Liver Resection for Hepatocellular Carcinoma in Patients with Renal Dysfunction.

Abstract:

BACKGROUND:The aim of this study was to evaluate the feasibility of liver resection in hepatocellular carcinoma (HCC) patients with preoperative renal dysfunction (RD). METHODS:Data from 735 patients undergoing primary liver resection for HCC between 2002 and 2014 were analyzed. Short- and long-term outcomes were compared between the RD group, defined by a preoperative estimated glomerular filtration rate of <45 mL/min/1.73 m2, and the non-RD group. RESULTS:Sixty-two patients had RD. The incidence of postoperative pleural effusion (24 vs. 11%; P = 0.007) and major complications (Clavien-Dindo III-V; 31 vs. 15%; P = 0.003) were significantly higher in RD patients. In RD patients with Child-Pugh A, 90-day mortality rate (1.9%) and median survival time (6.11 years) were comparable to that of non-RD patients. In contrast, RD patients with Child-Pugh B had a very high 90-day mortality rate (22.2%), and a significant shorter median survival time compared to non-RD patients (1.19 vs. 4.84 years; P = 0.001). CONCLUSIONS:Liver resection for Child-Pugh A patients with RD is safe and has comparable oncological outcomes compared to non-RD patients. However, selection of liver resection candidates from Child-Pugh B patients with RD should be stricter.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Shirata C,Hasegawa K,Kokudo T,Yamashita S,Yamamoto S,Arita J,Akamatsu N,Kaneko J,Sakamoto Y,Kokudo N

doi

10.1007/s00268-018-4698-3

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

4054-4062

issue

12

eissn

0364-2313

issn

1432-2323

pii

10.1007/s00268-018-4698-3

journal_volume

42

pub_type

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