Abstract:
:Conjugated linoleic acids (CLA) are positional and geometric dienoic isomers of linoleic acid. Dietary CLA supplementation leads to a drop in fat mass in various species, including in humans. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with severe hyperinsulinemia, insulin resistance and massive liver steatosis. The origin of these adverse side effects and putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.
journal_name
Biochimiejournal_title
Biochimieauthors
Poirier H,Niot I,Clément L,Guerre-Millo M,Besnard Pdoi
10.1016/j.biochi.2004.11.006keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
73-9issue
1eissn
0300-9084issn
1638-6183pii
S0300-9084(04)00232-9journal_volume
87pub_type
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