Abstract：
:A higher level of N-acetylglucosamine incorporation by proteinic and polyprenic endogenous acceptors is observed after infection by Myxovirus. This phenomenon occurs in whole mitochondria as in outer mitochondrial membranes, where it is particularly obvious with proteinic endogenous acceptors. Under viral infection, no new N-acetylglucosaminylated polyprenol is detected. In the case of infected animals as in the case of control animals, compounds P1 (extracted by chloroform/methanol 2:1) are identified by thin layer chromatography as a N-acetylglucosamyl-pyrophosphoryl-dolichol and a N, N'-diacetylchitobiosyl-pyrophosphoryl-dolichol. In the case of infected animals, biosynthesis of proteinic acceptors and dolichol is not modified; therefore the increase of N-acetylglucosamine incorporation is not due to a modification of the endogenous acceptors level. By the use of exogenous dolichol-monophosphate we demonstrate that the increased transfer of [14C] N-acetylglucosamine into polyprenic acceptors is the result of a higher activity of the mitochondrial N-acetylglucosaminyltransferase after viral infection.
journal_name
Biochimiejournal_title
Biochimieauthors
Gateau O,Morelis R,Louisot Pdoi
10.1016/s0300-9084(80)80373-7subject
Has Abstractpub_date
1980-01-01 00:00:00pages
79-84issue
1eissn
0300-9084issn
1638-6183pii
S0300-9084(80)80373-7journal_volume
62pub_type
杂志文章相关文献
BIOCHIMIE文献大全abstract：:The biosynthesis of the beta-lactam antibiotic penicillin is an excellent model for the study of secondary metabolites produced by filamentous fungi due to the good background knowledge on the biochemistry and molecular genetics of the beta-lactam producing microorganisms. The three genes (pcbAB, pcbC, penDE) encoding...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2008.09.004
更新日期：2009-02-01 00:00:00
abstract：:Conformational changes induced by the binding of nickel to horseradish peroxidase C (HRPC) were studied by electronic absorption spectroscopy, fluorescence spectroscopy and circular dichroism spectroscopy. Incubation of HRPC with various concentrations of Ni(2+) for 5 minutes resulted in changes in the enzyme absorpti...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2006.04.001
更新日期：2006-09-01 00:00:00
abstract：:Diacylglycerol kinase (DGK) is a lipid-metabolizing enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKδ is highly expressed in the skeletal muscle, and a decrease in DGKδ expression increases the severity of type 2 diabetes. However, the role of DGKδ in myogenic differentiation is st...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2018.05.017
更新日期：2018-08-01 00:00:00
abstract：:In parallel with crystallographic studies of ribosomes from Thermus thermophilus, a long-term program on the crystallization and structural investigations of ribosomal proteins from the same microorganism has been started at the Institute of Protein Research (Pushchino, Russia). At present, more than half of the indiv...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(92)90110-z
更新日期：1992-04-01 00:00:00
abstract：:A number of specific Fab and Fv fragments and their complexes with antigens (avian lysozymes), haptens, and anti-idiotopic Fabs have been studied by immunochemical and crystallographic techniques. Antigen and antibody interact through closely complementary contacting surfaces, without major conformational changes. An ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(90)90114-v
更新日期：1990-08-01 00:00:00
abstract：:We have previously shown that withdrawal of folic acid led to metabolic reprogramming and a less aggressive phenotype in a mouse cell model of triple-negative breast cancer (TNBC). Herein, we evaluate the effects of folic acid withdrawal on transcriptomic profiles in these cells. Murine cell lines were originally deri...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2020.04.005
更新日期：2020-06-01 00:00:00
abstract：:In this study, peptidomics and genomics analyses were used to study antimicrobial peptides from the skin of Hylarana spinulosa. Twenty-nine different antimicrobial peptide precursors were characterized from the skin of H. spinulosa, which produce 23 mature antimicrobial peptides belonging to 12 different families. To ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2013.09.002
更新日期：2013-12-01 00:00:00
abstract：:Many natural phyto-products as perezone (Per) exhibit anti-cancer activities. Using experimental and computational studies, it was described that Poly ADP-ribose polymerase 1(PARP-1) inhibition and the induction of oxidative stress state explain the pro-apoptotic activity of Per. The aim of this study was to evaluate ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2020.03.003
