Abstract:
BACKGROUND:Breast cancer in young women is uncommon, but when it does occur it has been reported to have aggressive biological characteristics. The incidence of breast cancer peaks at age 40 in Hong Kong Chinese women, earlier than in Caucasians. This study is the first to report the tumor characteristics and management of breast cancer in Chinese women younger than age 40 and a comparison with their older counterparts. MATERIALS AND METHODS:Demographic and clinicopathologic findings of 1,485 Chinese women with breast cancer seen during the period September 2003 to November 2006 were prospectively recorded, and comparisons were made between those who were under the age of 40 and those 40 years of age and older. These results were then compared with a reference population obtained from the Surveillance, Epidemiology and End Results (SEER) database between 2003 and 2004. RESULTS:17.6% of the women were younger than 40 years old, and age distribution was significantly different from women in the SEER database. The mean age at menarche was lower in women under age 40 (p < 0.0005), and age at first live birth was also higher (p = 0.017). The rate of first detection by screening mammography was significantly higher among women who were 40 of age and older (p = 0.002). Breast conservation surgery was more commonly performed in the younger age group of Chinese women, particularly when tumor size was less than 2 cm (p = 0.001). A significantly higher proportion of women under age 40 had breast reconstruction (p < 0.001). The majority of women presented with stage 0-II disease, but in the Chinese groups the younger patients presented at a later stage (p = 0.04). Younger women had higher pathological grade and poorly differentiated tumors (p = 0.02), more nodal involvement (p = 0.024), and lymphovascular permeation involvement (p < 0.001). The majority of tumors were ER and PR positive in both groups, but younger women had a higher proportion of cerbB2-positive tumors. CONCLUSION:Chinese women present with breast cancer at an earlier age. Younger women present with more advanced disease and more aggressive tumor characteristics. More ethnic-specific screening protocols and treatment decisions may benefit this group of patients.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Kwong A,Cheung P,Chan S,Lau Sdoi
10.1007/s00268-008-9589-6subject
Has Abstractpub_date
2008-12-01 00:00:00pages
2554-61issue
12eissn
0364-2313issn
1432-2323journal_volume
32pub_type
杂志文章abstract::The prognosis of patients who undergo resection for pancreatic ductal adenocarcinoma with curative intention is generally poor unless they have early-stage disease. Based on our 25-year experience, the results of 194 patients after a standardized Kausch-Whipple resection for adenocarcinoma of the pancreatic head were ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-002-6659-z
更新日期:2003-03-01 00:00:00
abstract::Because of the rarity of adrenocortical carcinoma, survival rates and the prognosis for patients who have undergone operation are not well known. The purpose of the French Association of Endocrine Surgery was to evaluate these factors over an 18-year period. A trend study was associated to assess changes in the clinic...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-001-0047-y
更新日期:2001-07-01 00:00:00
abstract::The previous finding of an increased risk of premature death in a consecutive series of 896 patients operated on for primary hyperparathyroidism between 1953 and 1982 [1] raised the question of the role that surgery plays in relation to the risk of death. In the present study, undertaken to examine that issue, 3 facto...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658740
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the feasibility of liver resection in hepatocellular carcinoma (HCC) patients with preoperative renal dysfunction (RD). METHODS:Data from 735 patients undergoing primary liver resection for HCC between 2002 and 2014 were analyzed. Short- and long-term outcomes were comp...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4698-3
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Frailty is a customized marker of biological age that helps to gauge an individual's functional physiologic reserve and ability to react to stress and is associated with increased postoperative morbidity and mortality. In order to mitigate frailty preoperatively, the concept of prehabilitation has entered th...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-020-05658-0
更新日期:2020-11-01 00:00:00
abstract::The moral dilemmas faced by surgeons worldwide who treat patients infected with the human immunodeficiency virus (HIV) can be viewed against the background of experience in sub-Saharan countries, where the community prevalence is in excess of 25% (90% of hospital inpatients). When seeking consent for an HIV test befor...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-7101-x
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:In patients with negative sentinel lymph node biopsy (SLNB), axillary dissection (AD) can be avoided to reduce morbidities. However, there is only limited data on the rate of positive non-SLN (NSLN) in those who have micrometastasis and isolated tumor cells (ITC) in the literature. METHODS:We did a retrospe...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-2984-x
更新日期:2015-06-01 00:00:00
abstract::Most people would agree that successful parathyroidectomy depends on two important variables: the surgeon's recognition and excision of the abnormal parathyroid gland(s) and the pathologist's confirmation that the removed tissue is parathyroid tissue. Frozen section is usually employed to confirm the identity of parat...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002680010218
更新日期:2000-11-01 00:00:00
abstract::Some 25%-70% of sporadic medullary thyroid carcinomas (MTCs) are associated with somatic mutations within the RET proto-oncogene. In a significant number of MTCs, however, no such genetic variations can be detected, which implies alternative pathogenic molecular alterations. To assess altered RET mutation-specific gen...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-004-7748-y
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Although laparoscopic appendectomy (LA) is widely performed in many countries, LA for complicated appendicitis, which includes perforated or gangrenous appendicitis with or without localized or disseminated peritonitis, has not become a common practice yet. METHODS:We retrospectively analyzed the clinical r...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9843-y
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Fast-track surgery (FTS) is a promising program for surgical patients and has been applied to several surgical diseases. FTS is much superior to conventional perioperative care. Our aim was to evaluate and compare the safety and efficacy of FTS and conventional perioperative care for patients undergoing gast...
