Abstract：
:The elucidation of the multiple signaling cascades coupled to the TSH receptor has offered new approaches in the understanding of the pathogenesis of Graves' disease. Here we review findings showing that immunoglobulins from Graves' patients are heterogeneous, bind to different epitopes and, similarly to TSH, activate different signaling pathways, including adenylyl cyclase, phospholipase C and phospholipase A2. Evidence that the multiplicity of signals correlates with the different manifestations of the disease is also summarized. We believe that the dissection of the molecular mechanisms involved in the pathogenesis of Graves' disease offers the basis for developing novel therapeutical approaches to this disease.
journal_name
Biochimiejournal_title
Biochimieauthors
Di Cerbo A,Corda Ddoi
10.1016/s0300-9084(99)80090-xkeywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
415-24issue
5eissn
0300-9084issn
1638-6183pii
S0300-9084(99)80090-Xjournal_volume
81pub_type
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