当前位置： SCI文献检索 > JAPANESE JOURNAL OF OPHTHALMOLOGY期刊下所有文献 > A comparative study of latanoprost (Xalatan) and isopropyl unoprostone (Rescula) in normal and glaucomatous monkey eyes.

A comparative study of latanoprost (Xalatan) and isopropyl unoprostone (Rescula) in normal and glaucomatous monkey eyes.

Abstract：

:Latanoprost (PhXA41, Xalatan) and isopropyl unoprostone (UF-021, unoprostone, Rescula) two new prostanoid derivatives, have been shown to reduce intraocular pressure (IOP) significantly in patients with glaucoma or ocular hypertension. This study was designed to compare the ocular hypotensive effects of latanoprost and unoprostone in cynomologus monkeys with glaucoma and characterizes the prostanoid's mechanisms of action in normal cynomolgus monkey eyes. Intraocular pressure was measured daily at 0, 0.5, and 1 hour and hourly for 5 additional hours during 1 baseline day, 1 vehicle-treated day, and 5 days of therapy with either 0.005% latanoprost or 0.12% unoprostone applied twice daily, at 9:30 AM and 3:30 PM, to the glaucomatous eye of eight monkeys with unilateral laser-induced glaucoma. Outflow facility was measured in six normal monkeys 3 hours prior to dosing and 1 hour after unilateral dosing with either drug. Aqueous humor flow rates were measured in six normal monkeys hourly for 4 hours on 1 baseline day and on 1 treatment day beginning 1 hour after administration of either drug to one eye. Intraocular pressure was significantly (P < 0.005) reduced after the first application for 4 hours with latanoprost and for 2 hours with unoprostone, up to 5.4 +/- 0.8 mm Hg (mean +/- SEM) (latanoprost) and 3.8 +/- 0.5 mm Hg (unoprostone). Intraocular pressure was significantly (P < 0.005) reduced for at least 18 hours following each PM dose of latanoprost. Intraocular pressure was not reduced (P > .05) 18 hours after each PM dose of unoprostone. An enhancement of the ocular hypotensive effect was observed from day 1 to day 5 with repeated dosing of either drug. Latanoprost produced a greater magnitude of IOP reduction for a longer duration of time than unoprostone after each application. Neither drug altered outflow facility or aqueous humor flow rates. Latanoprost and unoprostone appear to reduce IOP in monkeys by enhancing uveoscleral outflow. Latanoprost appears to be more efficacious and potent than unoprostone in reducing IOP in glaucomatous monkey eyes.

journal_name

Jpn J Ophthalmol

journal_title

Japanese journal of ophthalmology

authors

Serle JB,Podos SM,Kitazawa Y,Wang RF

doi

10.1016/s0021-5155(97)00128-7

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

95-100

issue

2

eissn

0021-5155

issn

1613-2246

pii

S0021515597001287

journal_volume

42

pub_type

杂志文章

相关文献

JAPANESE JOURNAL OF OPHTHALMOLOGY文献大全
  • Isolated central retinal artery occlusion as an initial presentation of paroxysmal nocturnal hemoglobinuria and successful long-term prevention of systemic thrombosis with eculizumab.

    abstract：PURPOSE:To report on isolated central retinal artery occlusion (CRAO) as an initial presentation in two patients with undiagnosed paroxysmal nocturnal hemoglobinuria (PNH). METHODS:CRAO related to the aggravation of PNH was observed in 2 of 98 consecutive PNH patients for 10 years. Ocular and systemic manifestations w...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章,收录出版

    doi：10.1007/s10384-013-0252-x

    authors： Yang HS,Park SH,Choi JR,Kim JG

    更新日期：2013-09-01 00:00:00

  • Study on the Progression of Visual Field Defect and Clinical Factors in Normal-Tension Glaucoma.

