当前位置： SCI文献检索 > JAPANESE JOURNAL OF OPHTHALMOLOGY期刊下所有文献 > Correlation between anterior chamber flare changes and diabetic macular edema after intravitreal injection of ranibizumab and aflibercept.

Correlation between anterior chamber flare changes and diabetic macular edema after intravitreal injection of ranibizumab and aflibercept.

Abstract：

PURPOSE:To evaluate aqueous flare change patterns following anti-vascular endothelial growth factor therapy for diabetic macular edema (DME) and investigate the relationship between changes in flare values and central macular thickness (CMT). STUDY DESIGN:Retrospective, interventional case series METHODS: A total of 84 eyes of 62 patients with DME received either intravitreal ranibizumab (IVR; n = 62) or aflibercept (IVA; n = 22). A laser flare photometer (Kowa FM500, Kowa Company, Ltd) was used to measure flare values, and CMT was assessed using optical coherence tomography. Flare values and CMT were measured prior to injection (baseline) and at, 1, 7 and 14 days after injection. RESULTS:Flare values in the IVR group decreased significantly at day 14 (P = 0.001), whereas the IVA group showed a significant increase in flare values at day 1 (P < 0.001). In the IVA group, the baseline flare values were significantly higher in the CMT reduction group than in the non-CMT reduction group (P = 0.035). There was no correlation between changes in flare values and CMT either in the IVA or IVR group. CONCLUSIONS:Flare value changes in patients treated with IVR decreased at day 14 post-injection. This may indicate when the most anti-inflammatory effect was obtained. There was no correlation between changes in flare values and CMT either in the IVA or IVR group; nevertheless, our research suggests that the baseline flare value is a predictive factor for the efficacy of IVA in DME.

journal_name

Jpn J Ophthalmol

journal_title

Japanese journal of ophthalmology

authors

Shiraya T,Kure K,Araki F,Kato S,Kaiya T

doi

10.1007/s10384-019-00698-z

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

250-256

issue

3

eissn

0021-5155

issn

1613-2246

pii

10.1007/s10384-019-00698-z

journal_volume

64

pub_type

杂志文章

相关文献

JAPANESE JOURNAL OF OPHTHALMOLOGY文献大全
  • Expression of alpha- and beta-defensins in human ocular surface tissue.

    abstract：PURPOSE:Defensins are antimicrobial peptides and are classified into three groups, alpha-, beta- and theta-defensins. We investigated the localization of human neutrophil peptides (HNP) 1-3, which are members of the alpha-defensin subfamily, and the expression of human beta-defensin 1 (hBD-1) and hBD-2 in the ocular su...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-004-0163-y

    authors： Ikeda A,Sakimoto T,Shoji J,Sawa M

    更新日期：2005-03-01 00:00:00

  • Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report.

    abstract：PURPOSE:Lymphoproliferative disorders (LPDs) can develop in patients treated with methotrexate (MTX) and usually respond well to MTX withdrawal. Mucosa-associated lymphoid tissue (MALT) lymphoma is a relatively rare type of MTX-LPD. The development of MTX-LPD in the orbit has not been previously described. We here repo...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-016-0439-z

    authors： Kobayashi Y,Kimura K,Fujitsu Y,Shinkawa K,Muta H,Sonoda KH

    更新日期：2016-05-01 00:00:00

  • Annual incidences of visual impairment during 10-year period in Mie prefecture, Japan.

    abstract：PURPOSE:To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. METHODS:We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly define...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10384-017-0517-x

    authors： Ikesugi K,Ichio T,Tsukitome H,Kondo M

    更新日期：2017-07-01 00:00:00

  • New wound-healing model using cultured corneal endothelial cells. 1. Quantitative study of healing process.

    abstract：:A new in vitro model to evaluate the corneal endothelial wound-healing process was developed. Confluent monolayer cell sheets of either rabbit or bovine corneal endothelial cells were cultured on cover slips, the surface of which had been precoated with hydroxyethyl methacrylate (HEMA) except for the 8 mm-diameter are...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Miyata K,Murao M,Sawa M,Tanishima T

    更新日期：1990-01-01 00:00:00

  • Photoprotective effect of yellow-tinted intraocular lenses.

    abstract：PURPOSE:The aim of this study was to experimentally investigate changes in visible light-induced photo-oxidation and to evaluate the inhibitory effect of various acrylic tinted intraocular lenses (IOLs) on photooxidation. METHODS:Three types of nontinted (VA-60BB, HOYA; SA60AT, Alcon; AU-6, Menicon) and tinted (YA-60B...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-008-0620-0

    authors： Mukai K,Matsushima H,Sawano M,Nobori H,Obara Y

    更新日期：2009-01-01 00:00:00

  • Molecular mimicry: uveitis induced in Macaca fascicularis by microbial protein having sequence homology with retinal S-antigen.