更新日期：2020-01-01 00:00:00
abstract：:RNA phosphodiester bonds can be cleaved by metal ions, of which Pb2+ is one of the most effective. It can cleave both generally and site-specifically, depending on the substrate and the conditions. In addition, metal ions are also known to cleave ester bonds between amino acid and the 3'-end of transfer RNA. Here we r...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(94)90058-2
更新日期：1994-01-01 00:00:00
abstract：:In all living cells 3' ends of RNA are posttranscriptionally elongated or shortened by nucleotidyl transferases and ribonucleases. The detailed analysis of the rpsO mRNA of Escherichia coli presented here demonstrates that transcription terminates in vivo at two sites located seven and eight nucleotides downstream fro...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2005.02.012
更新日期：2005-09-01 00:00:00
abstract：:IbpA/B, 16 kDa heat-shock proteins were recently described as recognizing heterologous protein inclusion bodies in Escherichia coli cells; the corresponding genes formed an operon regulated by the rpoH gene product, sigma 32 protein (Burland et al (1993) Genomics 16, 551; Allen et al (1992) J Bacteriol 174, 6938; Chua...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(96)82643-5
更新日期：1996-01-01 00:00:00
abstract：:Cell walls of flocculent strains (0006) and non flocculent strains (0019) of Saccharomyces uvarum (Carlsbergensis), grown in different media and taken in both growth and stationary phases, were treated with water and with 2 per cent (W/V) potassium hydroxide. This treatment yielded four fractions (FI, FII, FIII and FR...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(81)80055-7
更新日期：1981-07-01 00:00:00
abstract：:We report Raman spectra of various cholinesterases: lytic tetrameric forms (G4) obtained by tryptic digestion of asymmetric acetylcholinesterase (AChE) from Torpedo californica and Electrophorus electricus, a PI-PLC-treated dimeric form (G2) of AChE from T marmorata, and the soluble tetrameric form (G4) of butyrylchol...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(91)90167-y
更新日期：1991-11-01 00:00:00
abstract：:Nephropathy is one of the most frequent complications of chronic diabetes. The main reason for nephropathy despite being hyperglycemia, but it progresses even after good glycemic control has been achieved in diabetic patients. The effects of prior exposure to high blood glucose conditions depend upon the severity and ...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2020.01.007
更新日期：2020-03-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that process growth factors, growth factor binding proteins, cell surface proteins, degrade extracellular matrix (ECM) components and thereby play a central role in tissue remodeling and tumor progression. Membrane-type matrix metalloproteinases (MT-...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2004.07.012
更新日期：2005-03-01 00:00:00
abstract：:Intracellular cytoplasmic peptidoglycan (PG) intermediate levels were determined in Staphylococcus aureus during log-phase growth in enriched media. Levels of UDP-linked intermediates were quantitatively determined using ion pairing LC-MS/MS in negative mode, and amine intermediates were quantitatively determined ster...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.11.017
更新日期：2016-02-01 00:00:00
abstract：:Diabetic cardiomyopathy is related to oxidative stress and correlated with the presence of advanced glycation end products (AGEs). In a clinical setting, AGEs can be detected in patients presenting diabetic cardiomyopathy; however, the underlying mechanism has yet to be elucidated. In our previous study, AGEs increase...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.07.019
更新日期：2015-11-01 00:00:00
abstract：:The iron absorption by duodenal enterocytes is a key step of its homeostasis. But the control of this absorption is complex and cannot be fully explicated with present knowledge. In a global transcriptome approach, we identified 60 genes over-expressed in hemin (iron) overload in Caco-2 cells, an in vitro model of duo...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2008.01.002
更新日期：2008-04-01 00:00:00
abstract：:The open reading frame PA3859 of Pseudomonas aeruginosa encodes an intracellular carboxylesterase belonging to a group of microbial enzymes (EC 3.1.1.1) that catalyze the hydrolysis of aliphatic and aromatic esters with a broad substrate specificity. With few exceptions, for this class of enzymes, belonging to the α/β...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2010.09.001
