Characterization of retinol-binding protein in familial hypo-retinol-binding proteinemia.

abstract：PURPOSE:To determine whether P7C3-A20, a proneurogenic neuroprotective agent, can protect the retinal ganglion cells (RGCs) of rats from optic nerve crushing. METHODS:The left optic nerve of 67 rats was crushed, and 5.0 mg/kg/day of P7C3-A20 (crush-P7C3) or its vehicle (crush-placebo) was injected intraperitoneally fo...

journal_title：Japanese journal of ophthalmology

authors： Oku H,Morishita S,Horie T,Nishikawa Y,Kida T,Mimura M,Kojima S,Ikeda T

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:We report here a patient with bilateral papillomacular retinoschisis with an enlarged glaucomatous optic nerve head cup and a focal lamina cribrosa defect, the findings of our clinical investigations of this case, and the chosen treatment and outcome. DESIGN:This is an observational case report. METHODS:Clini...

journal_title：Japanese journal of ophthalmology

authors： Yoshitake T,Nakanishi H,Setoguchi Y,Kuroda K,Amemiya K,Taniguchi M,Otani A

更新日期：2014-09-01 00:00:00

abstract：:In an attempt to study the effect of change in the intraocular pressure (IOP) on the status of the vitreous-aqueous interface, the effect of topical bunazosin was studied in the rabbit eye using the new Johnson-Maurice method. This entails an intravitreal injection of FITC-dextran and measurements of its concentration...

journal_title：Japanese journal of ophthalmology

authors： Sugiura Y,Araie M

更新日期：1989-01-01 00:00:00

abstract：:We examined ophthalmologically five affected members of a family with type IIa hyperlipoproteinemia. All of them had increased levels of cholesterol and low-density lipoprotein. Corneal arcus was found in three of the five members; a 50-year-old man, a 43-year-old woman and a 13-year-old boy. We believe that the corne...

journal_title：Japanese journal of ophthalmology

authors： Hayasaka S,Honda M,Kitaoka M,Chiba R

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To evaluate dye retention in the fundus after indocyanine green (ICG)-assisted internal limiting membrane peeling. METHODS:Ten eyes with stage 3 or 4 nondiabetic idiopathic macular hole (MH group) and six eyes with diffuse diabetic macular edema (DM group) were studied. The fundus was examined with 780-nm infr...

journal_title：Japanese journal of ophthalmology

authors： Ashikari M,Ozeki H,Tomida K,Sakurai E,Tamai K,Ogura Y

更新日期：2006-07-01 00:00:00

abstract：:We assessed the function of Endothelin-1 (ET-1) in the development of anterior chamber inflammation in pigmented rabbit eyes. After the injection of ET-1 solution (10(-13), 10(-11), 10(-9), or 10(-7) M, diluted with 300 microL of artificial aqueous humor) into the anterior chamber, the aqueous protein concentration (A...

journal_title：Japanese journal of ophthalmology

authors： Shoji N,Oshika T,Masuda K

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To evaluate the effects of anti-alphabeta T cell receptor monoclonal antibody (R73) on the induction of experimental autoimmune uveoretinitis (EAU) in rats. METHODS:Lewis rats in which EAU was induced were treated with R73. All rats were examined for the clinical course of EAU, pathological findings of the glo...

journal_title：Japanese journal of ophthalmology

authors： Inoki T,Yamagami S,Sakai R,Isobe M,Tsuru T,Kawashima H

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:To clarify the usefulness of measuring anterior chamber depth by the IOLMaster for early-stage assessment of the therapeutic effect of steroid pulse therapy in patients with Vogt-Koyanagi-Harada (VKH) syndrome with active uveitis. METHODS:Seven patients with VKH syndrome (three men and four women) participated...

journal_title：Japanese journal of ophthalmology

authors： Otsuki T,Shimizu K,Igarashi A,Kamiya K

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:We present the pathological findings at orbital exenteration in a patient with Wyburn-Mason syndrome who underwent transarterial embolization. CASE:A 31-year-old man with a 10-year history of gradual exacerbation of left exophthalmos and left cheek swelling was found to have facial and orbital arteriovenous...

journal_title：Japanese journal of ophthalmology

authors： Matsuo T,Yanai H,Sugiu K,Tominaga S,Kimata Y

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:We previously reported that human conjunctival epithelial cells expressed functioning interleukin-4 receptor α (IL-4Rα). In this study, we investigated whether human corneal epithelial cells also express functioning IL-4Rα. METHODS:The presence of IL-4Rα mRNA and protein in human corneal epithelium was examine...

