Abstract：
PURPOSE:To investigate the changes in the electrolyte and protein concentrations in the vitreous of 3-week-old chicks with form-deprivation myopia (FDM). METHODS:FDM was induced in 2-day-old male white leghorn chicks by covering the left eye with a translucent plastic goggle and leaving the right eye uncovered to serve as control. After 19 days the animals were euthanized, and the axial dimensions of the eyes were measured with a caliper in an unfixed condition. The liquid vitreous and aqueous humor were removed by paracentesis, and blood was collected from the jugular vein. Sodium, potassium, and chloride concentrations were determined using ion-selective electrodes. Calcium and phosphate concentrations were determined by colorimetric assays using orthocresol phthalein complexone and bacterial xanthine oxidase, respectively. RESULTS:The concentrations of potassium and phosphate were decreased, whereas chloride concentration was increased in the vitreous of the FDM eyes (P < .01). Sodium and calcium concentrations were similar to those in the control eyes. No significant changes in the concentration of electrolytes were observed in the aqueous humor. No significant differences were found in the protein concentrations in the liquid vitreous, gel vitreous, and aqueous humor. CONCLUSIONS:Form-deprivation induced a significant increase of the volume of the liquid vitreous in the eye of the FDM chick. The increased liquid vitreous of the myopic eye was accompanied by an alteration of the electrolyte balance, by a mechanism that has not yet been clarified.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Seko Y,Shimokawa H,Pang J,Tokoro Tdoi
10.1016/s0021-5155(99)00177-xkeywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
15-9issue
1eissn
0021-5155issn
1613-2246pii
S0021-5155(99)00177-Xjournal_volume
44pub_type
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journal_title：Japanese journal of ophthalmology
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journal_title：Japanese journal of ophthalmology
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journal_title：Japanese journal of ophthalmology
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journal_title：Japanese journal of ophthalmology
pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Japanese journal of ophthalmology
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