Ocular findings in a patient with Prader-Willi syndrome.

abstract：:Glycine is an important inhibitory neurotransmitter in the vertebrate retina. Although many reports of glycine localization by the immunocytochemical method have been published, none has distinguished the neurotransmitter function of glycine from metabolic change. If glycine is the neurotransmitter, it seems that it m...

journal_title：Japanese journal of ophthalmology

authors： Nishikawa S,Ishiguro S,Tamai M

更新日期：1996-01-01 00:00:00

abstract：:Prostaglandin D2 (PGD2) and 64E, a derivative of PGs, were tested for their capacity to suppress the growth of retinoblastoma in the nude mouse. Ten million cells of an established cell line of human retinoblastoma, Y-79 cells, were transferred subcutaneously into the nude mouse, and after the transferred cells became...

journal_title：Japanese journal of ophthalmology

authors： Nakamura M,Fujino Y,Mochizuki M,Minoda K,Masuda K

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To determine whether P7C3-A20, a proneurogenic neuroprotective agent, can protect the retinal ganglion cells (RGCs) of rats from optic nerve crushing. METHODS:The left optic nerve of 67 rats was crushed, and 5.0 mg/kg/day of P7C3-A20 (crush-P7C3) or its vehicle (crush-placebo) was injected intraperitoneally fo...

journal_title：Japanese journal of ophthalmology

authors： Oku H,Morishita S,Horie T,Nishikawa Y,Kida T,Mimura M,Kojima S,Ikeda T

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between visual disability and visual scores in patients with retinitis pigmentosa. METHODS:The relationship between visual disability and visual scores (visual acuity and visual field) was investigated in 93 patients with retinitis pigmentosa. The visual disability of each patient ...

journal_title：Japanese journal of ophthalmology

authors： Sumi I,Matsumoto S,Okajima O,Shirato S

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:To evaluate the effects of topical latanoprost and timolol in combined therapy on retinal blood flow and tissue circulation in the optic nerve head (ONH) of the cynomolgus monkey. METHODS:Latanoprost (30 microL, 0.005%) was instilled once daily and timolol (30 microL, 0.5%) twice daily for 6 days into 1 eye, a...

journal_title：Japanese journal of ophthalmology

authors： Ishii K,Araie M

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To survey the changes in indications for penetrating keratoplasty (PKP) and re-evaluate the risk factors for allograft rejection and graft failure. METHODS:We evaluated the records of 396 eyes of 335 patients who had undergone PKP at the Tokyo University Hospital between 1987 and 1997. Clinical results were an...

journal_title：Japanese journal of ophthalmology

authors： Inoue K,Amano S,Oshika T,Sawa M,Tsuru T

更新日期：2000-03-01 00:00:00

abstract：:The aqueous humor during or after cataract surgery often contains red blood cells (RBCs) from blood; inflammatory cells from white blood cells (WBCs); fibrin, pigment cells, and fibroblasts from either the iris or the ciliary body; lens epithelial cells (LECs); and corneal endothelial cells. Since LECs may be related ...

journal_title：Japanese journal of ophthalmology

authors： Majima K

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Epidermal nevus syndrome encompasses a group of congenital neurocutaneous anomalies characterized by epidermal nevi in association with cerebral, ocular, and skeletal abnormalities. We report herein the case of a Japanese girl with epidermal nevus syndrome associated with complex ocular choristoma and discus...

journal_title：Japanese journal of ophthalmology

authors： Miyagawa Y,Nakazawa M,Kudoh T

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. METHODS:We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly define...

journal_title：Japanese journal of ophthalmology

authors： Ikesugi K,Ichio T,Tsukitome H,Kondo M

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:We report a patient with a limited form of Wegener's granulomatosis (WG) who presented with ocular changes and an eyelid ulcer in her left eye. CASE:A 56-year-old woman complained of ocular pain and discharge. Upon examination, we found evidence of ulcerative keratitis, a mass in the orbit, and an eyelid sk...

journal_title：Japanese journal of ophthalmology

authors： Kubota T,Hirose H

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To evaluate changes in conjunctival-scleral thickness following strabismus surgery with anterior segment optical coherence tomography (AS-OCT). STUDY DESIGN:Prospective, observational, consecutive case series. METHODS:Distances between the conjunctival epithelium and inner scleral wall were measured with AS-O...

