Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome.

abstract：PURPOSE:To investigate cytokine mRNA expression during the inflammatory process induced in the contralateral eyes by uniocular inoculation of herpes simplex virus type 1 (HSV-1) via the anterior chamber. METHODS:BALB/c mice were inoculated in the anterior chamber with 5 x 10(4) plaque-forming units of HSV-1 (KOS). mRN...

journal_title：Japanese journal of ophthalmology

authors： Saitoh-Ishibashi K,Ishibashi K,Azumi A,Negi A

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:We previously reported that human conjunctival epithelial cells expressed functioning interleukin-4 receptor α (IL-4Rα). In this study, we investigated whether human corneal epithelial cells also express functioning IL-4Rα. METHODS:The presence of IL-4Rα mRNA and protein in human corneal epithelium was examine...

journal_title：Japanese journal of ophthalmology

authors： Ueta M,Sotozono C,Kinoshita S

更新日期：2011-07-01 00:00:00

abstract：:Localization of carbonic anhydrase (CA) was investigated in the rat eye by light and electron microscopy, and the inhibitory effects on CA distribution in the rat eye were compared between dorzolamide and acetazolamide. The cobalt sulfide histochemical method was used to study the CA localization. Acidic osmification ...

journal_title：Japanese journal of ophthalmology

authors： Terashima H,Suzuki K,Kato K,Sugai N

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To compare the accuracy of postoperative pachymetry between Orbscan II (Bausch & Lomb) scanning-slit corneal topography/pachymetry and the Pentacam (Oculus) rotating Scheimpflug camera. METHODS:Central corneal thickness (CCT) was determined in 24 patients (48 eyes) before and after laser in situ keratomileusis...

journal_title：Japanese journal of ophthalmology

authors： Matsuda J,Hieda O,Kinoshita S

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:The new microemulsion preconcentrate (MEPC) formulation of ciclosporin has been developed to reduce problems in intestinal absorption and to stabilize fluctuations in blood levels. A multicenter, open-label clinical trial of MEPC was conducted to assess its efficacy and safety in Behçet's disease patients with ...

journal_title：Japanese journal of ophthalmology

authors： Fujino Y,Joko S,Masuda K,Yagi I,Kogure M,Sakai J,Usui M,Kotake S,Matsuda H,Ikeda E,Mochizuki M,Nakamura S,Ohno S

更新日期：1999-07-01 00:00:00

abstract：:Cell population and proportion of each component cell type in preretinal membranes formed after retinal detachment were studied by light microscopy (LM) and transmission electron microscopy (TEM). The preretinal membranes were surgically obtained from 20 proliferative vitreoretinopathy (PVR) and 7 macular pucker patie...

journal_title：Japanese journal of ophthalmology

authors： Yamashita H,Hori S,Masuda K

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To verify, by use of data collected by the Japan Glaucoma Society Survey of Bleb-related Infection (JGSSBI), that bleb morphology changes within 12 months of the development of bleb-related infection. METHODS:JGSSBI data from 57 eyes of 57 patients with primary open-angle glaucoma and normal tension glaucoma w...

journal_title：Japanese journal of ophthalmology

authors： Sawada A,Kuwayama Y,Yamamoto T

更新日期：2015-09-01 00:00:00

abstract：:Silicone oil was injected into the eyes of 28 rabbits. Utilizing the specific affinity of osmium tetroxide for lipids, the pathological features and histochemical localization of silicone oil within the retina were studied. This osmium tetroxide technique makes it possible to identify the presence of silicone oil part...

journal_title：Japanese journal of ophthalmology

authors： Shikishima K,Ohki K,Machi N,Sano Y

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To investigate the utility values associated with visual loss due to age-related macular degeneration (AMD) in Japanese patients. METHODS:Utility values in 48 Japanese patients with bilateral exudative AMD were measured using the time trade-off and standard gamble methods. RESULTS:The time trade-off method ut...

journal_title：Japanese journal of ophthalmology

authors： Yanagi Y,Ueta T,Obata R,Iriyama A,Fukuda T,Hashimoto H

更新日期：2011-01-01 00:00:00

abstract：:Management of intraocular tumors, specifically uveal melanoma, is a matter of controversy. The treatment of these ocular neoplasms varies from observation to enucleation, irradiation (cobalt plaque and proton-helium particle) and eye wall resection. Over the last 18 years, we have developed two techniques for surgical...

