Difference in redox status of serum and aqueous humor in senile cataract patients as monitored via the albumin thiol-redox state.

Abstract:

PURPOSE:To clarify the redox states of the aqueous humor and serum in senile cataract patients. METHODS:We analyzed the reduced and oxidized albumin fractions in 58 patients. The patients had no detectable evidence of other eye or systemic diseases and were divided into two age groups (53-75 and 76-96 years). Analysis was performed with a high-performance liquid chromatographic system with a fluorescence detector. RESULTS:Extremely small amounts of reduced albumin (3.8% and 3.6% in the younger and older groups, respectively) and markedly large amounts of oxidized albumin (96.2% and 96.4%, respectively) were found in the aqueous humor. Moreover, a higher percentage of oxidized albumin, particularly a highly oxidized irreversible form of albumin, was found in the aqueous humor (12.3% and 12.0%) than in the serum (2.4% and 3.0%). CONCLUSIONS:In senile cataract patients with no complications, the redox state of albumin in the aqueous humor differs considerably, both quantitatively and qualitatively, from that in the serum.

journal_name

Jpn J Ophthalmol

authors

Kawai K,Hayashi T,Matsuyama Y,Minami T,Era S

doi

10.1007/s10384-010-0877-y

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

584-8

issue

6

eissn

0021-5155

issn

1613-2246

journal_volume

54

pub_type

杂志文章
  • Vascular reactivities of isolated and perfused human ciliary arteries.

    abstract::The vascular responses to 8 agents, norepinephrine (NE), phenylephrine (PHE), xylazine (XYL), tyramine (TYR), dopamine (DA), 5-hydroxytryptamine (5-HT), prostaglandin F2 alpha (PGF2 alpha) and KCl were examined in human posterior ciliary arteries (HPCAs) which were isolated and perfused with Tyrode's solution gassed w...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Ohkubo H,Chiba S

    更新日期:1988-01-01 00:00:00

  • Effect of 3,3'-iminodipropionitrile on experimental intravitreal proliferation in albino rabbits.

    abstract::The effect of 3,3'-iminodipropionitrile (IDPN) on experimental intravitreal proliferation in albino rabbits was studied by light and electron microscopy. About 2.5 x 10(5) tissue cultured fibroblasts were injected into the vitreous cavity of albino rabbits. Immediately after the injection, phosphate-buffered solution ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Akiyama K

    更新日期:1990-01-01 00:00:00

  • Night-vision aid using see-through display for patients with retinitis pigmentosa.

    abstract:PURPOSE:From an early stage, retinitis pigmentosa (RP) patients suffer from night blindness which causes nocturnal mobility difficulties. We created a wearable visual aid that uses a high-performance see-through display, and added a high-sensitivity camera with a complementary metal-oxide-semiconductor sensor. Here, we...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-018-00644-5

    authors: Ikeda Y,Nakatake S,Funatsu J,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Enaida H,Ishibashi T,Sonoda KH

    更新日期:2019-03-01 00:00:00

  • Retinal pigment epithelium folds as a diagnostic finding of Vogt-Koyanagi-Harada disease.

    abstract:OBJECTIVE:To examine using the folds of the retinal pigment epithelium (RPE) to diagnose Vogt-Koyanagi-Harada (VKH) disease. METHODS:Retrospective clinical review of 57 Japanese patients between July 2005 and April 2009. Optical coherence tomography (OCT), fundus photographs and fluorescein angiography (FA) were studi...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-012-0212-x

    authors: Kato Y,Yamamoto Y,Tabuchi H,Fukushima A

    更新日期:2013-01-01 00:00:00

  • Involvement of mechanical stretch in the gelatinolytic activity of the fibrous sclera of chicks, in vitro.

    abstract:PURPOSE:To investigate the role of mechanical stretch in the regulation of matrix metalloproteinase-2 (MMP-2) in scleral fibroblasts of chick embryos. METHODS:Scleral fibroblasts derived from chick embryos were seeded onto flexible bottom culture plates, and subjected to a pulsatile stretch when the cells became subco...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(01)00451-8

    authors: Fujikura H,Seko Y,Tokoro T,Mochizuki M,Shimokawa H

    更新日期:2002-01-01 00:00:00

  • Posterior vitreous detachment in patients with diabetes mellitus.

