Retinal cell death by light damage.

abstract：PURPOSE:To evaluate the clinical significance of 5-S-cysteinyldopa (5-S-CD), a major intermediate in melanin synthesis, as a potential diagnostic tumor marker for uveal malignant melanoma. METHODS:The levels of 5-S-CD in the serum were measured by high-performance liquid chromatography in 16 patients with primary uvea...

journal_title：Japanese journal of ophthalmology

authors： Goto H,Usui M,Wakamatsu K,Ito S

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:To establish a rat glaucoma model with chronic intraocular pressure (IOP) elevation induced by microbeads suspended in sodium sulfate-sodium hyaluronate. METHODS:Chronic elevation of IOP was induced unilaterally by injecting polystyrene microbeads, suspended in 4 % sodium sulfate and 3 % sodium hyaluronate, in...

journal_title：Japanese journal of ophthalmology

authors： Matsumoto Y,Kanamori A,Nakamura M,Negi A

更新日期：2014-05-01 00:00:00

abstract：:The superior colliculus (SC) plays an important role in the transformation of visual and auditory signals into motor commands to generate saccadic eye movements toward the targets. This study investigated the synaptic input patterns from the SC, into vertical eye movement-related superior and inferior rectus motoneuro...

journal_title：Japanese journal of ophthalmology

authors： Sasaki Y,Matsui H,Tamai A

更新日期：1994-01-01 00:00:00

abstract：:Management of intraocular tumors, specifically uveal melanoma, is a matter of controversy. The treatment of these ocular neoplasms varies from observation to enucleation, irradiation (cobalt plaque and proton-helium particle) and eye wall resection. Over the last 18 years, we have developed two techniques for surgical...

journal_title：Japanese journal of ophthalmology

authors： Peyman GA,Gremillion CM

更新日期：1989-01-01 00:00:00

abstract：:To assess the capability of perceiving forms in patients with visual field loss, a concept of functional visual field was introduced based on determinations of the time required for pattern recognition. Two series of stimulus patterns were made of Japanese syllabic hiragana characters drawn with black dots in the back...

journal_title：Japanese journal of ophthalmology

authors： Ikeda F,Ikeda M,Shioiri S,Takao M

更新日期：1985-01-01 00:00:00

abstract：:The clinical and etiological findings in 727 patients with viral conjunctivitis treated from January 1982 through December 1984 at Aoki Eye Clinic in Sapporo, Japan, were presented. The age of the patients ranged from 11 days to 88 years, and the monthly incidences of the disease from 18 to 131 cases, with a clusterin...

journal_title：Japanese journal of ophthalmology

authors： Aoki K,Kawana R,Matsumoto I,Wadell G,de Jong JC

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Full-thickness macular holes usually develop in the elderly population. To the best of our knowledge, there has been no written report of a nontraumatic macular hole in a pediatric patient. CASE:A 10-year-old girl noticed decreased central vision in her left eye without any history of trauma. OBSERVATIONS:...

journal_title：Japanese journal of ophthalmology

authors： Nakano T,Uemura A,Kanda S,Sakamoto T

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:From an early stage, retinitis pigmentosa (RP) patients suffer from night blindness which causes nocturnal mobility difficulties. We created a wearable visual aid that uses a high-performance see-through display, and added a high-sensitivity camera with a complementary metal-oxide-semiconductor sensor. Here, we...

journal_title：Japanese journal of ophthalmology

authors： Ikeda Y,Nakatake S,Funatsu J,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Enaida H,Ishibashi T,Sonoda KH

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To evaluate the effect of tetramethylpyrazine on the elevation of aqueous flare and intraocular pressure (IOP) induced by prostaglandin (PG) E(2) and PGE(2) receptor (EP) agonists. METHODS:PGE(2) or EP agonists (11-deoxy PGE(1), EP(2) agonist; 17-phenyl trinor PGE(2), EP(1) and EP(3) agonist; or sulprostone, E...

journal_title：Japanese journal of ophthalmology

authors： Kitagawa K,Hayasaka S,Nagaki Y,Watanabe K

更新日期：2001-05-01 00:00:00

abstract：:A nationwide, multicenter study of typical retinitis pigmentosa was carried out in collaboration with 13 university hospitals throughout Japan. A total of 253 patients, 122 males and 131 females, with a wide range of ages (mean 48 years), were registered during a two-month period in 1989. Determination of inheritance ...

journal_title：Japanese journal of ophthalmology

authors： Hayakawa M,Matsumura M,Ohba N,Matsui M,Fujiki K,Kanai A,Tamai M,Shiono T,Tokoro T,Akazawa Y

