Abstract:
BACKGROUND:Interferon alpha-2b (IFN alpha 2b) was recently shown to be effective as an alternative therapy for conjunctival intraepithelial neoplasia (CIN). Herein, we report our successful management of CIN by the use of IFN alpha 2b. CASE:A 73-year-old woman presented with a complaint of irritation due to a tumorous lesion in her left eye. Slit-lamp microscope examination revealed a tumorous lesion involving the bulbar and palpebral conjunctiva as well as the limbus, from the 3-o'clock position to the 8-o'clock position. She had already undergone cryotherapy in the same eye in another hospital, twice for a lesion on the lower tarsal conjunctiva and once for a lesion on the upper tarsal conjunctiva. The histological diagnosis had been CIN. OBSERVATIONS:In treating this patient, IFN alpha 2b was injected subconjunctivally twice and also applied as eye drops for 12 weeks. Two weeks after the initial treatment, the tumorous lesion disappeared. During a 1-year follow-up period, no recurrence was noted. CONCLUSION:Topical and subconjunctival IFN alpha 2b is a valuable treatment option for CIN.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Kobayashi A,Yoshita T,Uchiyama K,Shirao Y,Kitagawa K,Fujisawa A,Tseng SCdoi
10.1016/s0021-5155(01)00494-4keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
215-7issue
2eissn
0021-5155issn
1613-2246pii
S0021515501004944journal_volume
46pub_type
杂志文章abstract::We investigated the ocular fundus of (NZWXBXSB) F1 mice, which are considered to be a good model for systemic lupus erythematosus (SLE) with antiphospholipid syndrome. The abnormal fundus findings were documented by fundus photography, and the chorioretinal lesions were studied histopathologically. The incidence of oc...
journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-003-0059-2
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:We investigated by in vivo confocal microscopy alterations in the subepithelial nerve plexus in different types of herpes simplex keratitis (HSK). METHODS:Seventeen patients (seven women and ten men, mean age 63.9 years) with a history of HSK were classified into three groups according to the classification of...
journal_title:Japanese journal of ophthalmology
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doi:10.1007/s10384-011-0068-5
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
abstract::A nationwide, multicenter study of typical retinitis pigmentosa was carried out in collaboration with 13 university hospitals throughout Japan. A total of 253 patients, 122 males and 131 females, with a wide range of ages (mean 48 years), were registered during a two-month period in 1989. Determination of inheritance ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:
更新日期:1993-01-01 00:00:00
abstract::Diabetic retinopathy is a frequent cause of visual impairment in working-age adults (≥ 30 years) and in Japan is most commonly observed in those aged 50-69 years. Diabetic macular edema (DME) is one of the main causes of vision disturbance in diabetic retinopathy, which is a clinically significant microvascular compli...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(02)00538-5
更新日期:2002-09-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(98)00005-7
更新日期:1998-05-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-011-0085-4
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journal_title:Japanese journal of ophthalmology
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doi:
更新日期:1989-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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更新日期:2011-09-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
abstract::Localization of carbonic anhydrase (CA) was investigated in the rat eye by light and electron microscopy, and the inhibitory effects on CA distribution in the rat eye were compared between dorzolamide and acetazolamide. The cobalt sulfide histochemical method was used to study the CA localization. Acidic osmification ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00