The assembly of prokaryotic ribosomes.

abstract：:The quantitative formalism called Metabolic Control Theory makes it possible to be precise in discussions of metabolic control. To illustrate this, I will mention 2 experimental systems where free energy is converted from one form to another, i.e., bacteriorhodopsin liposomes and mitochondrial oxidative phosphorylatio...

journal_title：Biochimie

authors： Westerhoff HV

更新日期：1989-08-01 00:00:00

abstract：:In order to study the role of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK-C) in skeletal muscle, PEPCK-Cmus mice were created by introducing the cDNA for the enzyme, linked to the human alpha-skeletal actin gene promoter, into their germ line. Two founder lines generated by this ...

journal_title：Biochimie

authors： Hanson RW,Hakimi P

更新日期：2008-06-01 00:00:00

abstract：:The multisubunit Mediator is an evolutionary conserved transcriptional coregulatory complex in eukaryotes. It is needed for the transcriptional regulation of gene expression in general as well as in a gene specific manner. Mediator complex subunits interact with different transcription factors as well as components of...

journal_title：Biochimie

authors： Ranjan A,Ansari SA

更新日期：2018-01-01 00:00:00

abstract：:Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown adipose tissues. The accumulating evidence confirms the presence of active brown adipocytes, not onl...

journal_title：Biochimie

authors： Chu DT,Gawronska-Kozak B

更新日期：2017-07-01 00:00:00

abstract：:Conjugated linoleic acids (CLA) are positional and geometric dienoic isomers of linoleic acid. Dietary CLA supplementation leads to a drop in fat mass in various species, including in humans. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mou...

journal_title：Biochimie

authors： Poirier H,Niot I,Clément L,Guerre-Millo M,Besnard P

更新日期：2005-01-01 00:00:00

abstract：:The crystallographic structure of a novel trypsin inhibitor (CTI) from Copaifera langsdorffii is reported. The structure was solved by MIRAS procedure and refined to a crystallographic residual of 17.3% (R(free) = 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by quick cryo-soaking approach. CTI...

journal_title：Biochimie

authors： Krauchenco S,Nagem RA,da Silva JA,Marangoni S,Polikarpov I

更新日期：2004-03-01 00:00:00

abstract：:Long-term treatment with ambroxol (ABX), a bronchial expectorant, was found to prevent acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The underlying mechanism remains unclear. To address this, we have investigated the effect of ABX on critical antioxidant proteins thioredoxin (Trx) and thioredox...

journal_title：Biochimie

authors： Huang J,Xu J,Tian L,Zhong L

更新日期：2014-02-01 00:00:00

abstract：:Our previous researches showed that nitronyl nitroxyl derivatives, NNP and NNVP were good anti-oxidants and provided radioprotective effects in C6 cells. The objective of the present study is to investigate the possible antiviral effects and underlying pharmacological of the two nitronyl nitroxide radicals against CVB...

journal_title：Biochimie

authors： Wang H,Gao P,Jing L,Qin X,Sun X

更新日期：2012-09-01 00:00:00

abstract：:Human α(1)-acid glycoprotein (AGP) is a positive acute phase plasma protein containing two disulfide bridges. Structural studies have shown that under specific conditions AGP undergoes aggregation. In this study, we analysed the nature of AGP's aggregates formed under reducing and non-reducing conditions at pH 5.5 and...

journal_title：Biochimie

authors： Scirè A,Baldassarre M,Galeazzi R,Tanfani F

更新日期：2013-02-01 00:00:00

abstract：:The distribution of fatty acids among cellular glycerophospholipids is finely regulated by the CoA-dependent acylation of lysophospholipids followed by transacylation reactions. Arachidonic acid is the fatty acid precursor of a wide family of bioactive compounds called the eicosanoids, with key roles in innate immunit...

journal_title：Biochimie

authors： Balgoma D,Montero O,Balboa MA,Balsinde J

更新日期：2010-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that process growth factors, growth factor binding proteins, cell surface proteins, degrade extracellular matrix (ECM) components and thereby play a central role in tissue remodeling and tumor progression. Membrane-type matrix metalloproteinases (MT-...