journal_title：Japanese journal of ophthalmology

authors： Ueta M,Sotozono C,Kinoshita S

更新日期：2011-07-01 00:00:00

abstract：:We studied family members of 9 patients with falciform retinal fold, and found a number of cases showing features of familial exudative vitreoretinopathy (FEVR) in the fundi. Retinal fold was also seen in the eye of a cousin of the propositus. Three cases with falciform retinal fold were bilateral and 7 cases were uni...

journal_title：Japanese journal of ophthalmology

authors： Nishimura M,Yamana T,Sugino M,Kohno T,Yamana Y,Minei M,Sanui H

更新日期：1983-01-01 00:00:00

abstract：:The proliferative activity of the lens epithelium in the early stages of cataract crisis was investigated in rats and mice using the 3H-thymidine autoradiographic method with the whole-mount preparations of total lens epithelial cells. Three-week-old Sprague-Dawley (SD) rats were given a diet which included galactose ...

journal_title：Japanese journal of ophthalmology

authors： Terubayashi H,Tsuji T,Okamoto S,Ikebe H,Akagi Y

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To assess the changes in the size of muscle fibers and the composition of myosin heavy chain (MyHC) isoforms in the global layer (GL) and the orbital layer (OL) of rabbit rectus extraocular muscle (EOM) after recession. METHODS:The right superior rectus muscles of two rabbits were harvested at 3 days or 1, 2, ...

journal_title：Japanese journal of ophthalmology

authors： Park SC,Kim YT,Kim SA,Oh SY

更新日期：2008-09-01 00:00:00

abstract：:We investigated the ocular fundus of (NZWXBXSB) F1 mice, which are considered to be a good model for systemic lupus erythematosus (SLE) with antiphospholipid syndrome. The abnormal fundus findings were documented by fundus photography, and the chorioretinal lesions were studied histopathologically. The incidence of oc...

journal_title：Japanese journal of ophthalmology

authors： Nakamura A,Yokoyama T,Kodera S,Zhang D,Hirose S,Shirai T,Kanai A

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the usefulness of laser speckle flowgraphy (LSFG) for the differentiation of acute nonarteritic ischemic optic neuropathy (NAION) from anterior optic neuritis (ON). METHODS:To investigate blood flow in the optic disc under normal conditions, NAION, and anterior ON, we c...

journal_title：Japanese journal of ophthalmology

authors： Maekubo T,Chuman H,Nao-I N

更新日期：2013-07-01 00:00:00

abstract：:The morphological appearance and the quantitative analysis of the structure of the macular microvasculature were investigated in 33 normal subjects by fluorescein angiography and stereoscopic mapping techniques. The foveal capillary network was formed by the anastomosis of 4 to 6 groups of terminal arteriolar and veno...

journal_title：Japanese journal of ophthalmology

authors： Wu LZ,Huang ZS,Wu DZ,Chan E

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:We evaluated the use of immunological biomarkers in transconjunctival immunotherapy by using cholera toxin B for treating experimental allergic conjunctivitis in a mouse model. METHODS:Balb/c mice were sensitized using intraperitoneal injections of ovalbumin (OVA) and were then divided into two groups. The fir...

journal_title：Japanese journal of ophthalmology

authors： Oikawa A,Shoji J,Inada N,Sawa M

更新日期：2011-09-01 00:00:00

abstract：:Glycosaminoglycans (GAG) in pterygium tissues were analyzed and the results were compared with those in the normal human conjunctiva. A marked difference in the GAG composition was found: 78% of the total hexosamines of GAG from pterygium was glucosamine, whereas 98% of those of the conjunctiva was galactosamine. Pter...

journal_title：Japanese journal of ophthalmology

authors： Kaneko M,Takaku I,Katsura N

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:A prospective study was conducted to compare the effectiveness, safety, and stability of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) for correction of low to moderate myopia. METHODS:Forty-five patients with a manifest refraction (PRK, -4.54 +/- 0.80; LASIK, -4.82 +/- 1.10) from ...

journal_title：Japanese journal of ophthalmology

authors： Lee JB,Kim JS,Choe C,Seong GJ,Kim EK

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:It is well-known that patients with psychogenic visual disturbances (PVD) exhibit characteristic kinetic visual fields. Even when the kinetic fields are normalized, the static fields of PVD children frequently remain abnormal. To verify this finding, we performed static perimetry on those children whose kinetic...

