Effect of topical dorzolamide on tissue circulation in the rabbit optic nerve head.

Abstract:

PURPOSE:To examine the effect of 1% topical dorzolamide on tissue circulation in the optic nerve head (ONH) of Dutch rabbits. METHODS:A laser speckle tissue circulation analyzer was used. One eye of each rabbit received 1% topical dorzolamide twice daily for 20 days, and the fellow eye received the vehicle in a masked, randomized manner. Intraocular pressure (IOP) was measured every 5 days. The normalized blur (NB) value, a quantitative index of tissue blood flow velocity in the ONH, was measured before treatment and 2 hours after the last instillation on the 20th day. RESULTS:The IOP was lowered by about 2 mm Hg only in the dorzolamide-treated eyes (P < .01). The NB value showed no significant change in either dorzolamide-treated or vehicle-treated eyes. CONCLUSIONS:Long-term topical dorzolamide does not affect the ONH tissue circulation in dorzolamide- and vehicle-treated eyes of Dutch rabbits.

journal_name

Jpn J Ophthalmol

authors

Tamaki Y,Araie M,Muta K

doi

10.1016/s0021-5155(99)00093-3

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

386-91

issue

5

eissn

0021-5155

issn

1613-2246

pii

S0021-5155(99)00093-3

journal_volume

43

pub_type

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