journal_title:World journal of surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00268-014-2690-0
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Stenosis of esophago-jejuno anastomosis is one of the postoperative complications of gastric surgery. This complication usually manifests with the symptom of dysphagia and is treated by endoscopic dilatation. No large-scale studies have been conducted to determine the incidence of this complication after sur...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0609-y
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Enhanced recovery after surgery (ERAS(®)) pathways have reduced morbidity and length of hospital stay (LOS) in orthopedics, bariatric, and colorectal surgery. New perioperative care protocols have been tested in patients undergoing pancreaticoduodenectomy (PD), with controversial results on morbidity. Incomp...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2653-5
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Postoperative liver failure (PHLF) is one of the most common complications following major hepatectomy. The preoperative assessment of future liver remnant (FLR) function is critical to predict the incidence of PHLF. OBJECTIVE:To determine the efficacy of the plasma clearance rate of indocyanine green clear...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3441-1
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Laparoscopic proximal gastrectomy (LPG) is performed as a function-preserving surgery for patients with early proximal gastric malignant tumors; however, whether LPG has advantages postoperatively compared with laparoscopic total gastrectomy (LTG) is debatable, especially with regard to nutritional outcomes....
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4625-7
更新日期:2018-10-01 00:00:00
abstract::A total of 143 patients who underwent hepatic resection for hepatocellular carcinoma in our department were reviewed. The review was conducted for two periods: 1970-1982 (early period) and 1983-1990 (late period), that is, the periods before and after introduction of the hepatic surgical technique involving the use of...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01659138
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Unrecognized reduction of blood supply to intestinal organs is associated with significant postoperative morbidity in abdominal surgery. The aim of this study was to determine whether--in the absence of hypovolemia--intestinal hypoperfusion as a result of blood flow redistribution occurs after abdominal surg...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0560-y
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The impact of preoperative enteral nutrition (EN) on postoperative complications and recurrence in Crohn's disease (CD) has not been investigated to date. The purpose of the present study was to determine the effect of preoperative exclusive EN on postoperative complications and recurrence after bowel resect...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3488-z
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:It has been reported that the paraesophagogastric devascularization with esophageal transection procedure, also known as the modified Sugiura procedure, was effective in the treatment of variceal bleeding. However, it was not widely accepted by other surgeons because of the high rate of rebleeding, complicat...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2478-2
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Inflammation is integral to the pathogenesis of abdominal aortic aneurysm (AAA). This study examines preoperative biomarkers of systemic inflammation in patients undergoing open repair of intact and ruptured AAA. METHODS:One-hundred twelve patients were entered into a prospective observational study. Preope...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9014-6
更新日期:2007-06-01 00:00:00
abstract::Burn patients develop a number of physiologic alterations among which is a markedly increased metabolic rate. Other metabolic changes include an increased rate of glucose production and utilization, a decreased rate of lipid metabolism, and an increased rate of both protein catabolism and anabolism. These alterations ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF02067118
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The aim of this work was to study the impact of anemia on surgical outcomes and the impact of instituting appropriate workup and treatment of anemia on surgical outcomes. METHODS:We conducted a case-control retrospective chart review of all hernia repair, hydrocele repair, and hysterectomy cases at the SEAR...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1615-z
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Primary hyperparathyroidism (PHPT) is a common endocrine disorder that predominantly affects patients >60 and is increasing in prevalence. Identifying risk factors for poor outcomes after parathyroidectomy in older adults will help tailor operative decision making. The impact of frailty on surgical outcomes ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4629-3
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Barriers to female surgeons entering the field are well documented in Australia, the USA and the UK, but how generalizable these problems are to other regions remains unknown. METHODS:A cross-sectional survey was developed by the International Federation of Medical Students' Associations (IFMSA)'s Global Su...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05199-1
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the perioperative outcomes when using a micropuncture access set (MS) to those when using a conventional puncture set (CS) for implantation of totally implantable venous access device (TAVID). METHODS:A total of 314 patients undergoing chemotherapy for colorectal cancer ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05336-w
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Small bowel obstruction (SBO) is characterized by a high rate of recurrence. In the present study, we aimed to compare the outcomes of patients managed either by conservative treatment or surgical operation for an episode of SBO. METHODS:The outcomes of all patients hospitalized at a single center for acute...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2733-6
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to investigate the incidence of sleep disturbance and insomnia in patients with primary hyperparathyroidism (PHPT), and to evaluate the effect of parathyroidectomy. METHODS:A questionnaire was prospectively administered to adult patients with PHPT who underwent curative para...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s00268-013-2285-1
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:This is a baseline assessment of surgical capacity in the Federal Capital Territory (FCT), in preparation for the creation of a National Surgical, Obstetric, Anesthesia, and Nursing Plan. METHODS:In October 2017, all 10 of the 11 secondary hospitals in FCT that provide surgical and/or obstetric care were su...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4835-z
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Burns are a major public health concern, affecting mostly low- and middle-income countries. However, there is a lack of epidemiological studies on burns in these countries, particularly in Latin American countries. Our aim was to analyze nationwide demographic, epidemiological and economic characteristics of...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-3988-5
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:To evaluate whether the preoperative magnetic resonance angiography (MRA) can predict the risk of cerebral ischemia associated with the carotid endarterectomy (CEA). METHODS:Between January 2004 and December 2010, 382 consecutive patients (mean age: 56.6 years; range: 45-78 years) were identified to have un...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1851-2
更新日期:2013-03-01 00:00:00