    abstract：:Purpose: We investigated the relationship between the progression of visual field defect and clinical factors in patients with normal-tension glaucoma (NTG).Subjects and Methods: Forty-eight eyes of 48 NTG patients undergoing more than 5-year follow-up were enrolled in this study. Their visual field defects ranged bet...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(00)00334-8

    authors： Tanaka C,Yamazaki Y,Yokoyama H

    更新日期：2001-01-01 00:00:00

  • Comparison of two procedures: photorefractive keratectomy versus laser in situ keratomileusis for low to moderate myopia.

    abstract：PURPOSE:A prospective study was conducted to compare the effectiveness, safety, and stability of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) for correction of low to moderate myopia. METHODS:Forty-five patients with a manifest refraction (PRK, -4.54 +/- 0.80; LASIK, -4.82 +/- 1.10) from ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-5155(01)00406-3

    authors： Lee JB,Kim JS,Choe C,Seong GJ,Kim EK

    更新日期：2001-09-01 00:00:00

  • In vivo effects of prostaglandins on human retinoblastoma cells in nude mice.

    abstract：:Prostaglandin D2 (PGD2) and 64E, a derivative of PGs, were tested for their capacity to suppress the growth of retinoblastoma in the nude mouse. Ten million cells of an established cell line of human retinoblastoma, Y-79 cells, were transferred subcutaneously into the nude mouse, and after the transferred cells became...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Nakamura M,Fujino Y,Mochizuki M,Minoda K,Masuda K

    更新日期：1987-01-01 00:00:00

  • Proliferative changes of lens epithelial cells in rat and mouse galactose cataracts--examination using whole-mount preparations.

    abstract：:The proliferative activity of the lens epithelium in the early stages of cataract crisis was investigated in rats and mice using the 3H-thymidine autoradiographic method with the whole-mount preparations of total lens epithelial cells. Three-week-old Sprague-Dawley (SD) rats were given a diet which included galactose ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Terubayashi H,Tsuji T,Okamoto S,Ikebe H,Akagi Y

    更新日期：1993-01-01 00:00:00

  • Management of diabetic macular edema in Japan: a review and expert opinion.

    abstract：:Diabetic retinopathy is a frequent cause of visual impairment in working-age adults (≥ 30 years) and in Japan is most commonly observed in those aged 50-69 years. Diabetic macular edema (DME) is one of the main causes of vision disturbance in diabetic retinopathy, which is a clinically significant microvascular compli...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章,评审

    doi：10.1007/s10384-017-0537-6

    authors： Terasaki H,Ogura Y,Kitano S,Sakamoto T,Murata T,Hirakata A,Ishibashi T

    更新日期：2018-01-01 00:00:00

  • Incomplete oculomotor palsy with pupil sparing caused by compression of the oculomotor nerve by a posterior communicating posterior cerebral aneurysm.

    abstract：PURPOSE:To report a patient with agenesis of both internal carotid canals who presented with incomplete oculomotor palsy with pupil sparing. METHODS:The incomplete oculomotor palsy was followed clinically, and the precise anatomical relation of the aneurysm to the subarachnoid oculomotor nerve was investigated during ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-007-0481-y

    authors： Takahashi M,Kase M,Suzuki Y,Yokoi M,Kazumata K,Terasaka S

    更新日期：2007-11-01 00:00:00

  • The quality of life in patients with pathologic myopia.

    abstract：PURPOSE:To evaluate the functional status in daily life and the quality of life (QOL) of pathologic myopia patients. METHODS:A cross-sectional study was conducted using data of consecutive pathologic myopia patients (n = 200) and control subjects (n = 144). The influence of the disease on the daily life and the QOL of...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(00)00305-1

    authors： Takashima T,Yokoyama T,Futagami S,Ohno-Matsui K,Tanaka H,Tokoro T,Mochizuki M

    更新日期：2001-01-01 00:00:00

  • Reconsideration of the most appropriate criterion in the lowest classification of vision disability in Japan.