journal_title：Japanese journal of ophthalmology

authors： Osako M,Harasawa K,Suzuki H,Usui M,Hoshika A

更新日期：2000-09-01 00:00:00

abstract：:The localization of the S-antigen was studied by electron microscopy in the rabbit eye, under three conditions of adaptation: A) 24-hour dark adaptation, B) 24-hour dark adaptation and 1.5-hour light adaptation and C) light adaptation for 30 hours. The Fab' fraction of the IgG of rabbit against the swine S-antigen was...

journal_title：Japanese journal of ophthalmology

authors： Yajima S,Hasemi M,Usui M

更新日期：1985-01-01 00:00:00

abstract：:Purpose: We previously reported that a unique free fluorophore (Fl-Glc), presumably a beta-glucoside, is particularly abundant in human brunescent cataractous lens nuclei. Our preliminary experiments indicated that incubation of low-molecular weight (MW) fraction of non-brunescent lens nuclei causes an increase in a p...

journal_title：Japanese journal of ophthalmology

authors： Ando K,Shirao E,Iwakuchi Y,Shirao Y,Inoue A

更新日期：2000-09-01 00:00:00

abstract：:An 18-year-old Japanese boy with optic disk drusen associated with left central retinal artery occlusion was reported. Transient central blurred vision, possibly caused by central retinal artery spasm, was noticed as an initial symptom of optic disk drusen in the left eye. Prolonged and repeated spasm might have given...

journal_title：Japanese journal of ophthalmology

authors： Uehara M,Inomata H,Yamana Y,Taniguchi Y,Tsuji K

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Vogt-Koyanagi-Harada (VKH) disease is known to have varied manifestations in different ethnic groups. In order to analyze the clinical profile of VKH cases in the Indian population, we studied 87 consecutive cases of VKH disease treated in an uveitis clinic in South India between 1985 and 1996. METHODS:Retrosp...

journal_title：Japanese journal of ophthalmology

authors： Mondkar SV,Biswas J,Ganesh SK

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To evaluate macular shape in normal eyes using swept-source optical coherence tomography (SS-OCT). STUDY DESIGN:Retrospective cross-sectional study. METHODS:We retrospectively evaluated 77 normal eyes of 48 subjects. Curvature of retinal pitment epithelium (RPE) and choroid/scleral interface (CSI) was measure...

journal_title：Japanese journal of ophthalmology

authors： Minami S,Ito Y,Ueno S,Kataoka K,Takeuchi J,Ito H,Nakano Y,Kitagawa M,Leahy C,Straub J,Terasaki H

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To identify a mutation in the PRPF31 gene in a family (Family K) with autosomal dominant retinitis pigmentosa (adRP) linked to 19q13.4 (RP11) and to find the frequency of mutations in the PRPF31 gene among Japanese families with adRP. METHODS:Genomic DNA specimens were prepared from five symptomatic and two as...

journal_title：Japanese journal of ophthalmology

authors： Taira K,Nakazawa M,Sato M

更新日期：2007-01-01 00:00:00

abstract：:A locally aggressive nonteratoid intraocular medulloepithelioma occurring in a two-year-old boy was studied by electron microscopy. For comparison the primitive pars plana region was examined in human fetal eyes obtained at 16, 18 and 22 weeks of gestation. The tumour was polymorphic with neural, intermediate and epit...

journal_title：Japanese journal of ophthalmology

authors： Wakakura M,Lee WR

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to estimate the optimal size of visual field test for detecting longitudinal changes in retinitis pigmentosa (RP) by dividing the visual field. METHODS:We reviewed the results of 10° static visual field tests in 19 eyes of 19 RP patients. Sixty-eight numeric value points were divi...

journal_title：Japanese journal of ophthalmology

authors： Ogino K,Otani A,Oishi A,Kurimoto M,Sekiya T,Yoshimura N

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:To describe baseline measures of refraction, accommodation, and heterophoria in Japanese schoolchildren enrolled in a randomized clinical trial that examines whether progressive addition lenses slow myopic progression compared with single-focus lenses. METHODS:Ninety-five children with myopia between -1.25 and...

journal_title：Japanese journal of ophthalmology

authors： Hasebe S,Nonaka F,Nakatsuka C,Ohtsuki H

更新日期：2005-01-01 00:00:00

abstract：:We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjögren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the norm...

journal_title：Japanese journal of ophthalmology

authors： Hiraoka M,Saito I,Tsubota K,Sugai S,Miyasaka N

更新日期：1997-09-01 00:00:00