoangiogenic pathways. Practically, VEGF-D expression can be useful for predicting RFS and OS in patients with gastric carcinoma.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Shida A,Fujioka S,Ishibashi Y,Kobayashi K,Nimura H,Mitsumori N,Suzuki Y,Kawakami M,Urashima M,Yanaga K

doi

10.1007/s00268-005-0076-z

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1600-7

issue

12

eissn

0364-2313

issn

1432-2323

journal_volume

29

pub_type

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