Abstract：
:Apoptosis is the physiological process by which unwanted cells in an organism are killed. Bcl-2, a membrane-bound cytoplasmic protein, and its close relative Bcl-xL, are both effective inhibitors of apoptosis induced by a wide variety of stimuli in many different cell types. In a previous study, we reported that suppression of apoptosis by Bcl-2 or Bcl-xL, markedly elevates the levels of radiation-induced mutations at the specific locus thymidine kinase. We investigated the effect of the Bcl-2 or Bcl-xL overproduction on hydrogen peroxide-induced mutagenesis. Oxidative DNA damage has been implicated in biological processes such as mutagenesis, carcinogenesis and aging. Overexpression of either Bcl-2 or Bcl-xL enhances oxidative stress mutagenesis in cells with wild type p53 as well as with mutated p53 protein. These results support the hypothesis that apoptosis plays a crucial role in maintaining genomic integrity by selectively eliminating highly mutated cells from the population.
journal_name
Biochimiejournal_title
Biochimieauthors
Cherbonnel-Lasserre C,Dosanjh MKdoi
10.1016/s0300-9084(97)82011-1subject
Has Abstractpub_date
1997-10-01 00:00:00pages
613-7issue
9-10eissn
0300-9084issn
1638-6183pii
S0300-9084(97)82011-1journal_volume
79pub_type
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