    abstract:PURPOSE:To compare the progression of posterior vitreous detachment (PVD) during aging among eyes of diabetics with diabetic retinopathy (DR), eyes of diabetics without DR, and eyes of nondiabetics. STUDY DESIGN:Prospective cross-sectional study. METHODS:One-hundred thirty-three diabetic eyes with DR (DR group), 254 ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-020-00720-9

    authors: Hayashi K,Sato T,Manabe SI,Hirata A,Yoshimura K

    更新日期:2020-03-01 00:00:00

  • Characterization of retinol-binding protein in familial hypo-retinol-binding proteinemia.

    abstract::We reported previously familial hypo-retinol-binding proteinemia in a child who developed keratomalacia during measles infection. In the present study, we characterized serum retinol-binding proteins (RBPs) in the affected family members and compared these RBPs with those in the unaffected family members. Immunoblotti...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Matsuo T,Matsuo N

    更新日期:1988-01-01 00:00:00

  • Annual incidences of visual impairment during 10-year period in Mie prefecture, Japan.

    abstract:PURPOSE:To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. METHODS:We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly define...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10384-017-0517-x

    authors: Ikesugi K,Ichio T,Tsukitome H,Kondo M

    更新日期:2017-07-01 00:00:00

  • Effects of local hypothermia on ischemic eyes in vitrectomy.

    abstract::The effects of local hypothermia on postoperative inflammation, electroretinogram (ERG) and histological changes of the retina were evaluated in experimental vitrectomy in pressure-induced ischemic rabbit eyes. The solutions used for intraocular perfusion were maintained at 8 degrees C, 22 degrees C or 38 degrees C. F...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Tamai K,Toumoto E

    更新日期:1996-01-01 00:00:00

  • Factors associated with increased aqueous flare in psoriasis.

    abstract:PURPOSE:To evaluate the changes in aqueous flare in psoriasis patients and to identify the factors that influence the level of aqueous flare. METHODS:We examined the 68 eyes of 34 psoriasis patients and the 68 eyes of 34 healthy subjects with a laser flare-cell meter. Complete dermatologic and ophthalmic examinations ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(00)00359-2

    authors: Okamoto F,Umebayasi Y,Ohtsuka F,Hommura S

    更新日期:2001-03-01 00:00:00

  • The process of subretinal strand formation.

    abstract::Surgically resected subretinal proliferative tissue (SRP) in proliferative vitreoretinopathy was examined by morphological and immunohistochemical methods. Membranous and strand-like SRPs were observed. Membranous SRP (4 cases) consisted of retinal pigment epithelial cells (RPEs) and a thin layer of extracellular mate...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Okada M,Ogino N,Matsumura M,Honda Y,Nagai Y

    更新日期:1992-01-01 00:00:00

  • Indocyanine green angiographic findings of lacquer cracks in pathologic myopia.

    abstract::Lacquer cracks are thought to represent healed mechanical breaks in the retinal pigment epithelium, Bruch's membrane, and choriocapillaris complex. In this study, we analyzed the indocyanine green (ICG) angiographic features of lacquer cracks and compared them with findings using fluorescein angiography. Complete opht...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(98)00008-2

    authors: Ohno-Matsui K,Morishima N,Ito M,Tokoro T

    更新日期:1998-07-01 00:00:00

  • Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.

    abstract:BACKGROUND:Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained. With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-004-0176-6

    authors: Shimura M,Saito T,Yasuda K,Tamai M

    更新日期:2005-05-01 00:00:00

  • Orbital exenteration after transarterial embolization in a patient with Wyburn-Mason syndrome: pathological findings.

    abstract:BACKGROUND:We present the pathological findings at orbital exenteration in a patient with Wyburn-Mason syndrome who underwent transarterial embolization. CASE:A 31-year-old man with a 10-year history of gradual exacerbation of left exophthalmos and left cheek swelling was found to have facial and orbital arteriovenous...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-008-0563-5

    authors: Matsuo T,Yanai H,Sugiu K,Tominaga S,Kimata Y

    更新日期:2008-07-01 00:00:00

  • Effects and distribution of intravitreally or subretinally injected silicone oil identified in rabbit retina using osmium tetroxide method.