journal_title：Biochimie

authors： Sounni NE,Noel A

更新日期：2005-03-01 00:00:00

abstract：:Bacterial survive and respond to adverse changes in the environment by regulating gene transcription through two-component regulatory systems. In Salmonella Typhimurium the STM1485 gene expression is induced under low pH (4.5) during replication inside the epithelial host cell, but it is not involved in sensing or res...

journal_title：Biochimie

authors： Torrez Lamberti MF,Farizano JV,López FE,Martínez Zamora MG,Pescaretti MM,Delgado MA

更新日期：2019-05-01 00:00:00

abstract：:Multiple forms of acetylcholinesterase have been studied in Goldfish adapted to 15 degrees C and 25 degrees C. Three forms of enzyme (sedimenting at 18S, 12S and 5S) could be distinguished by sucrose gradient centrifugation. Their molecular and enzymatic properties did not vary with environmental temperature. It was n...

journal_title：Biochimie

authors： Guillon G,Massoulié J,Guillon G,Massoulié J

更新日期：1976-01-01 00:00:00

abstract：:In the intestine, NF-κB is the main transcription factor involved in the anti-inflammatory effect of glutamine and we previously demonstrated that glutamine via its conversion to glutamate diminished the p65 protein content in Caco-2/TC7 cell nuclei without affecting the stimulating effect of IL-1β on NF-κB [21]. Howe...

journal_title：Biochimie

authors： Lesueur C,Bôle-Feysot C,Bekri S,Husson A,Lavoinne A,Brasse-Lagnel C

更新日期：2012-03-01 00:00:00

abstract：:Obesity prevalence continues to rise throughout the developed world, as a result of positive energy balance and reduced physical activity. At present, there is still a perception within the general community, and amongst some nutritionists, that eating multiple small meals spaced throughout the day is beneficial for w...

journal_title：Biochimie

authors： Hutchison AT,Heilbronn LK

更新日期：2016-05-01 00:00:00

abstract：:The ability to measure the thermodynamic stability of proteins with precision is important for both academic and applied research. Such measurements rely on mathematical models of the protein denaturation profile, i.e. the relation between a global protein signal, corresponding to the folding states in equilibrium, an...

journal_title：Biochimie

authors： Bedouelle H

更新日期：2016-02-01 00:00:00

abstract：:Three different hydrogenases (isolated from Clostridium pasteurianum, Desulfovibrio desulfuricans strain Norway 4 and D. baculatus 9974) added to a suspension of TiO2 (anatase) powder are able to catalyze H2 evolution under band gap illumination of the semiconducting particles, and in the presence of EDTA or methanol ...

journal_title：Biochimie

authors： Cuendet P,Rao KK,Grätzel M,Hall DO

更新日期：1986-01-01 00:00:00

abstract：:The rat and rabbit lung isoform pattern before (fetal) and after (adult) lung maturation has been analyzed by isoelectric focusing. This pattern has been compared to that of brain tubulin at the same developmental stages. No changes in the pattern of fetal and adult lung tubulin were found. However an increase in brai...

journal_title：Biochimie

authors： Déiz JC,Avila J

更新日期：1985-09-01 00:00:00

abstract：:In vitro cycling rates of E. coli ribosomes and of elongation factors EF-Tu and EF-G have been obtained and these are compatible with translation rates in vivo. We show that the rate of translocation is faster than 50 s-1 and therefore that the EF-G function is not a rate limiting step in protein synthesis. The in viv...

journal_title：Biochimie

authors： Bilgin N,Kirsebom LA,Ehrenberg M,Kurland CG

更新日期：1988-05-01 00:00:00

abstract：:Chronic hypobaric hypoxia induced muscle atrophy results in decreased physical performance at high altitude. Curcumin has been shown to have muscle sparing effects under cachectic conditions. However, the protective effects of curcumin under chronic hypobaric hypoxia have not been studied till now. Therefore, the pres...

journal_title：Biochimie

authors： Chaudhary P,Sharma YK,Sharma S,Singh SN,Suryakumar G

更新日期：2019-01-01 00:00:00

abstract：:Human Rad51 (HsRad51), a key element of the homologous recombination repair pathway, is related to the resistance of cancer cells to chemo- and radio-therapies. This protein is thus a good target for the development of anti-cancer treatments. We have searched for new inhibitors directed against HsRad51 using the Syste...