更新日期：1993-01-01 00:00:00

abstract：:An animal model was used to evaluate the influence of residual lens cortex on postoperative inflammation and cellular deposits on intraocular lenses (IOLs). Eighteen New Zealand white rabbits underwent bilateral endocapsular phacoemulsification with placement of a one-piece polymethylmethacrylate (PMMA) IOL in the cap...

journal_title：Japanese journal of ophthalmology

authors： Tamura M,Monson MC,Davis B,Mamalis N

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To evaluate the capability of optical coherence tomography (OCT), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) measurements in glaucoma progression detection. METHODS:The study examined 62 eyes of 37 glaucoma patients observed over a 3-year period. All eyes underwent at least four serial R...

journal_title：Japanese journal of ophthalmology

authors： Tenkumo K,Hirooka K,Baba T,Nitta E,Sato S,Shiraga F

更新日期：2013-09-01 00:00:00

abstract：:Hematoxylin-eosin staining, the TUNEL method for in situ detection of the intranuclear DNA fragmentation, which indicates apoptosis, and electron microscopy were used to study the morphologic changes in specimens from the eyes of 8 patients with secondary glaucoma and 2 normal control eyes to evaluate our hypothesis t...

journal_title：Japanese journal of ophthalmology

authors： Okisaka S,Murakami A,Mizukawa A,Ito J

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:To explore methods of automated visual field (VF) examination for the assessment of macular function. METHOD:We used a VF examination (AP-7000 automatic perimeter, Kowa, Japan) to examine macular function in 53 eyes from 29 patients with open angle glaucoma. We measured the mean total deviation (c-MD) of 16 po...

journal_title：Japanese journal of ophthalmology

authors： Omodaka K,Kunimatsu-Sanuki S,Morin R,Tsuda S,Yokoyama Y,Takahashi H,Maruyama K,Kunikata H,Nakazawa T

更新日期：2013-09-01 00:00:00

abstract：:We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjögren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the norm...

journal_title：Japanese journal of ophthalmology

authors： Hiraoka M,Saito I,Tsubota K,Sugai S,Miyasaka N

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To investigate the efficacy of intravitreal bevacizumab for the treatment of idiopathic macular telangiectasia (IMT). METHODS:Ten eyes of eight consecutive patients with IMT were studied. Four eyes had type 1, and six had type 2 IMT according to Yannuzzi's classification. All patients were treated with intravi...

journal_title：Japanese journal of ophthalmology

authors： Matsumoto Y,Yuzawa M

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To elucidate clinical and angiographic features of retinal manifestations in cat scratch disease. METHODS:Clinical characteristics as well as fluorescein and indocyanine green (ICG) angiographic features were reviewed in 4 consecutive patients with retinal manifestations caused by serologically confirmed cat s...

journal_title：Japanese journal of ophthalmology

authors： Matsuo T,Yamaoka A,Shiraga F,Takasu I,Okanouchi T,Nagayama M,Baba T,Hayashi M,Sarada K

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:This study examines the impact of cataracts on health-related quality of life (HR-QOL) and health events in the older population. METHODS:The study population consisted of 439 unoperated cataract patients aged 60 years or older who visited any of the facilities affiliated with the Cataract Survey Group of the ...

journal_title：Japanese journal of ophthalmology

authors： Yamada M,Mizuno Y,Miyake Y,Cataract Survey Group of the National Hospital Organization of Japan.

更新日期：2009-09-01 00:00:00

abstract：:Full-field electroretinograms (ERGs) provide a basis for establishing the diagnosis of widespread progressive forms of retinitis pigmentosa in early life even at a time when fundus abnormalities visible with the ophthalmoscope are minimal or absent. Patients characteristically show delays in rod or cone b-wave implici...

journal_title：Japanese journal of ophthalmology

authors： Berson EL

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:We investigated the keratocyte response and stromal remodeling after corneal incision and photorefractive keratectomy to understand the histophysiological and immunohistochemical differences between these two types of surgery. METHODS:Corneal incision or photorefractive keratectomy was performed in rabbits or ...

journal_title：Japanese journal of ophthalmology

authors： Tanaka T

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:We previously reported that human conjunctival epithelial cells expressed functioning interleukin-4 receptor α (IL-4Rα). In this study, we investigated whether human corneal epithelial cells also express functioning IL-4Rα. METHODS:The presence of IL-4Rα mRNA and protein in human corneal epithelium was examine...

