Abstract：
PURPOSE:Defensins are antimicrobial peptides and are classified into three groups, alpha-, beta- and theta-defensins. We investigated the localization of human neutrophil peptides (HNP) 1-3, which are members of the alpha-defensin subfamily, and the expression of human beta-defensin 1 (hBD-1) and hBD-2 in the ocular surface tissues. METHODS:Corneal or conjunctival tissues were obtained from 17 patients undergoing surgery. The reasons for surgery were thermal burns (two patients), acid burn (one patient), corneal perforation (one patient), corneal abscess (one patient), and pterygium (two patients). As a control, tissue samples were collected from ten patients undergoing cataract surgery. The samples were examined for HNP 1-3 by immunohistochemical analysis, and for hBD-1 and hBD-2 by the reverse transcriptase-polymerase chain reaction (RT-PCR) method. RESULTS:Results of staining for HNP 1-3 were positive in all of the six tested samples. The RT-PCR method detected hBD-1 mRNA in all samples. However, hBD-2 was detected in only 7 of the 17 samples. In eight of the ten normal conjunctiva samples and in the two samples from conjunctiva with thermal burn or pterygium, hBD-2 mRNA was not detected. CONCLUSIONS:We concluded that HNP 1-3 and hBD-1 are constitutively expressed in the ocular surface. However, hBD-2 may or may not be expressed, depending on the stage of ocular surface diseases.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Ikeda A,Sakimoto T,Shoji J,Sawa Mdoi
10.1007/s10384-004-0163-ykeywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
73-8issue
2eissn
0021-5155issn
1613-2246journal_volume
49pub_type
杂志文章abstract：PURPOSE:Lysophosphatidic acid (LPA), which activates the small guanosine triphosphate (GTP)-binding protein Rho, was previously shown to promote migration of the rabbit corneal epithelium in culture. The signaling pathway responsible for this effect of LPA was examined in this study with a human corneal epithelial (HCE...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
abstract：PURPOSE:To evaluate axial length (AL) measurements and refractive outcomes in vitrectomy combined with cataract operation for rhegmatogenous retinal detachment (RRD) with wholly detached macula. STUDY DESIGN:Retrospective, consecutive, comparative, clinical study. METHODS:We reviewed the data of patients treated by v...
journal_title：Japanese journal of ophthalmology
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doi：10.1007/s10384-019-00667-6
更新日期：2019-07-01 00:00:00
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journal_title：Japanese journal of ophthalmology
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更新日期：1987-01-01 00:00:00
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journal_title：Japanese journal of ophthalmology
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doi：10.1007/s10384-020-00807-3
更新日期：2021-01-09 00:00:00
abstract：:A newly developed model of keratoepithelioplasty (KEP) in the rat was used to analyze the effect of anterior chamber-associated immune deviation on the suppression of corneal allograft rejection. The right eyes of Fisher rats received an anterior chamber (AC) injection of lymphocyte suspension from Dark Agouti (DA) ra...
journal_title：Japanese journal of ophthalmology
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doi：
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:This study was performed to assess the impact of dry eye on patients' quality of life (QOL) and to analyze the association between subjective symptoms and ocular surface findings of dry eye. METHODS:The study population consisted of 158 patients with dry eye aged 20 years or older who visited any of the 15 med...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10384-010-0812-2
更新日期：2010-07-01 00:00:00
abstract：PURPOSE:To analyze the characteristics and clinical manifestations of clinically diagnosed and serologically confirmed ocular toxocariasis in patients. METHODS:Thirty-three eyes of 33 patients diagnosed as having ocular toxocariasis at the Hallym University Medical Center between January 1999 and December 2008 were in...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-010-0909-7
更新日期：2011-03-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-013-0239-7
更新日期：2013-07-01 00:00:00
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journal_title：Japanese journal of ophthalmology
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doi：10.1007/s10384-012-0173-0
更新日期：2012-11-01 00:00:00
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journal_title：Japanese journal of ophthalmology
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,收录出版
doi：10.1007/s10384-013-0252-x
更新日期：2013-09-01 00:00:00
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journal_title：Japanese journal of ophthalmology
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doi：10.1016/s0021-5155(01)00494-4
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(99)00093-3
更新日期：1999-09-01 00:00:00
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journal_title：Japanese journal of ophthalmology
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doi：
更新日期：1988-01-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-005-0320-y
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Ophthalmologists should be aware of the signs and symptoms of anthrax, although it is a rare disease in humans. We report our successful treatment of three patients with cutaneous lesions in the periorbital area. CASES:In this study, we report on the treatment of three female patients who were initially dia...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-003-0047-6
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:To investigate the seasonal variations in myopia progression and axial elongation in Japanese children. METHODS:Ninety-two children who were enrolled in a myopia-control trial and wearing single vision or progressive addition lenses were included in the analyses (mean ± SD age 11.4 ± 1.7 years, mean spherical ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10384-012-0148-1
更新日期：2012-07-01 00:00:00
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更新日期：2004-01-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：
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journal_title：Japanese journal of ophthalmology
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更新日期：2013-09-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-017-0504-2
更新日期：2017-05-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