journal_title：Japanese journal of ophthalmology

authors： Suzuki H,Hikoya A,Komori M,Inagaki R,Haseoka T,Arai S,Takagi Y,Hotta Y,Sato M

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To investigate the process of repair in the epithelial cells and the reconstruction in lens fibers of a mouse lens that has developed opacity because of a large-scale perforating injury. METHODS:Lenses of 4-week-old mice were perforated with a needle through the cornea to induce the development of traumatic ca...

journal_title：Japanese journal of ophthalmology

authors： Hirayama S,Wakasugi A,Morita T,Sakai Y,Mukuno K,Uga S,Shimizu K

更新日期：2003-07-01 00:00:00

abstract：:Histochemical studies were carried out in the mouse on the changes and distribution patterns of glycosaminoglycan molecular species during the separation of the lens vesicle. To obtain embryos, pregnant mice of the Jcl:ICR strain were sacrificed on day 10.5 or 11 of pregnancy. Serial frontal sections were strained wit...

journal_title：Japanese journal of ophthalmology

authors： Mizuno S,Ikeda K,Hirabayashi Y

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients. METHODS:Twenty-two eyes from 22 patients w...

journal_title：Japanese journal of ophthalmology

authors： Cho SY,Kim YY,Yoo C,Lee TE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To investigate cytokine mRNA expression during the inflammatory process induced in the contralateral eyes by uniocular inoculation of herpes simplex virus type 1 (HSV-1) via the anterior chamber. METHODS:BALB/c mice were inoculated in the anterior chamber with 5 x 10(4) plaque-forming units of HSV-1 (KOS). mRN...

journal_title：Japanese journal of ophthalmology

authors： Saitoh-Ishibashi K,Ishibashi K,Azumi A,Negi A

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:To investigate whether retinal glial cells (RGCs), which are believed to play an important role in the development and maintenance of microvessels, stimulate the proliferation of retinal bovine microvascular pericytes, an essential component of the vessels. METHODS:Conditioned medium (CM) was collected from a ...

journal_title：Japanese journal of ophthalmology

authors： Ikuno Y,Hibino S,Bando H,Kawasaki Y,Nakamura T,Tano Y

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To investigate the expression of beta-defensin in the ocular surface of a mouse experimental allergic conjunctivitis (EAC) model. METHODS:Mouse beta-defensin (mBD)-1 and -2 mRNA expressed in conjunctival tissue of both the EAC and the control group were analyzed by real-time reverse transcriptase-polymerase ch...

journal_title：Japanese journal of ophthalmology

authors： Ikeda A,Nakanishi Y,Sakimoto T,Shoji J,Sawa M,Nemoto N

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To estimate the effect of sub-Tenon's capsule triamcinolone acetonide injection (STTA) combined with panretinal photocoagulation (PRP) using pattern scan laser (PSL) for high risk non-proliferative diabetic retinopathy (NPDR), in terms of the inflammation and the progression of diabetic macular edema (DME). ST...

journal_title：Japanese journal of ophthalmology

authors： Yamada Y,Takamura Y,Matsumura T,Morioka M,Gozawa M,Inatani M

更新日期：2018-11-01 00:00:00

abstract：:We have adapted intrinsic signal optical imaging of neural activity to the noninvasive functional imaging of the retina. Results to date demonstrate the feasibility and potential of this new method of functional assessment of the retina. In response to visual stimuli, we have imaged reflectance changes in the retina t...

journal_title：Japanese journal of ophthalmology

authors： Ts'o D,Schallek J,Kwon Y,Kardon R,Abramoff M,Soliz P

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To elucidate clinical and angiographic features of retinal manifestations in cat scratch disease. METHODS:Clinical characteristics as well as fluorescein and indocyanine green (ICG) angiographic features were reviewed in 4 consecutive patients with retinal manifestations caused by serologically confirmed cat s...

journal_title：Japanese journal of ophthalmology

authors： Matsuo T,Yamaoka A,Shiraga F,Takasu I,Okanouchi T,Nagayama M,Baba T,Hayashi M,Sarada K

