Abstract：
:The G protein coupled receptors (GPCR) are an important class of proteins that act as signal transducers through the cytoplasmic membrane. Understanding the structure and activation mechanism of these proteins is crucial for understanding many different aspects of cellular signalling. The olfactory receptors correspond to the largest family of GPCRs. Very little is known about how the structures of the receptors govern the specificity of interaction which enables identification of particular odorant molecules. In this paper, we review recent developments in two areas of molecular modelling: methods for modelling the configuration of trans-membrane helices and methods for automatic docking of ligands into receptor structures. We then show how a subset of these methods can be combined to construct a model of a rat odorant receptor interacting with lyral for which experimental data are available. This modelling can help us make progress towards elucidating the specificity of interactions between receptors and odorant molecules.
journal_name
Biochimiejournal_title
Biochimieauthors
Afshar M,Hubbard RE,Demaille Jdoi
10.1016/s0300-9084(98)80019-9subject
Has Abstractpub_date
1998-02-01 00:00:00pages
129-35issue
2eissn
0300-9084issn
1638-6183pii
S0300-9084(98)80019-9journal_volume
80pub_type
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