更新日期：2010-12-01 00:00:00
abstract：:Administration of beta-adrenergic agonists to domestic species can lead to skeletal muscle hypertrophy, probably by reducing the rate of myofibrillar protein breakdown. Myofibrillar breakdown is associated with the calcium-dependent proteinase system (calpains I,II and calpastatin) whose activity also changes during b...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(92)90125-x
更新日期：1992-03-01 00:00:00
abstract：:The presence of marker genes encoding antibiotic or herbicide resistances in genetically modified plants poses a number of problems. Various techniques are under development for the removal of unwanted marker genes, while leaving required transgenes in place. The aim of this brief review is to describe the principal m...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/s0300-9084(02)00021-4
更新日期：2002-11-01 00:00:00
abstract：:The elucidation of the multiple signaling cascades coupled to the TSH receptor has offered new approaches in the understanding of the pathogenesis of Graves' disease. Here we review findings showing that immunoglobulins from Graves' patients are heterogeneous, bind to different epitopes and, similarly to TSH, activate...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/s0300-9084(99)80090-x
更新日期：1999-05-01 00:00:00
abstract：:Honeybee-plant relationships are based on a conditioning process in which olfactory (plant aroma) and gustatory cues (mainly nectars) are closely linked, leading to a selective foraging behaviour. Among crops dependent upon entomophilous cross-pollination, the sunflower has recently undergone extensive expansion due t...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(87)90186-6
更新日期：1987-06-01 00:00:00
abstract：:The function of glycerophosphate and malate-aspartate shuttles during glucose metabolism in two strains of Ehrlich ascites tumor cells was evaluated by several experimental approaches. The activities of the enzymes involved in these shuttle systems were assayed in the cytosolic and mitochondrial compartments after cel...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(85)80055-9
更新日期：1985-02-01 00:00:00
abstract：:Certain transcription factors have recently been shown to interact with DNA in living cells, through very short binding cycles, contrasting with the data previously obtained in vitro, and with the view of a stepwise building of transcription initiation complexes. These short cycles are triggered by active dissociation...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2009.03.022
更新日期：2009-07-01 00:00:00
abstract：:Pleurocidin (GWGSFFKKAAHVGKHVGKAALTHYL-NH(2)), found in skin mucous secretions of the winter flounder Pleuronectes americanus, is known to possess a high potency and broad-spectrum antimicrobial peptide without cytotoxicity. In this study, to investigate the impact of pleurocidin on apoptotic progress, we observed mor...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2011.07.011
更新日期：2011-10-01 00:00:00
abstract：:Peptidase family S46 consists of two types of dipeptidyl-peptidases (DPPs), DPP7 and DPP11, which liberate dipeptides from the N-termini of polypeptides along with the penultimate hydrophobic and acidic residues, respectively. Their specificities are primarily defined by a single amino acid residue, Gly673 in DPP7 and...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2017.10.015
更新日期：2018-04-01 00:00:00
abstract：:Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown adipose tissues. The accumulating evidence confirms the presence of active brown adipocytes, not onl...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2017.04.017
更新日期：2017-07-01 00:00:00
abstract：:In recent years the chaperone HSC-70 has become a target for drug design with a strong focus in anticancer therapies. In our study of possible inhibitors of HSC-70 enzymatic activity we screened compounds by NMR as well as X-ray crystallography. As part of our screening efforts we crystallized the human HSC-70 ATP bin...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.11.012
更新日期：2015-01-01 00:00:00
abstract：:Although a 30 kDa polypeptide frequently is seen by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of post mortem (pm) skeletal muscle and in turn is used as an indicator of proteolysis, its origin has not been conclusively identified. We used antibodies to selected myofibrillar proteins...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(94)90110-4
更新日期：1994-01-01 00:00:00
