Abstract:
PURPOSE:To clarify the redox states of the aqueous humor and serum in senile cataract patients. METHODS:We analyzed the reduced and oxidized albumin fractions in 58 patients. The patients had no detectable evidence of other eye or systemic diseases and were divided into two age groups (53-75 and 76-96 years). Analysis was performed with a high-performance liquid chromatographic system with a fluorescence detector. RESULTS:Extremely small amounts of reduced albumin (3.8% and 3.6% in the younger and older groups, respectively) and markedly large amounts of oxidized albumin (96.2% and 96.4%, respectively) were found in the aqueous humor. Moreover, a higher percentage of oxidized albumin, particularly a highly oxidized irreversible form of albumin, was found in the aqueous humor (12.3% and 12.0%) than in the serum (2.4% and 3.0%). CONCLUSIONS:In senile cataract patients with no complications, the redox state of albumin in the aqueous humor differs considerably, both quantitatively and qualitatively, from that in the serum.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Kawai K,Hayashi T,Matsuyama Y,Minami T,Era Sdoi
10.1007/s10384-010-0877-ysubject
Has Abstractpub_date
2010-11-01 00:00:00pages
584-8issue
6eissn
0021-5155issn
1613-2246journal_volume
54pub_type
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journal_title:Japanese journal of ophthalmology
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