Abstract：
:Classic studies suggested that the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) is an oncofetal antigen in humans, being immunogenic in adult humans and yet apparently expressed in human fetuses and tumors. We and others have recently found that the human deficiency of Neu5Gc can be explained by an inactivating mutation in the gene encoding CMP-N-acetylneuraminic acid hydroxylase. Thus, Neu5Gc is not an oncofetal antigen in the classical sense, and other explanations must be found for the observed expression pattern. This review provides an update on this matter, and considers a variety of other old and new questions that arise from it.
journal_name
Biochimiejournal_title
Biochimieauthors
Varki Adoi
10.1016/s0300-9084(01)01309-8keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
615-22issue
7eissn
0300-9084issn
1638-6183pii
S0300-9084(01)01309-8journal_volume
83pub_type
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