Abstract：
PURPOSE:To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients. METHODS:Twenty-two eyes from 22 patients with POAG were studied. Initially, IOP was measured at the hospital by Goldmann applanation tonometry (GAT) and Icare-ONE rebound tonometry. Each patient was then instructed how to use the Icare-ONE and BP home monitoring devices. IOP and BP were measured at home by the patients, every 4 h, before and 2 weeks after once daily treatment with PF tafluprost (0.0015%) ophthalmic solution. RESULTS:Intraclass correlations between different IOP measurements were greater than 0.8. PF tafluprost reduced mean diurnal IOP significantly for patients with POAG, from 15.7 ± 1.2 mmHg at baseline to 12.5 ± 0.6 mmHg 2 weeks after treatment (p < 0.001). It increased mean diurnal OPP from 48.5 ± 7.3 mmHg at baseline to 51.3 ± 7.0 mmHg post-treatment (p < 0.017). CONCLUSIONS:Icare-ONE enables glaucoma patients to measure their own diurnal IOP fluctuations. Patient-measured Icare-ONE IOP readings showed that PF tafluprost effectively reduced diurnal IOP in eyes with POAG.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Cho SY,Kim YY,Yoo C,Lee TEdoi
10.1007/s10384-015-0413-1subject
Has Abstractpub_date
2016-01-01 00:00:00pages
27-34issue
1eissn
0021-5155issn
1613-2246pii
10.1007/s10384-015-0413-1journal_volume
60pub_type
杂志文章abstract：PURPOSE:To evaluate aqueous flare change patterns following anti-vascular endothelial growth factor therapy for diabetic macular edema (DME) and investigate the relationship between changes in flare values and central macular thickness (CMT). STUDY DESIGN:Retrospective, interventional case series METHODS: A total of 8...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-019-00698-z
更新日期：2020-05-01 00:00:00
abstract：:We evaluated the clinical statistics of a total of 186 patients (101 men and 85 women) with Vogt-Koyanagi-Harada's disease seen in the Uveitis Survey Clinic of the Hokkaido University Hospital during the 18-year period from 1966 to 1983. The annual number of new cases showed some change. More new patients were seen in...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:To compare the progression of posterior vitreous detachment (PVD) during aging among eyes of diabetics with diabetic retinopathy (DR), eyes of diabetics without DR, and eyes of nondiabetics. STUDY DESIGN:Prospective cross-sectional study. METHODS:One-hundred thirty-three diabetic eyes with DR (DR group), 254 ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-020-00720-9
更新日期：2020-03-01 00:00:00
abstract：:Two siblings with Usher syndrome had optic disc mulberry tumors that were photographically documented over a 5-year period. During this period, growth of these tumors was demonstrated. These lesions were reported histologically to be drusen. The existence of presumed optic disc drusen in siblings with Usher syndrome m...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:We reported previously familial hypo-retinol-binding proteinemia in a child who developed keratomalacia during measles infection. In the present study, we characterized serum retinol-binding proteins (RBPs) in the affected family members and compared these RBPs with those in the unaffected family members. Immunoblotti...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:The new microemulsion preconcentrate (MEPC) formulation of ciclosporin has been developed to reduce problems in intestinal absorption and to stabilize fluctuations in blood levels. A multicenter, open-label clinical trial of MEPC was conducted to assess its efficacy and safety in Behçet's disease patients with ...
journal_title：Japanese journal of ophthalmology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0021-5155(99)00025-8
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:Lysophosphatidic acid (LPA), which activates the small guanosine triphosphate (GTP)-binding protein Rho, was previously shown to promote migration of the rabbit corneal epithelium in culture. The signaling pathway responsible for this effect of LPA was examined in this study with a human corneal epithelial (HCE...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-003-0059-2
更新日期：2004-05-01 00:00:00
abstract：:Persistent bullous keratopathy was produced in one eye of a rabbit by anterior chamber irrigation with benzalkonium chloride solution (BAK). Corneal grafts were made from both eyes of another rabbit and they were transplanted to the eye with bullous keratopathy and the normal fellow eye, which served as the control. S...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：PURPOSE:To investigate mutations of causal genes in two affected male siblings of a Japanese family with suspected Leber congenital amaurosis (LCA) and to characterize the related clinical features. METHODS:After obtaining informed consent, genomic DNA was extracted from peripheral blood of the proband and his family ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-014-0339-z
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:To assess the combined estimate of retinal ganglion cell (RGC) count developed by Medeiros et al. as a tool for diagnosis of glaucoma in Japanese patients. STUDY DESIGN:Cross-sectional study. METHODS:Thirty-one eyes of 19 healthy controls and 106 eyes of 70 glaucoma patients underwent standard automated perim...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-017-0540-y
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:The objective of this study is to describe the clinical and immunological aspects observed in patients with both human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis and ocular dryness. METHODS:In 15 such patients, clinical and biological examinations completed with a biops...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(99)00106-9
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:This study evaluated the surgical practice patterns of glaucoma management followed by glaucoma specialists in Japan. METHODS:A survey was administered to 50 glaucoma specialists who were councilors in the Japan Glaucoma Society about surgical preferences and postoperative glaucoma care. RESULTS:All 50 glauco...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-020-00749-w
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:To evaluate changes in conjunctival-scleral thickness following strabismus surgery with anterior segment optical coherence tomography (AS-OCT). STUDY DESIGN:Prospective, observational, consecutive case series. METHODS:Distances between the conjunctival epithelium and inner scleral wall were measured with AS-O...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-018-0609-2