journal_title：Biochimie

authors： Martinez SF,Renodon-Cornière A,Nomme J,Eveillard D,Fleury F,Takahashi M,Weigel P

更新日期：2010-12-01 00:00:00

abstract：:We have studied the kinetics of erythromycin inhibition of translation in growing bacteria. In order to simplify the interpretation of our data, we have used a mutant (envA), known to have an increased permeability to several antibiotics, including erythromycin. The data clearly show that an initial stage of translati...

journal_title：Biochimie

authors： Andersson S,Kurland CG

更新日期：1987-08-01 00:00:00

abstract：:We have analysed the complete sequence of the Escherichia coli K12 isolate MG1655 genome for chromatin-associated protein binding sites, and compared the predicted location of predicted sites with experimental expression data from 'DNA chip' experiments. Of the dozen proteins associated with chromatin in E. coli, only...

journal_title：Biochimie

authors： Ussery D,Larsen TS,Wilkes KT,Friis C,Worning P,Krogh A,Brunak S

更新日期：2001-02-01 00:00:00

abstract：:The termination of protein synthesis in bacteria requires codon-specific polypeptide release factors RF-1 (UAG/UAA specific) and RF-2 (UGA/UAA specific). We have proposed that release factors mimic tRNA and recognize the stop codon for polypeptide release (Nakamura et al (1996) Cell 87, 147-150). In contrast to the te...

journal_title：Biochimie

authors： Uno M,Ito K,Nakamura Y

更新日期：1996-01-01 00:00:00

abstract：:A high level of subcellular compartmentalization is a hallmark of eukaryotic cells. This intricate internal organization was present already in the common ancestor of all extant eukaryotes, and the determination of the origins and early evolution of the different organelles remains largely elusive. Organellar proteome...

journal_title：Biochimie

authors： Gabaldón T,Pittis AA

更新日期：2015-12-01 00:00:00

abstract：:Polynucleotide phosphorylase (PNPase, polyribonucleotide nucleotidyltransferase, EC 2.7.7.8) is a multifunctional protein, with a 3'-5' processive exoribonuclease, a Pi exchange, an RNA polymerase and an autoregulatory activity. The interaction between this enzyme and the mRNA target is crucial for its activities. In ...

journal_title：Biochimie

authors： Bermúdez-Cruz RM,García-Mena J,Montañez C

更新日期：2002-04-01 00:00:00

abstract：:The possibility that brown adipose tissue thermogenesis can be recruited in order to combat the development of obesity has led to a high interest in the identification of "browning agents", i.e. agents that increase the amount and activity of UCP1 in brown and brite/beige adipose tissues. However, functional analysis ...

journal_title：Biochimie

authors： Kalinovich AV,de Jong JM,Cannon B,Nedergaard J

更新日期：2017-03-01 00:00:00

abstract：:The single channel data for 4 different linear gramicidins containing either 4 Trp, 4 Phe, 4 Tyr or TyrBzl have been analyzed on the basis of 3 barriers-2 sites model. They form 2 families which differ by their single channel behavior and thus different energy profiles of the channel. A relationship between the surfac...

journal_title：Biochimie

authors： Heitz F,Van Mau N,Bennes R,Daumas P,Trudelle Y

更新日期：1989-01-01 00:00:00

abstract：:Two methods were used to estimate the intracellular phospholipase activity in rat heart: one using exogenous radioactive substrate dispersed as unilamellar vesicles; the other using endogenous membrane hydrolysis and subsequent phospholipid and lysophospholipid separation by high-performance liquid chromatography and ...

journal_title：Biochimie

authors： Termine E,Léonardi J,Lafont H,Nalbone G

更新日期：1987-03-01 00:00:00

abstract：:Crystals of flavoenzyme L-lactate oxidase from Aerococcus viridans (LOX) have been obtained that diffract to 3.0 A resolution (P2(1)2(1)2(1), a = 118.4 A, b = 138.4 A, c = 194.6 A). Crystallographic studies suggest that the enzyme may exist as an octameric form with non-crystallographic two- and four-fold axes in the ...

journal_title：Biochimie

authors： Morimoto Y,Yorita K,Aki K,Misaki H,Massey V

更新日期：1998-04-01 00:00:00