    abstract：:S-antigen (S-Ag), a well characterized 45-kDa protein in the photoreceptor cells, induces predominantly T-cell-mediated autoimmune uveitis when injected into experimental animals. Recently, we have shown that native histone H3 protein derived from yeast (Saccharomyces cerevisiae), or a synthetic peptide that is homolo...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Singh VK,Usukura J,Shinohara T

    更新日期：1992-01-01 00:00:00

  • An epidemic of acute hemorrhagic conjunctivitis in the city of Sao Paulo.

    abstract：:This is a clinical and laboratory report on 98 patients with acute viral conjunctivitis who were referred to the Eye Clinic of the Escola Paulista de Medicina of Sao Paulo, Brazil, from February 1983 to February 1984. It was planned with the objective of confirming the importance of adenovirus and enterovirus 70 as et...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Aoki K,Kawana R,Matsumoto I,Maekawa H,Sawada H,Sakurada N,Nobrega MJ,Del Rey Filho M,Belfort R Jr

    更新日期：1987-01-01 00:00:00

  • Acute unilateral inner retinal dysfunction with photophobia: importance of electrodiagnosis.

    abstract：PURPOSE:To establish with negative electroretinogram (ERG) the clinical entity of eight patients with unilateral severe photophobia, essentially normal fundus, good visual acuity, and severe cone and rod dysfunction. STUDY DESIGN:Multicenter retrospective observation case series. METHODS:Comprehensive ophthalmologic ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-020-00780-x

    authors： Hirakata T,Fujinami K,Saito W,Kanda A,Hirakata A,Ishida S,Murakami A,Tsunoda K,Miyake Y

    更新日期：2020-11-12 00:00:00

  • Clinical features and glaucoma according to optic disc size in a South Korean population: the Namil study.

    abstract：PURPOSE:To assess the proportion of glaucomatous eyes based on the association between optic disc (OD) size and its clinical determinants in the resident population of Namil-myon, Central South Korea. METHODS:Of the 1,532 participants in the Namil study, we included 1,410 Koreans (2,734 eyes) with legible fundus photo...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-014-0303-y

    authors： Kang NH,Jun RM,Choi KR,Namil Study group, Korean Glaucoma Society.

    更新日期：2014-03-01 00:00:00

  • Multicenter genetic study of retinitis pigmentosa in Japan: I. Genetic heterogeneity in typical retinitis pigmentosa.

    abstract：:A nationwide, multicenter study of typical retinitis pigmentosa (RP) was carried out in collaboration with 18 hospitals throughout Japan to obtain current information for genetic counseling. We analyzed the genetic heterogeneity of RP based on the parental consanguinity of 434 probands registered during a 6-month peri...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0021-5155(96)00018-4

    authors： Hayakawa M,Fujiki K,Kanai A,Matsumura M,Honda Y,Sakaue H,Tamai M,Sakuma T,Tokoro T,Yura T,Kubota N,Kawano S,Matsui M,Yuzawa M,Oguchi Y,Akeo K,Adachi E,Kimura T,Miyake Y,Horiguchi M,Wakabayashi K,Ishizaka N,Koi

    更新日期：1997-01-01 00:00:00

  • National survey of pellucid marginal corneal degeneration in Japan.

    abstract：PURPOSE:A national survey was conducted in Japan to analyze the clinical characteristics of pellucid marginal corneal degeneration (PMD). METHODS:A questionnaire was sent to all members of the Japan Cornea Society requesting demographic and clinical findings on PMD patients who had been examined between 2008 and 2010....

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10384-016-0462-0

    authors： Shimazaki J,Maeda N,Hieda O,Ohashi Y,Murakami A,Nishida K,Tsubota K,Japan Pellucid Marginal Corneal Degeneration Study Group.

    更新日期：2016-09-01 00:00:00

  • Comparison of two different spectral domain optical coherence tomography devices in the detection of localized retinal nerve fiber layer defects.

    abstract：PURPOSE:To compare the detection of localized retinal nerve fiber layer (RNFL) defects by two different spectral domain optical coherence tomography (SD-OCT) devices. METHODS:Eyes of 42 normal control subjects and 48 patients with a localized RNFL defect on red-free fundus photographs were imaged by the Cirrus (Carl Z...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-013-0239-7

    authors： Kim KE,Ahn SJ,Kim DM

    更新日期：2013-07-01 00:00:00

  • Expression of beta defensins in ocular surface tissue of experimentally developed allergic conjunctivitis mouse model.

    abstract：PURPOSE:To investigate the expression of beta-defensin in the ocular surface of a mouse experimental allergic conjunctivitis (EAC) model. METHODS:Mouse beta-defensin (mBD)-1 and -2 mRNA expressed in conjunctival tissue of both the EAC and the control group were analyzed by real-time reverse transcriptase-polymerase ch...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-005-0262-4

    authors： Ikeda A,Nakanishi Y,Sakimoto T,Shoji J,Sawa M,Nemoto N

    更新日期：2006-01-01 00:00:00

  • Light-evoked changes of glycine-like immunoreactivity in the rat retina.