    abstract::Silicone oil was injected into the eyes of 28 rabbits. Utilizing the specific affinity of osmium tetroxide for lipids, the pathological features and histochemical localization of silicone oil within the retina were studied. This osmium tetroxide technique makes it possible to identify the presence of silicone oil part...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Shikishima K,Ohki K,Machi N,Sano Y

    更新日期:1992-01-01 00:00:00

  • Neovascular Maculopathy Associated with Rubella Retinopathy.

    abstract::Background: We report three eyes of two patients with rubella retinopathy which were associated with choroidal neovascularization in the macula.Cases: A 7-year-old girl (case 1) and a 12-year-old girl (case 2) whose mothers had suffered rubella during their pregnancy revealed typical rubella retinopathy in both eyes a...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(00)00266-5

    authors: Hirano K,Tanikawa A,Miyake Y

    更新日期:2000-11-01 00:00:00

  • Proliferative changes of lens epithelial cells in rat and mouse galactose cataracts--examination using whole-mount preparations.

    abstract::The proliferative activity of the lens epithelium in the early stages of cataract crisis was investigated in rats and mice using the 3H-thymidine autoradiographic method with the whole-mount preparations of total lens epithelial cells. Three-week-old Sprague-Dawley (SD) rats were given a diet which included galactose ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Terubayashi H,Tsuji T,Okamoto S,Ikebe H,Akagi Y

    更新日期:1993-01-01 00:00:00

  • A comparative study of latanoprost (Xalatan) and isopropyl unoprostone (Rescula) in normal and glaucomatous monkey eyes.

    abstract::Latanoprost (PhXA41, Xalatan) and isopropyl unoprostone (UF-021, unoprostone, Rescula) two new prostanoid derivatives, have been shown to reduce intraocular pressure (IOP) significantly in patients with glaucoma or ocular hypertension. This study was designed to compare the ocular hypotensive effects of latanoprost an...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(97)00128-7

    authors: Serle JB,Podos SM,Kitazawa Y,Wang RF

    更新日期:1998-03-01 00:00:00

  • Alterations in ultrastructure and c-met expression in a case of ocular epithelial dysplasia following topical mitomycin C treatment.

    abstract:PURPOSE:Topical mitomycin C (MMC) administration is reportedly effective in treating ocular surface neoplasms such as squamous cell carcinoma. We treated a case of ocular epithelial dysplasia that had spread too diffusely to be completely removed. We examined the ultrastructure of and c-met (hepatocyte growth factor re...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(00)00270-7

    authors: Saika S,Miyamoto T,Kawashima Y,Jinza K,Okada Y,Yamanaka O,Ohnishi Y,Ooshima A

    更新日期:2000-11-01 00:00:00

  • Glycosaminoglycans in pterygium tissues and normal conjunctiva.

    abstract::Glycosaminoglycans (GAG) in pterygium tissues were analyzed and the results were compared with those in the normal human conjunctiva. A marked difference in the GAG composition was found: 78% of the total hexosamines of GAG from pterygium was glucosamine, whereas 98% of those of the conjunctiva was galactosamine. Pter...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Kaneko M,Takaku I,Katsura N

    更新日期:1986-01-01 00:00:00

  • Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome.

    abstract:PURPOSE:This study was performed to assess the impact of dry eye on patients' quality of life (QOL) and to analyze the association between subjective symptoms and ocular surface findings of dry eye. METHODS:The study population consisted of 158 patients with dry eye aged 20 years or older who visited any of the 15 med...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10384-010-0812-2

    authors: Mizuno Y,Yamada M,Miyake Y,Dry Eye Survey Group of the National Hospital Organization of Japan.

    更新日期:2010-07-01 00:00:00

  • Histopathological study of microspherophakia in the Weill-Marchesani syndrome.

    abstract::A surgically obtained lens from a 66-year-old man with the Weill-Marchesani syndrome was examined histopathologically by light microscopy, transmission electron microscopy and scanning electron microscopy. The lens was diffusely opaque and brown. It was microspherophakic in appearance, 6.0 mm in equatorial diameter an...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Nagata M,Takagi S,Yamasaki A,Tsunematsu S,Kumagami T,Itamochi C,Tamai A

    更新日期:1995-01-01 00:00:00

  • Changes in conjunctival-scleral thickness after strabismus surgery measured with anterior segment optical coherence tomography.

