Abstract：
:The C-terminal R peptide of ecotropic murine leukemia virus (MLV) envelope protein (Env) negatively controls membrane fusion activity. The R peptide cleavage during virion maturation activates its fusogenicity and is required for viral entry. We analyzed fusogenicity and transduction efficiency of mutant Env proteins of ecotropic, amphotropic, polytropic, and xenotropic MLVs. As the result, we found that the hydrophobic amino acid residues around the R peptide cleavage site are important for membrane fusion inhibition by the R peptide. In addition, we found that Env complexes with R peptide-truncated and -containing Env proteins have lower fusogenicity and transduction efficiency than those with the R-peptide-truncated Env alone, suggesting that efficient R peptide cleavage is required for efficient MLV vector transduction. The role of R peptide cleavage in amphotropic, polytropic, and xenotropic MLV infection has not been investigated. We found in this study that the R peptide cleavage is required for amphotropic, xenotropic, and polytropic MLV vector transduction, like with ecotropic MLV. The R-peptide-truncated Env proteins of the xenotropic and polytropic MLVs, however, had much lower fusogenicity than those of the ecotropic and amphotropic MLVs. These results provide valuable information for construction of efficient MLV vectors and for understanding the retroviral entry mechanism.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Kubo Y,Tominaga C,Yoshii H,Kamiyama H,Mitani C,Amanuma H,Yamamoto Ndoi
10.1007/s00705-007-1054-6subject
Has Abstractpub_date
2007-01-01 00:00:00pages
2169-82issue
12eissn
0304-8608issn
1432-8798journal_volume
152pub_type
杂志文章abstract：:Despite reports that the PB1-F2 protein contributes to influenza virus pathogenicity in the mouse model, little is known about its significance in avian hosts. In our previous study, the A/Vietnam/1203/04 (H5N1) wild-type virus (wtVN1203) was more lethal to mallard ducks than a reverse genetics (rg)-derived VN1203. In...
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s00705-007-0945-x
更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00705-002-0788-4
更新日期：2002-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00705-018-4089-y
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-3212-1
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journal_title：Archives of virology
pub_type： 杂志文章
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314606
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doi：10.1007/s00705-017-3260-1
更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-12-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01320788
更新日期：1981-01-01 00:00:00
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doi：10.1007/s00705-008-0152-4
更新日期：2008-01-01 00:00:00
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doi：10.1007/s00705-016-2760-8
更新日期：2016-05-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050561
更新日期：1999-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318024
更新日期：1976-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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更新日期：2016-09-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050170199
更新日期：2001-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050191
更新日期：1997-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314121
更新日期：1985-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
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更新日期：2010-11-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315007
更新日期：1981-01-01 00:00:00
abstract：:Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International Committee on Taxonomy of Viruses (ICTV) Polyomaviridae Study Group designed a host- and sequenc...
journal_title：Archives of virology
pub_type： 新闻
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更新日期：2016-06-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0190-x
更新日期：2004-01-01 00:00:00