    abstract：:Glycine is an important inhibitory neurotransmitter in the vertebrate retina. Although many reports of glycine localization by the immunocytochemical method have been published, none has distinguished the neurotransmitter function of glycine from metabolic change. If glycine is the neurotransmitter, it seems that it m...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Nishikawa S,Ishiguro S,Tamai M

    更新日期：1996-01-01 00:00:00

  • Cancer in relatives of retinoblastoma patients.

    abstract：:Medical histories with emphasis on malignant disease were obtained on 1,269 first and second degree relatives of 93 probands with retinoblastoma and on 671 first and second degree relatives of 50 age-matched control children. The number of nonocular malignancies expected to occur in first and second degree relatives o...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Cohen MS,Augsburger JJ,Shields JA,Amsel J,Felberg NT

    更新日期：1989-01-01 00:00:00

  • Disturbance of electrolyte balance in vitreous of chicks with form-deprivation myopia.

    abstract：PURPOSE:To investigate the changes in the electrolyte and protein concentrations in the vitreous of 3-week-old chicks with form-deprivation myopia (FDM). METHODS:FDM was induced in 2-day-old male white leghorn chicks by covering the left eye with a translucent plastic goggle and leaving the right eye uncovered to serv...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(99)00177-x

    authors： Seko Y,Shimokawa H,Pang J,Tokoro T

    更新日期：2000-01-01 00:00:00

  • A novel exon 17 deletion mutation of RPGRIP1 gene in two siblings with Leber congenital amaurosis.

    abstract：PURPOSE:To investigate mutations of causal genes in two affected male siblings of a Japanese family with suspected Leber congenital amaurosis (LCA) and to characterize the related clinical features. METHODS:After obtaining informed consent, genomic DNA was extracted from peripheral blood of the proband and his family ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-014-0339-z

    authors： Suzuki T,Fujimaki T,Yanagawa A,Arai E,Fujiki K,Wada Y,Murakami A

    更新日期：2014-11-01 00:00:00

  • Effect of higher order aberrations on contrast sensitivity function in myopic eyes.

    abstract：PURPOSE:To evaluate the relation between higher order aberrations (HOAs) and contrast sensitivity function (CSF) in a population with myopia. METHODS:In this case series, HOAs were measured in 70 myopic eyes over a 6-mm pupil. Contrast sensitivity was also measured. From the contrast sensitivity data, the area under t...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-009-0677-4

    authors： Feizi S,Karimian F

    更新日期：2009-07-01 00:00:00

  • Anterior chamber angle assessment using gonioscopy and ultrasound biomicroscopy.

    abstract：PURPOSE:Comparison of anterior chamber angle measurements using ultrasound biomicroscopy (UBM) and gonioscopy. METHODS:Five hundred subjects were evaluated for grading of angle width by the Shaffer method. UBM was done in the same group to document angle width, angle opening distance (AOD 500), and anterior chamber de...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-003-0004-4

    authors： Narayanaswamy A,Vijaya L,Shantha B,Baskaran M,Sathidevi AV,Baluswamy S

    更新日期：2004-01-01 00:00:00

  • Influence of lens cortex on postoperative inflammation and cellular deposits on surface of intraocular lenses in rabbit eye.

    abstract：:An animal model was used to evaluate the influence of residual lens cortex on postoperative inflammation and cellular deposits on intraocular lenses (IOLs). Eighteen New Zealand white rabbits underwent bilateral endocapsular phacoemulsification with placement of a one-piece polymethylmethacrylate (PMMA) IOL in the cap...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Tamura M,Monson MC,Davis B,Mamalis N

    更新日期：1991-01-01 00:00:00

  • A case of Vogt-Koyanagi-Harada disease with good visual acuity in spite of subfoveal fold.

    abstract：BACKGROUND:Vogt-Koyanagi-Harada (VKH) disease patients with the complication of subretinal pigmented proliferative tissue tend to have a poor visual prognosis. CASE:We herein report a case of VKH with good visual acuity despite a prominent subretinal fold. OBSERVATIONS:A 24-year-old woman, who experienced several rec...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(03)00146-1

    authors： Noda Y,Sonoda KH,Nakamura T,Kawano YI,Ishibashi T,Inomata H

    更新日期：2003-11-01 00:00:00

  • Intravitreal bevacizumab therapy for idiopathic macular telangiectasia.