journal_title：Japanese journal of ophthalmology

authors： Peyman GA,Gremillion CM

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To investigate the frequency of infraorbital nerve enlargement (IONE) in orbital lymphoproliferative disorders, and to show that IONE can contribute to the clinical diagnosis of IgG4-related orbital diseases (IgG4-ROD). SUBJECTS AND METHODS:71 cases in which orbital lymphoproliferative disorders were diagnosed...

journal_title：Japanese journal of ophthalmology

authors： Ohshima K,Sogabe Y,Sato Y

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:To determine whether exposure to ozonated solution alters the morphology of corneal endothelial cells in rats and to examine the protective effect of ascorbic acid. METHODS:The anterior chambers of rat eyes were filled with 4 ppm of ozonated solution. Some were left in that state, while others were flushed out...

journal_title：Japanese journal of ophthalmology

authors： Suzuki H,Sato S,Murano N,Matsui H,Oharazawa H,Takahashi H

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To determine whether P7C3-A20, a proneurogenic neuroprotective agent, can protect the retinal ganglion cells (RGCs) of rats from optic nerve crushing. METHODS:The left optic nerve of 67 rats was crushed, and 5.0 mg/kg/day of P7C3-A20 (crush-P7C3) or its vehicle (crush-placebo) was injected intraperitoneally fo...

journal_title：Japanese journal of ophthalmology

authors： Oku H,Morishita S,Horie T,Nishikawa Y,Kida T,Mimura M,Kojima S,Ikeda T

更新日期：2017-03-01 00:00:00

abstract：:An 18-year-old Japanese boy with optic disk drusen associated with left central retinal artery occlusion was reported. Transient central blurred vision, possibly caused by central retinal artery spasm, was noticed as an initial symptom of optic disk drusen in the left eye. Prolonged and repeated spasm might have given...

journal_title：Japanese journal of ophthalmology

authors： Uehara M,Inomata H,Yamana Y,Taniguchi Y,Tsuji K

更新日期：1982-01-01 00:00:00

abstract：:A nationwide, multicenter study of typical retinitis pigmentosa (RP) was carried out in collaboration with 18 hospitals throughout Japan to obtain current information for genetic counseling. We analyzed the genetic heterogeneity of RP based on the parental consanguinity of 434 probands registered during a 6-month peri...

journal_title：Japanese journal of ophthalmology

authors： Hayakawa M,Fujiki K,Kanai A,Matsumura M,Honda Y,Sakaue H,Tamai M,Sakuma T,Tokoro T,Yura T,Kubota N,Kawano S,Matsui M,Yuzawa M,Oguchi Y,Akeo K,Adachi E,Kimura T,Miyake Y,Horiguchi M,Wakabayashi K,Ishizaka N,Koi

更新日期：1997-01-01 00:00:00

abstract：:Purpose: To evaluate the usefulness of a new fixation monitoring system called gaze tracking in the perimetry of glaucomatous eyes. Subjects and Method: We studied the visual field of 106 eyes in 106 persons, comprising 74 eyes with open-angle glaucoma and 32 eyes with ocular hypertension. Perimetry was performed usin...

journal_title：Japanese journal of ophthalmology

authors： Kunimatsu S,Suzuki Y,Shirato S,Araie M

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To assess the combined estimate of retinal ganglion cell (RGC) count developed by Medeiros et al. as a tool for diagnosis of glaucoma in Japanese patients. STUDY DESIGN:Cross-sectional study. METHODS:Thirty-one eyes of 19 healthy controls and 106 eyes of 70 glaucoma patients underwent standard automated perim...

journal_title：Japanese journal of ophthalmology

authors： Sakamoto M,Mori S,Ueda K,Akashi A,Inoue Y,Kurimoto T,Kanamori A,Yamada Y,Nakamura M

更新日期：2018-01-01 00:00:00

abstract：:It has been reported that keratocytes endocytose foreign particles both in vitro and in vivo, suggesting the active participation of keratocytes in corneal wound healing and host defense mechanism. To understand the cellular response and the fate of engulfed foreign particles, we investigated the changes in the lysoso...

journal_title：Japanese journal of ophthalmology

authors： Mishima H,Ueda A,Nishida T,Otori T

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To evaluate axial length (AL) measurements and refractive outcomes in vitrectomy combined with cataract operation for rhegmatogenous retinal detachment (RRD) with wholly detached macula. STUDY DESIGN:Retrospective, consecutive, comparative, clinical study. METHODS:We reviewed the data of patients treated by v...

journal_title：Japanese journal of ophthalmology

authors： Pak KY,Park KH,Park SW,Byon IS,Lee JE

更新日期：2019-07-01 00:00:00

abstract：:We assessed the function of Endothelin-1 (ET-1) in the development of anterior chamber inflammation in pigmented rabbit eyes. After the injection of ET-1 solution (10(-13), 10(-11), 10(-9), or 10(-7) M, diluted with 300 microL of artificial aqueous humor) into the anterior chamber, the aqueous protein concentration (A...