更新日期：2000-03-01 00:00:00

abstract：:Lymphatic sinus-like structures were demonstrated in the choroid of the monkey eye by transmission and scanning electron microscopy. These lymphatic sinus-like structures were lined by fibroblast-like cells with large intercellular gaps. When the specimens were viewed by scanning electron microscopy, the surface morph...

journal_title：Japanese journal of ophthalmology

authors： Sugita A,Inokuchi T

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Ophthalmologists should be aware of the signs and symptoms of anthrax, although it is a rare disease in humans. We report our successful treatment of three patients with cutaneous lesions in the periorbital area. CASES:In this study, we report on the treatment of three female patients who were initially dia...

journal_title：Japanese journal of ophthalmology

authors： Caça I,Cakmak SS,Unlü K,Sakalar YB,KadiroGlu AK

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To evaluate the progressive changes of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma. METHODS:One hundred-fourteen eyes of open-angle glaucoma p...

journal_title：Japanese journal of ophthalmology

authors： Kim HJ,Jeoung JW,Yoo BW,Kim HC,Park KH

更新日期：2017-07-01 00:00:00

abstract：:To investigate the true structural changes in retinal cotton wool spots, serial sections of several blocks of retinal corresponding to cotton wool spots obtained from two hypertensive cases were studied by light and electron microscopy. Occlusion of the feeder arteriole and capillaries, and numerous vacuoles of variou...

journal_title：Japanese journal of ophthalmology

authors： Murata M,Yoshimoto H

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To identify a mutation in the PRPF31 gene in a family (Family K) with autosomal dominant retinitis pigmentosa (adRP) linked to 19q13.4 (RP11) and to find the frequency of mutations in the PRPF31 gene among Japanese families with adRP. METHODS:Genomic DNA specimens were prepared from five symptomatic and two as...

journal_title：Japanese journal of ophthalmology

authors： Taira K,Nakazawa M,Sato M

更新日期：2007-01-01 00:00:00

abstract：:Purpose: We investigated the relationship between the progression of visual field defect and clinical factors in patients with normal-tension glaucoma (NTG).Subjects and Methods: Forty-eight eyes of 48 NTG patients undergoing more than 5-year follow-up were enrolled in this study. Their visual field defects ranged bet...

journal_title：Japanese journal of ophthalmology

authors： Tanaka C,Yamazaki Y,Yokoyama H

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To determine the association of age-related maculopathy susceptibility 2 (ARMS2) gene polymorphisms with the 12-month outcomes of intravitreal aflibercept combined with photodynamic therapy (IVA+PDT) in polypoidal choroidal vasculopathy (PCV). STUDY DESIGN:Interventional cohort study. METHODS:This was a retro...

journal_title：Japanese journal of ophthalmology

authors： Nakai S,Matsumiya W,Miki A,Honda S,Nakamura M

更新日期：2019-09-01 00:00:00

abstract：:Purpose: Acute retinal necrosis (ARN) is caused by varicella zoster virus (VZV) infection. In this study, we investigated the activity of this virus and expressions of some cytokines.Patients and Methods: The expressionof VZV thymidine kinase and some cytokines were investigated by reverse transcriptase-polymerase cha...

journal_title：Japanese journal of ophthalmology

authors： Sato M,Abe T,Tamai M

更新日期：2000-11-01 00:00:00

abstract：:The effects of three sulfhydryl agents on the cytoskeletal systems of cultured human trabecular cells were examined by the immunofluorescence method. Incubation with iodoacetamide or N-ethyl maleimide (10(-6) M, 10(-5) M, and 10(-4) M) caused a marked alteration on the actin and microtubule organization, but had littl...

journal_title：Japanese journal of ophthalmology

authors： Iwamoto Y,Tamura M,Nakatsuka K,Yamanouchi U

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To report three types of heterozygous mutations in the OPA1 gene in five patients from three families with autosomal dominant optic atrophy (ADOA, MIM#165500). METHODS:DNA was extracted from the leukocytes of the peripheral blood. For mtDNA, mutations were examined at positions 11778, 3460 and 14484. For the O...

journal_title：Japanese journal of ophthalmology

authors： Hamahata T,Fujimaki T,Fujiki K,Miyazaki A,Mizota A,Murakami A

更新日期：2012-01-01 00:00:00