In vivo effects of prostaglandins on human retinoblastoma cells in nude mice.

Abstract:

:Prostaglandin D2 (PGD2) and 64E, a derivative of PGs, were tested for their capacity to suppress the growth of retinoblastoma in the nude mouse. Ten million cells of an established cell line of human retinoblastoma, Y-79 cells, were transferred subcutaneously into the nude mouse, and after the transferred cells became a tumor with a diameter larger than 7.5 mm, either PGD2 (1, 2, or 4 mg/kg/day) or 64E (4 mg/kg/day) dissolved in Hanks' solution was daily injected subcutaneously near the tumor for 14 days. The estimated tumor weight as defined by the formula of (length) X (width)2/2 was evaluated at various time intervals after the treatment. Although a low dose of PGD2, 1 mg/kg/day, had no effect, higher doses of PGD2 had a clear effect in suppressing the growth of retinoblastoma in the nude mouse. Tumors in 64E-treated animals were also markedly suppressed in their growth. Histological examination revealed that tumors treated with these drugs had a much larger area of necrosis with fewer tumor cells than the tumors in control animals.

journal_name

Jpn J Ophthalmol

authors

Nakamura M,Fujino Y,Mochizuki M,Minoda K,Masuda K

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

608-20

issue

4

eissn

0021-5155

issn

1613-2246

journal_volume

31

pub_type

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