journal_title：Japanese journal of ophthalmology

authors： Shoji N,Oshika T,Masuda K

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:The involvement of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO). In this study, the concentrations of cytokines and chemokines in the vitreous fluid of eyes with DR and CRVO were measured and com...

journal_title：Japanese journal of ophthalmology

authors： Suzuki Y,Nakazawa M,Suzuki K,Yamazaki H,Miyagawa Y

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To present and compare the long-term results of Dr. Tamcelik's previously described technique of Tenon advancement and duplication with the conventional Ahmed glaucoma valve (AGV) implantation technique in patients with refractory glaucoma. METHODS:This study was a multicenter, retrospective case series that i...

journal_title：Japanese journal of ophthalmology

authors： Tamcelik N,Ozkok A,Sarıcı AM,Atalay E,Yetik H,Gungor K

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:To investigate whether retinal glial cells (RGCs), which are believed to play an important role in the development and maintenance of microvessels, stimulate the proliferation of retinal bovine microvascular pericytes, an essential component of the vessels. METHODS:Conditioned medium (CM) was collected from a ...

journal_title：Japanese journal of ophthalmology

authors： Ikuno Y,Hibino S,Bando H,Kawasaki Y,Nakamura T,Tano Y

更新日期：2002-07-01 00:00:00

abstract：:Retinol-binding protein (RBP) is a plasma protein with a molecular weight of 21,000 synthesized in the hepatocytes, binding with retinol (vitamin A), and transporting retinol to peripheral tissues. Keratomalacia is caused by a deficiency of vitamin A itself and/or protein-calorie malnutrition. In the latter condition,...

journal_title：Japanese journal of ophthalmology

authors： Matsuo T,Matsuo N,Shiraga F,Koide N

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To investigate global protein expression profiles in the retinas of normal and glucocorticoid-induced ocular hypertensive rats by proteomic analysis. METHODS:Ocular hypertension was induced by topical application of dexamethasone (DEX) for 4 weeks. Age-matched untreated rats served as controls. Intraocular pre...

journal_title：Japanese journal of ophthalmology

authors： Miyara N,Shinzato M,Yamashiro Y,Iwamatsu A,Kariya KI,Sawaguchi S

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the usefulness of laser speckle flowgraphy (LSFG) for the differentiation of acute nonarteritic ischemic optic neuropathy (NAION) from anterior optic neuritis (ON). METHODS:To investigate blood flow in the optic disc under normal conditions, NAION, and anterior ON, we c...

journal_title：Japanese journal of ophthalmology

authors： Maekubo T,Chuman H,Nao-I N

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:To determine the association of age-related maculopathy susceptibility 2 (ARMS2) gene polymorphisms with the 12-month outcomes of intravitreal aflibercept combined with photodynamic therapy (IVA+PDT) in polypoidal choroidal vasculopathy (PCV). STUDY DESIGN:Interventional cohort study. METHODS:This was a retro...

journal_title：Japanese journal of ophthalmology

authors： Nakai S,Matsumiya W,Miki A,Honda S,Nakamura M

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:To clarify the usefulness of measuring anterior chamber depth by the IOLMaster for early-stage assessment of the therapeutic effect of steroid pulse therapy in patients with Vogt-Koyanagi-Harada (VKH) syndrome with active uveitis. METHODS:Seven patients with VKH syndrome (three men and four women) participated...

journal_title：Japanese journal of ophthalmology

authors： Otsuki T,Shimizu K,Igarashi A,Kamiya K

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To report on isolated central retinal artery occlusion (CRAO) as an initial presentation in two patients with undiagnosed paroxysmal nocturnal hemoglobinuria (PNH). METHODS:CRAO related to the aggravation of PNH was observed in 2 of 98 consecutive PNH patients for 10 years. Ocular and systemic manifestations w...

journal_title：Japanese journal of ophthalmology

authors： Yang HS,Park SH,Choi JR,Kim JG

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:To describe baseline measures of refraction, accommodation, and heterophoria in Japanese schoolchildren enrolled in a randomized clinical trial that examines whether progressive addition lenses slow myopic progression compared with single-focus lenses. METHODS:Ninety-five children with myopia between -1.25 and...

journal_title：Japanese journal of ophthalmology

authors： Hasebe S,Nonaka F,Nakatsuka C,Ohtsuki H

更新日期：2005-01-01 00:00:00