Abstract:
:In vivo transfection by intramuscular injection with plasmids expressing the immunogenic proteins of microbial pathogens has considerable potential as a vaccination strategy against many pathogens of both man and animals. Here we report that weanling mice given a single intramuscular injection of 50 micrograms of a plasmid, pSLE1 expressing the St. Louis encephalitis virus (SLE) prM/E protein under the control of the cytomegalovirus immediate early protein promoter produced SLE-specific antibody and were protected against lethal challenge with the virulent virus. Polynucleotide vaccine technology provides a unique opportunity to produce vaccines against flavivirus diseases of low incidence cheaply and rapidly, and to produce multivalent vaccines such as would be required for immunisation against dengue virus disease.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Phillpotts RJ,Venugopal K,Brooks Tdoi
10.1007/BF01718332subject
Has Abstractpub_date
1996-01-01 00:00:00pages
743-9issue
3-4eissn
0304-8608issn
1432-8798journal_volume
141pub_type
杂志文章abstract::This study was done to understand the dynamics of rotavirus genotype distribution in Turkish children. Samples were collected from January 2006 through August 2011 from children at a hospital in Ankara. Rotavirus was detected in 28 % (241/889) of the samples. Genotype G9P[8] was predominant (28 %), followed by G1P[8] ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-016-2986-5
更新日期:2016-10-01 00:00:00
abstract::Six synthetic peptides corresponding to regions of bovine enterovirus (BEV), strain VG-5-27, elicited antibodies in mice which reacted with the virus in various assays. These antibodies have been characterised on the basis of their ability to (1) neutralize the virus, (2) bind to the intact virus particle in an immuno...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01309681
更新日期:1992-01-01 00:00:00
abstract::Emilia sonchifolia is a traditionally used medicinal plant that is widespread in tropical and subtropical regions of the world. Yellow vein symptoms were observed in E. sonchifolia plants in fields in the county of Koh Samui, Surat Thani Province, Thailand, in August 2015. Two distinct begomoviruses, designated TH4872...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-3762-5
更新日期:2018-06-01 00:00:00
abstract::A potyvirus isolated from Pinellia ternata in China was characterised and shown to be related to Soybean mosaic virus (SMV). The virus was pathogenic on P. ternata and some soybean cultivars, whereas the local soybean SMV isolate HH5 did not infect P. ternata. Western blot experiments demonstrated a serological relati...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-003-0184-8
更新日期:2004-02-01 00:00:00
abstract::NDV variants released from the early passaged BHK21/WI-2 cells persistently infected with NDV carry the structural antigen of a latent virus of BHK21/WI-2 cells as a result of phenotypic mixing between NDV and the latent virus. ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01317290
更新日期:1978-01-01 00:00:00
abstract::Four distinct double-stranded (ds) RNA bands were extracted from leaves of Raphanus sativus-root cv. Yidianhong [corrected] with yellowing at the leaf edge in China. Purified viral particles of 28-30 nm in diameter contained dsRNA segments with the same number and mobility as these extracted directly from radish leave...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-005-0685-8
更新日期:2006-05-01 00:00:00
abstract::Virus-like particles (VLP), morphologically similar to togavirus particles, were detected in the sera of chimpanzees and humans with chronic non-A, non-B (NANB) hepatitis. Particles resembling the virus were also found in the cytoplasm of hepatocytes obtained from NANB hepatitis infected chimpanzees. Furthermore, two ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01315557
更新日期:1989-01-01 00:00:00
abstract::Reticuloendotheliosis virus (REV) is an important representative avian retrovirus. To improve our understanding of the host cellular responses to virus infection and the pathogenesis of REV infection, we applied isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled with multidimensional liqui...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-019-04409-4
更新日期:2019-12-01 00:00:00