    abstract:PURPOSE:To evaluate changes in conjunctival-scleral thickness following strabismus surgery with anterior segment optical coherence tomography (AS-OCT). STUDY DESIGN:Prospective, observational, consecutive case series. METHODS:Distances between the conjunctival epithelium and inner scleral wall were measured with AS-O...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-018-0609-2

    authors: Suzuki H,Hikoya A,Komori M,Inagaki R,Haseoka T,Arai S,Takagi Y,Hotta Y,Sato M

    更新日期:2018-09-01 00:00:00

  • Retinal cell death by light damage.

    abstract:PURPOSE:To determine the relationship between apoptotic photoreceptor cell death and the duration of light exposure. METHODS:Ten-week-old male albino rats (Wistar strain) were dark-adapted for 2 days and then exposed to intense light for 12 hours, and 1, 2, 3, 7, 14, 21, and 28 days. The presence of apoptosis was conf...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(99)00011-8

    authors: Aonuma H,Yamazaki R,Watanabe I

    更新日期:1999-05-01 00:00:00

  • A 10-year review of penetrating keratoplasty.

    abstract:PURPOSE:To survey the changes in indications for penetrating keratoplasty (PKP) and re-evaluate the risk factors for allograft rejection and graft failure. METHODS:We evaluated the records of 396 eyes of 335 patients who had undergone PKP at the Tokyo University Hospital between 1987 and 1997. Clinical results were an...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(99)00190-2

    authors: Inoue K,Amano S,Oshika T,Sawa M,Tsuru T

    更新日期:2000-03-01 00:00:00

  • Clinical characteristics and outcomes of open globe injuries in Japan.

    abstract:PURPOSE:To describe the epidemiology and clinical outcomes of open globe injuries (OGIs) in Japan over 10 years, and examine preoperative factors influencing the visual prognosis after surgery. STUDY DESIGN:Retrospective, observational, multicenter case-series study. METHODS:Patients' data were entered into a compute...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10384-018-0638-x

    authors: Okamoto Y,Morikawa S,Okamoto F,Inomoto N,Ishikawa H,Ueda T,Sakamoto T,Sugitani K,Oshika T

    更新日期:2019-01-01 00:00:00

  • A case of non-Hodgkin's lymphoma following long-term corticosteroid therapy for Addison's disease.

    abstract::A 76-year-old Japanese woman had suffered from fatigue, weight loss, and cutaneous hyperpigmentation at the age of 38 years and was diagnosed as having tuberculous Addison's disease. Since then, corticosteroids had been administered effectively as hormonal replacement. At the age of 75 years, the patient presented wit...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(98)00024-0

    authors: Kakiuchi T,Uehara F,Ohba N

    更新日期:1998-09-01 00:00:00

  • Preretinal membrane formation in rabbit eyes after intravitreal transplantation of cultured astrocytes.

    abstract::Astrocytes were cultured from the cerebral cortices of newborn rabbits and were so confirmed by staining of the glial fibrillary acidic protein (GFAP). In Experiment I, the astrocytes of newborn rabbits of both sexes from one mother were pooled and suspended in a culture medium, and approximately 1-2 X 10(4) cells wer...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Mishima N,Yamashita H,Ishii Y,Hori S

    更新日期:1989-01-01 00:00:00

  • Augmented expression of CD44 splice variants in lymphoproliferative disorder of the lacrimal gland in Sjögren's syndrome.

    abstract::We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjögren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the norm...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(97)00072-5

    authors: Hiraoka M,Saito I,Tsubota K,Sugai S,Miyasaka N

    更新日期:1997-09-01 00:00:00

  • Influence of cyclosporin on steroid-induced cataracts after renal transplantation.

    abstract:PURPOSE:To study the effect of cyclosporin (CsA) on steroid-induced cataracts in patients following renal transplantation. METHODS:The subjects comprise 140 patients who had undergone renal transplantation at Kanazawa Medical Hospital. These subjects had received ophthalmologic examinations prior to their surgery and ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(03)00020-0

    authors: Nakamura T,Sasaki H,Nagai K,Fujisawa K,Sasaki K,Suzuki K,Tsugawa R

    更新日期:2003-05-01 00:00:00