journal_title：Japanese journal of ophthalmology

authors： Ueta M,Sotozono C,Kinoshita S

更新日期：2011-07-01 00:00:00

abstract：:The effect of pertussis toxin (PT) on experimental autoimmune uveoretinitis (EAU) induced by immunization with S-antigen was examined in rats. Intravenous administration of PT (2 micrograms/rat) initiated the development of EAU in rats that had been made resistant to the induction of EAU by immunization with S-antigen...

journal_title：Japanese journal of ophthalmology

authors： Suzuki I,Takahashi S,Fujii Y,Fuyama S,Arai S

更新日期：1989-01-01 00:00:00

abstract：:We evaluated the clinical statistics of a total of 186 patients (101 men and 85 women) with Vogt-Koyanagi-Harada's disease seen in the Uveitis Survey Clinic of the Hokkaido University Hospital during the 18-year period from 1966 to 1983. The annual number of new cases showed some change. More new patients were seen in...

journal_title：Japanese journal of ophthalmology

authors： Ohno S,Minakawa R,Matsuda H

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To establish with negative electroretinogram (ERG) the clinical entity of eight patients with unilateral severe photophobia, essentially normal fundus, good visual acuity, and severe cone and rod dysfunction. STUDY DESIGN:Multicenter retrospective observation case series. METHODS:Comprehensive ophthalmologic ...

journal_title：Japanese journal of ophthalmology

authors： Hirakata T,Fujinami K,Saito W,Kanda A,Hirakata A,Ishida S,Murakami A,Tsunoda K,Miyake Y

更新日期：2020-11-12 00:00:00

abstract：PURPOSE:The aim of this study was to clarify the demographics, clinical features, and outcomes of Japanese patients with sebaceous carcinoma of the eyelid or conjunctiva. STUDY DESIGN:Retrospective study. METHODS:One hundred twenty-five patients with sebaceous carcinoma of the eyelid or conjunctiva diagnosed at Tokyo...

journal_title：Japanese journal of ophthalmology

authors： Goto H,Tsubota K,Nemoto R,Ueda S,Umazume K,Usui Y,Matsumura H

更新日期：2020-09-01 00:00:00

abstract：:A surgically obtained lens from a 66-year-old man with the Weill-Marchesani syndrome was examined histopathologically by light microscopy, transmission electron microscopy and scanning electron microscopy. The lens was diffusely opaque and brown. It was microspherophakic in appearance, 6.0 mm in equatorial diameter an...

journal_title：Japanese journal of ophthalmology

authors： Nagata M,Takagi S,Yamasaki A,Tsunematsu S,Kumagami T,Itamochi C,Tamai A

更新日期：1995-01-01 00:00:00

abstract：:This is a clinical and laboratory report on 98 patients with acute viral conjunctivitis who were referred to the Eye Clinic of the Escola Paulista de Medicina of Sao Paulo, Brazil, from February 1983 to February 1984. It was planned with the objective of confirming the importance of adenovirus and enterovirus 70 as et...

journal_title：Japanese journal of ophthalmology

authors： Aoki K,Kawana R,Matsumoto I,Maekawa H,Sawada H,Sakurada N,Nobrega MJ,Del Rey Filho M,Belfort R Jr

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To report a patient with agenesis of both internal carotid canals who presented with incomplete oculomotor palsy with pupil sparing. METHODS:The incomplete oculomotor palsy was followed clinically, and the precise anatomical relation of the aneurysm to the subarachnoid oculomotor nerve was investigated during ...

journal_title：Japanese journal of ophthalmology

authors： Takahashi M,Kase M,Suzuki Y,Yokoi M,Kazumata K,Terasaka S

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To describe the clinical features and treatment outcomes of severe retinopathy in eyes with incontinentia pigmenti (IP) of infants within a few months of birth. STUDY DESIGN:Retrospective clinical study. METHODS:Six eyes of three patients (6-day-old girl, 5-month-old girl, and 14-day-old boy) with IP were exa...

journal_title：Japanese journal of ophthalmology

authors： Nakao S,Nishina S,Tanaka S,Yoshida T,Yokoi T,Azuma N

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:To determine whether photoreceptor degeneration in transgenic (Tg) rabbits carrying the Pro347Leu rhodopsin mutation alters the neural activity of the middle and inner retinal neurons. METHODS:Multifocal electroretinograms (mfERGs) were recorded from eight 12-week-old Tg rabbits both before and after intravitr...

journal_title：Japanese journal of ophthalmology

authors： Yokoyama D,Machida S,Kondo M,Terasaki H,Nishimura T,Kurosaka D

更新日期：2010-09-01 00:00:00