abstract::Astroviruses are associated with acute gastroenteritis of human and many animal species. Recently, two studies have reported that novel astroviruses were found in bats. In order to extensively understand the genetic and phylogenetic characterization of bat astroviruses, we tested fecal samples of nine bat species that...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-011-1011-2
更新日期:2011-08-01 00:00:00
abstract::Drosophila C virus RNA acted as mRNA in rabbit reticulocyte lysates and directed the synthesis of at least one capsid protein and a number of higher molecular weight proteins. Kinetic analysis by pulse-chase experiments showed that a number of high molecular weight products acted as precursors to the capsid protein(s)...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01311694
更新日期:1983-01-01 00:00:00
abstract::Rice transitory yellowing virus (RTYV), a member of the genus Nucleorhabdovirus, is closely related to or synonymous with rice yellow stunt virus (RYSV). To clarify the relationship between RTYV and RYSV, we determined the nucleotide sequence of the RTYV genome. The RTYV genome consists of 14,029 nucleotides. The over...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-009-0557-8
更新日期:2010-02-01 00:00:00
abstract::The complete nucleotide sequence of the RNA genome of turnip mosaic virus Japanese strain (TuMV-J) has been determined from five overlapping cDNA clones and by direct sequencing of viral RNA. The RNA sequence was 9833 nucleotides in length, excluding a 3' terminal poly(A) tail. An AUG triplet at position 130-132 was a...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01718209
更新日期:1996-01-01 00:00:00
abstract::Six novel subgenotypes (B7, B8, C6, C8, C9, and D6) within three hepatitis B virus (HBV) genotypes (B-D) were recently identified in Indonesia. To further characterize HBV in this country, 18 HBV-viremic samples obtained from blood donors in Nusa Tenggara, Indonesia, were subjected to phylogenetic analysis of an 1.6-k...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-010-0628-x
更新日期:2010-05-01 00:00:00
abstract::Enzootic bovine leukosis (EBL) is a malignant B-cell lymphoma of cattle caused by infection with bovine leukemia virus (BLV). It is defined by clonal and neoplastic expansion of BLV-infected B cells. Currently, multiple examinations are able to comprehensively diagnose this condition. Inverse polymerase chain reaction...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-020-04945-4
更新日期:2021-01-24 00:00:00
abstract::Mycobacteriophage archival stocks have been kept for ca. 20-50 years in Japan. In this study, we attempted to recover mycobacteriophages from 50 archival stocks and briefly analyzed the recovered phages. The phages were recovered from 72.2% (13/18) of the lyophilized stocks that had been stored for 47-56 years. Moreov...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-3788-8
更新日期:2018-07-01 00:00:00
abstract::The C-terminal R peptide of ecotropic murine leukemia virus (MLV) envelope protein (Env) negatively controls membrane fusion activity. The R peptide cleavage during virion maturation activates its fusogenicity and is required for viral entry. We analyzed fusogenicity and transduction efficiency of mutant Env proteins ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-007-1054-6
更新日期:2007-01-01 00:00:00
abstract::The viral erythrocytic infection (VEI) of sea bass (Dicentrarchus labrax) is evidenced by the presence of inclusion bodies in the erythrocytes and erythroblasts. Virus-like particles (VEIV) about 135-150 nm in diameter were observed in erythroblasts of affected fish. No culturable virus could be recovered from the org...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310951
更新日期:1991-01-01 00:00:00
abstract::Rabies virus (RABV) isolates from two species of canids and three species of bats were analyzed by comparing the C-terminal region of the G gene and the G-L intergenic region of the virus genome. Intercluster identities for the genetic sequences of the isolates showed both regions to be poorly conserved. Phylogenetic ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-010-0671-7
更新日期:2010-06-01 00:00:00
abstract::Ninety four percent of the genome of bovine herpesvirus 4 (BHV-4) strain DN 599 was cloned and a physical map was constructed by Southern blot analysis using a library of cloned fragments cleaved with the 3 restriction enzymes (Eco RI, Bam HI, and Hin dIII). The genome length was estimated to be 156.5 kbp +/- 0.7. The...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01309576
更新日期:1992-01-01 00:00:00
