Abstract:
PURPOSE:To determine the association of age-related maculopathy susceptibility 2 (ARMS2) gene polymorphisms with the 12-month outcomes of intravitreal aflibercept combined with photodynamic therapy (IVA+PDT) in polypoidal choroidal vasculopathy (PCV). STUDY DESIGN:Interventional cohort study. METHODS:This was a retrospective study of 48 consecutive treatment-naïve PCV patients. The patients underwent IVA+PDT as the initial therapy and were followed up for more than 12 months under a pro re nata regimen. The single nucleotide polymorphism (SNP) at rs10490924 in the ARMS2 gene was genotyped using the TaqMan assay. The clinical characteristics and outcomes of IVA+PDT were compared among the 3 genotypes at rs10490924. Multivariate regression analysis was performed to evaluate the influence of the clinical cofactors on the association of rs10490924 with the visual outcome at 12 months after the first IVA+PDT. RESULTS:No significant difference was found in the baseline characteristics among the 3 genotypes (n = 9, 23, and 16 for the GG, GT, and TT genotypes, respectively). All the patients, regardless of genotype, showed a significant improvement in vision, central retinal thickness, and subfoveal choroidal thickness at all time points measured after the initial IVA+PDT. The number of treatments was significantly smaller in the patients with the GG genotype than in those with the GT or the TT genotype. On multivariate logistic regression analysis, the number of the T allele at rs10490924 was significantly associated with the chance of retreatment after the initial IVA+PDT. CONCLUSION:The presence of the G allele at rs10490924 in the ARMS2 gene is likely associated with a lower chance of retreatment after IVA+PDT in patients with PCV.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Nakai S,Matsumiya W,Miki A,Honda S,Nakamura Mdoi
10.1007/s10384-019-00683-6subject
Has Abstractpub_date
2019-09-01 00:00:00pages
389-395issue
5eissn
0021-5155issn
1613-2246pii
10.1007/s10384-019-00683-6journal_volume
63pub_type
杂志文章abstract::It has been reported that keratocytes endocytose foreign particles both in vitro and in vivo, suggesting the active participation of keratocytes in corneal wound healing and host defense mechanism. To understand the cellular response and the fate of engulfed foreign particles, we investigated the changes in the lysoso...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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abstract::The enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase) is one of the important markers for myelin synthesis or demyelination. We measured the CNPase activities in the visual pathway tissues of Lewis strain rats with experimental allergic encephalomyelitis (EAE) induced by inoculation of myelin basic protein f...
journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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doi:
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abstract::The effect of stimulus contrast changes on the binocular visual evoked response (VER) was investigated using pattern reversal VER, dichoptic stimulation, and Fast Fourier Transform. When the stimulus contrast was changed binocularly, the monocular components increased as the contrast increased. The binocular component...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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journal_title:Japanese journal of ophthalmology
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doi:10.1007/s10384-009-0677-4
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journal_title:Japanese journal of ophthalmology
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doi:10.1007/s10384-020-00720-9
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(98)00023-9
更新日期:1998-09-01 00:00:00
abstract:PURPOSE:To clarify the redox states of the aqueous humor and serum in senile cataract patients. METHODS:We analyzed the reduced and oxidized albumin fractions in 58 patients. The patients had no detectable evidence of other eye or systemic diseases and were divided into two age groups (53-75 and 76-96 years). Analysis...
journal_title:Japanese journal of ophthalmology
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doi:10.1007/s10384-010-0877-y
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(01)00468-3
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(97)00111-1
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abstract:PURPOSE:To evaluate the occurrence of hyperemia with, and efficacy of, bimatoprost 0.01 % for patients in Korea previously treated for open-angle glaucoma (OAG; including normal tension glaucoma) or ocular hypertension (OHT). METHODS:In this multicenter, observational study (Asia Pacific Patterns from Early Access of ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10384-015-0392-2
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-008-0629-4
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abstract::Purpose: We have developed a new method for quantification of metamorphopsia and applied it to study distorted vision resulting from epiretinal membrane (ERM).Patients and Methods: We prepared a modified Amsler chart, which was a square grid formed by black lines on a white background with 12 cm on a side and divided ...
journal_title:Japanese journal of ophthalmology
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doi:10.1016/s0021-5155(00)00157-x
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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doi:
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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doi:
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-019-00667-6
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abstract::Glycosaminoglycans (GAG) in pterygium tissues were analyzed and the results were compared with those in the normal human conjunctiva. A marked difference in the GAG composition was found: 78% of the total hexosamines of GAG from pterygium was glucosamine, whereas 98% of those of the conjunctiva was galactosamine. Pter...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(03)00137-0
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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