更新日期：2018-09-01 00:00:00
abstract：:Distribution of microglia cells was studied in the normal retina of Wistar rats kept in a specific-pathogen-free condition, using a combined technique of light and electron microscopy with the weak silver carbonate staining method of del Rio-Hortega. Typical microglia cells were found mainly in the inner plexiform lay...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The value of the polymerase chain reaction (PCR) in the diagnosis of stromal herpetic keratitis was examined using tear fluid specimens; the sensitivity of the nested PCR method in detecting the herpes simplex virus (HSV) genome was 1 plaque-forming unit/mL. PCR assay of 72 tear samples from the eyes of 15 patients wi...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To elucidate clinical and angiographic features of retinal manifestations in cat scratch disease. METHODS:Clinical characteristics as well as fluorescein and indocyanine green (ICG) angiographic features were reviewed in 4 consecutive patients with retinal manifestations caused by serologically confirmed cat s...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(99)00195-1
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Interferon alpha-2b (IFN alpha 2b) was recently shown to be effective as an alternative therapy for conjunctival intraepithelial neoplasia (CIN). Herein, we report our successful management of CIN by the use of IFN alpha 2b. CASE:A 73-year-old woman presented with a complaint of irritation due to a tumorous...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(01)00494-4
更新日期：2002-03-01 00:00:00
abstract：PURPOSE:To determine alterations of the photopic negative response (PhNR) in the full-field and focal macular electroretinograms (ERGs) of patients with optic nerve atrophy (ONA). METHODS:Ten eyes of eight patients, five women and three men with a mean age of 55.1 years, with ONA were studied. Thirty-six age-matched c...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-009-0731-2
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To investigate global protein expression profiles in the retinas of normal and glucocorticoid-induced ocular hypertensive rats by proteomic analysis. METHODS:Ocular hypertension was induced by topical application of dexamethasone (DEX) for 4 weeks. Age-matched untreated rats served as controls. Intraocular pre...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-007-0507-5
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:This study examines the impact of cataracts on health-related quality of life (HR-QOL) and health events in the older population. METHODS:The study population consisted of 439 unoperated cataract patients aged 60 years or older who visited any of the facilities affiliated with the Cataract Survey Group of the ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10384-009-0709-0
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To determine changes of visual-field (VF) global indices after cataract surgery and the factors associated with the effect of cataracts on those indices in primary open-angle glaucoma (POAG) patients. METHODS:A retrospective chart review of 60 POAG patients who had undergone phacoemulsification and intraocular...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-016-0467-8
更新日期：2016-11-01 00:00:00
abstract：:A newly developed model of keratoepithelioplasty (KEP) in the rat was used to analyze the effect of anterior chamber-associated immune deviation on the suppression of corneal allograft rejection. The right eyes of Fisher rats received an anterior chamber (AC) injection of lymphocyte suspension from Dark Agouti (DA) ra...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Malassezia species rarely cause keratitis, and, thus, the clinical manifestations of Malassezia keratitis are not well known. CASE:We report the clinical findings in a 70-year-old woman who complained of pain in her left eye. Slit-lamp biomicroscopy showed a corneal ulcer with irregular infiltration, which ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-007-0447-0
更新日期：2007-07-01 00:00:00
abstract：PURPOSE:To evaluate the progressive changes of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma. METHODS:One hundred-fourteen eyes of open-angle glaucoma p...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-017-0511-3
更新日期：2017-07-01 00:00:00
abstract：:Changes in the distribution pattern of chloride ions were studied in the embryonic chicken retinal pigment epithelium (RPE), chloride ions being deposited as silver chloride (AgCl) in the RPE and observed by electron microscope. Before the 7th day after fertilization, the chloride ions did not accumulate anywhere in t...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The exfoliation syndrome is thought to be a very rare disease in China. The clinical features of 11 patients with pseudoexfoliation (PE) and the histopathologic changes in specimens affected by PE were studied. The loss of pigment at the pupillary ruff and the dense pigmentation on the trabecular meshwork were the ear...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:To report optical coherence tomography (OCT) findings of macular edema secondary to retinal arterial macroaneurysms. METHODS:Six eyes with retinal arterial macroaneurysms were retrospectively examined by OCT. All eyes had macular edema without massive macular hemorrhage. Fluorescein angiography was performed i...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-006-0347-0
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:To measure the volume of the anophthalmic orbit in adults who had undergone enucleation during infancy and to determine its growth. METHODS:The orbital volume in 5 adults who had undergone unilateral enucleation during infancy without an orbital implant was measured on x-ray computed tomography images. Compari...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(01)00427-0
更新日期：2001-11-01 00:00:00
abstract：PURPOSE:To perform a retrospective study to evaluate the long-term outcome of systemic cyclosporine treatment as an adjunct to topical corticosteroid treatment after penetrating keratoplasty (PKP). METHODS:Twenty-six high-risk patients (27 eyes) who received systemic cyclosporine following PKP for an average of 5.4 mo...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(01)00339-2
更新日期：2001-07-01 00:00:00
abstract：:We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjögren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the norm...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(97)00072-5
更新日期：1997-09-01 00:00:00