abstract::The complete genome sequence of a Chinese very virulent infectious bursal disease virus (vvIBDV) strain, Harbin-1, was determined. Based on the sequence analysis, the molecular characteristics and potential virulence determinants and origin of vvIBDV strains were identified. Phylogenetic analysis indicated that a reas...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-008-0140-8
更新日期:2008-01-01 00:00:00
abstract::Strawberry crinkle disease is one of the major diseases that threatens strawberry production. Although the biological properties of the agent, strawberry crinkle virus (SCV), have been thoroughly investigated, its complete genome sequence has never been published. Existing RT-PCR-based detection relies on a partial se...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-3860-4
更新日期:2018-09-01 00:00:00
abstract::Synthesis of murine gamma interferon (MuIFN gamma) by phytohemagglutinin (PHA)-stimulated spleen cells was inhibited in a dose-dependent manner by graded concentrations of tunicamycin or 2-deoxy-glucose, both of which inhibit glycosylation. The homologous (murine) and heterologous (rat) antiviral activities of the MuI...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310659
更新日期:1984-01-01 00:00:00
abstract::We investigated the in situ localization of the 50 kDa protein encoded by ORF2 of Apple chlorotic leaf spot virus (ACLSV) genome which is thought to be a movement protein. In immunogold electron microscopy of ACLSV-infected Chenopodium quinoa leaves, the 50 kDa protein was localized on plasmodesmata and nearby cytopla...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050660
更新日期:1999-01-01 00:00:00
abstract::Algeria is the largest country of Africa, with a population of 40 million inhabitants living in disparate environments from the Sahara to the large cities of the Mediterranean coast. The molecular epidemiology of hepatitis B virus (HBV) variants has been partially described, but variations in the seroprevalence of HBV...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-017-3284-6
更新日期:2017-06-01 00:00:00
abstract::Simian adenovirus SA7 heated for 30 minutes at 70 degrees C retained part of its ability to induce tumors in newborn hamsters. Tumors were also induced by DNA extracted from the heated virus. However, neither residual replicating, i.e. cytopathogenic, nor transforming and T-antigen-inducing activities could be detecte...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01317334
更新日期:1981-01-01 00:00:00
abstract::A replication-defective, recombinant Sindbis virus vector was utilized in a novel immunization strategy to induce humoral and cellular responses against hepatitis C virus (HCV). The recombinant vector, pVaXJ-E1E2, expressing the gene for HCV glycoproteins E2 and E1, was constructed by inserting the E1E2 gene into the ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1564-8
更新日期:2013-05-01 00:00:00
abstract::An archival brain sample from an infected dog taken during the 1988/89 rabies outbreak in Finland was investigated to confirm that it was infected with classical rabies virus (genotype 1). The first 400 base pairs of the virus nucleoprotein gene were then sequenced and used to undertake a phylogenetic comparison betwe...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-005-0523-z
更新日期:2005-07-01 00:00:00
abstract::We have sequenced the complete genome of an isolate of Banana streak virus from banana cv. 'Mysore' and show that it is sufficiently different from a previously characterised isolate from cv. 'Obino l'Ewai' to warrant recognition as a distinct species, for which the name Banana streak Mysore virus (BSMysV) is proposed...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-004-0471-z
更新日期:2005-04-01 00:00:00
abstract::Retrovirus-like particles were isolated from the urine of a patient with psoriasis. The major internal protein, p27, in these particles was isolated by immunosorbent chromatography and gel filtration on a Sephacryl S-300 column in 6 M guanidine hydrochloride. The protein was purified to homogeneity as judged by SDS-PA...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01314231
更新日期:1985-01-01 00:00:00
abstract::The acid-extractable leaf proteins of potato spindle tuber viroid (PSTV) infected tomato plants were analysed electrophoretically on polyacrylamide gels. The most prominent alteration found during disease development was the appearance of a "pathogenesis-related" protein with an apparent molecular weight of 14,000 (ca...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01309998
更新日期:1984-01-01 00:00:00