    abstract：PURPOSE:To investigate the efficacy of intravitreal bevacizumab for the treatment of idiopathic macular telangiectasia (IMT). METHODS:Ten eyes of eight consecutive patients with IMT were studied. Four eyes had type 1, and six had type 2 IMT according to Yannuzzi's classification. All patients were treated with intravi...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-010-0810-4

    authors： Matsumoto Y,Yuzawa M

    更新日期：2010-07-01 00:00:00

  • Ocular ischemic syndrome in diabetic patients.

    abstract：PURPOSE:Diabetes mellitus aggravates carotid occlusive disease, that can manifest as ocular ischemic syndrome (OIS). Ocular manifestations and visual prognosis of OIS in diabetic patients were retrospectively analyzed. METHODS:Twenty-three consecutive diabetic patients with OIS were divided into two groups according t...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(98)00057-4

    authors： Ino-ue M,Azumi A,Kajiura-Tsukahara Y,Yamamoto M

    更新日期：1999-01-01 00:00:00

  • Takayasu disease on the centenary of its discovery.

    abstract：:Takayasu disease was first reported in 1908 by Mikito Takayasu as "a case of peculiar changes in the central retinal vessels." Because in these patients the pulse of the radial artery is impalpable, investigations focusing on the ischemic symptoms of the upper body were conducted. In 1948, Shimizu and Sano named this ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 传,历史文章,杂志文章

    doi：10.1007/s10384-009-0650-2

    authors： Sugiyama K,Ijiri S,Tagawa S,Shimizu K

    更新日期：2009-03-01 00:00:00

  • Spatial distribution of macular pigment estimated by autofluorescence imaging in elderly Japanese individuals.

    abstract：PURPOSE:To determine the spatial distribution types of macular pigment (MP) in elderly Japanese individuals and to consider their origin. STUDY DESIGN:Observational case series. METHODS:Local MP optical density (MPOD) at some eccentricities and MP volume were measured using the MPOD module of a MultiColor Spectralis ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-020-00716-5

    authors： Obana A,Gohto Y,Sasano H,Gellermann W,Sharifzadeh M,Seto T,Bernstein PS

    更新日期：2020-03-01 00:00:00

  • Repair and reconstruction of the mouse lens after perforating injury.

    abstract：PURPOSE:To investigate the process of repair in the epithelial cells and the reconstruction in lens fibers of a mouse lens that has developed opacity because of a large-scale perforating injury. METHODS:Lenses of 4-week-old mice were perforated with a needle through the cornea to induce the development of traumatic ca...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(03)00075-3

    authors： Hirayama S,Wakasugi A,Morita T,Sakai Y,Mukuno K,Uga S,Shimizu K

    更新日期：2003-07-01 00:00:00

  • Patients with asteroid hyalosis and visible floaters.

    abstract：:Four patients with asteroid hyalosis who complained of seeing multiple spherical floaters were examined. Except for multiple brilliant particles in the gelatinous vitreous, no abnormalities were found by ophthalmoscopic examination. Asteroid bodies usually cause no visual symptoms in most patients. Therefore it is unu...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Noda S,Hayasaka S,Setogawa T

    更新日期：1993-01-01 00:00:00

  • Bevacizumab treatment for choroidal neovascularization due to age-related macular degeneration in Japanese patients.

    abstract：PURPOSE:To assess intravitreal bevacizumab (IVB) for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) in Japanese patients. METHODS:Forty-seven patients treated with IVB for newly diagnosed subfoveal or juxtafoveal CNV (predominantly classic CNV, 15 eyes; minimally classic CNV, 11...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-009-0775-3

    authors： Suzuki M,Gomi F,Sawa M,Tsujikawa M,Sakaguchi H

    更新日期：2010-03-01 00:00:00

  • Characteristics of successful filtering blebs at 1 year after trabeculectomy using swept-source three-dimensional anterior segment optical coherence tomography.

    abstract：PURPOSE:To identify the cross-sectional characteristics of filtering blebs associated with intraocular pressure (IOP) control at 1 year after trabeculectomy with a square scleral flap and a fornix-based conjunctival flap. METHODS:A retrospective consecutive case series study was conducted. Eighty-four eyes of 79 patie...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-017-0504-2

    authors： Narita A,Morizane Y,Miyake T,Seguchi J,Baba T,Shiraga F

    更新日期：2017-05-01 00:00:00

  • Myopia control trial with progressive addition lenses in Japanese schoolchildren: baseline measures of refraction, accommodation, and heterophoria.

    abstract：PURPOSE:To describe baseline measures of refraction, accommodation, and heterophoria in Japanese schoolchildren enrolled in a randomized clinical trial that examines whether progressive addition lenses slow myopic progression compared with single-focus lenses. METHODS:Ninety-five children with myopia between -1.25 and...

    journal_title：Japanese journal of ophthalmology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s10384-004-0131-6

    authors： Hasebe S,Nonaka F,Nakatsuka C,Ohtsuki H

    更新日期：2005-01-01 00:00:00