Abstract：
:The field of immunometabolism has come a long way in the past decade, leading to the emergence of a new role for white adipose tissue (WAT) that is now recognized to stand at the junction of immune and metabolic regulations. Interestingly, a crucial role of the abundant and heterogeneous immune population present in WAT has been proposed in the induction and development of metabolic diseases. Although a large body of data focused on mature immune cells, only few scattered studies are dedicated to leukocyte production, and the activity of hematopoietic stem cells (HSC) in these pathological states. Considering that blood cell production and the differentiation of HSCs and their progeny is orchestrated, in part, by complex interacting signals emanating from their microenvironment, it thus seems worth to better understand the relationships between metabolism and HSC. This review discusses the alterations of hematopoietic process described in metabolic diseases and focused on the emerging data concerning HSC present in WAT.
journal_name
Biochimiejournal_title
Biochimieauthors
Cousin B,Casteilla L,Laharrague P,Luche E,Lorsignol A,Cuminetti V,Paupert Jdoi
10.1016/j.biochi.2015.06.012subject
Has Abstractpub_date
2016-05-01 00:00:00pages
21-26eissn
0300-9084issn
1638-6183pii
S0300-9084(15)00183-2journal_volume
124pub_type
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