    abstract：PURPOSE:To verify the current Japanese classification of vision disability in regard to visual acuity. METHODS:A questionnaire was sent to 100 ophthalmology services in Japan. Each service was asked to extract 300 of their outpatient records. From these records, patients who had a sum of corrected visual acuity in bot...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10384-011-0081-8

    authors： Nishida T,Ando N,Sado K,Nakadomari S

    更新日期：2011-11-01 00:00:00

  • Retinal glial cells stimulate microvascular pericyte proliferation via fibroblast growth factor and platelet-derived growth factor in vitro.

    abstract：PURPOSE:To investigate whether retinal glial cells (RGCs), which are believed to play an important role in the development and maintenance of microvessels, stimulate the proliferation of retinal bovine microvascular pericytes, an essential component of the vessels. METHODS:Conditioned medium (CM) was collected from a ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(02)00527-0

    authors： Ikuno Y,Hibino S,Bando H,Kawasaki Y,Nakamura T,Tano Y

    更新日期：2002-07-01 00:00:00

  • Falciform retinal fold as sign of familial exudative vitreoretinopathy.

    abstract：:We studied family members of 9 patients with falciform retinal fold, and found a number of cases showing features of familial exudative vitreoretinopathy (FEVR) in the fundi. Retinal fold was also seen in the eye of a cousin of the propositus. Three cases with falciform retinal fold were bilateral and 7 cases were uni...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Nishimura M,Yamana T,Sugino M,Kohno T,Yamana Y,Minei M,Sanui H

    更新日期：1983-01-01 00:00:00

  • Characterization of retinol-binding protein in familial hypo-retinol-binding proteinemia.

    abstract：:We reported previously familial hypo-retinol-binding proteinemia in a child who developed keratomalacia during measles infection. In the present study, we characterized serum retinol-binding proteins (RBPs) in the affected family members and compared these RBPs with those in the unaffected family members. Immunoblotti...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Matsuo T,Matsuo N

    更新日期：1988-01-01 00:00:00

  • Ocular injury caused by an air bag for a driver wearing eyeglasses.

    abstract：BACKGROUND:Although air bags have been shown to reduce the number of fatalities and serious injuries caused by motor vehicle accidents, there have been many reports of air bag-related ocular injuries. We recently treated air bag-related corneal laceration in a patient wearing eyeglasses at the time of a motor accident....

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(99)00007-6

    authors： Tsuda Y,Wakiyama H,Amemiya T

    更新日期：1999-05-01 00:00:00

  • Cancer in relatives of retinoblastoma patients.

    abstract：:Medical histories with emphasis on malignant disease were obtained on 1,269 first and second degree relatives of 93 probands with retinoblastoma and on 671 first and second degree relatives of 50 age-matched control children. The number of nonocular malignancies expected to occur in first and second degree relatives o...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Cohen MS,Augsburger JJ,Shields JA,Amsel J,Felberg NT

    更新日期：1989-01-01 00:00:00

  • Presumed drusen of optic nerve head in siblings with Usher syndrome.

    abstract：:Two siblings with Usher syndrome had optic disc mulberry tumors that were photographically documented over a 5-year period. During this period, growth of these tumors was demonstrated. These lesions were reported histologically to be drusen. The existence of presumed optic disc drusen in siblings with Usher syndrome m...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Shiono T,Noro M,Tamai M

    更新日期：1991-01-01 00:00:00

  • Biological and therapeutic aspects of proliferative vitreoretinopathy.

    abstract：:Conventional vitreoretinal surgery for proliferative vitreoretinopathy is unsatisfactory despite numerous innovations over the past 20 years. Silicone oil injections in this series resulted in 70% reattachment of these end-stage cases, but within twelve months over 90% had no useful visual result. The development of a...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Constable I

    更新日期：1987-01-01 00:00:00

  • Influence of lens cortex on postoperative inflammation and cellular deposits on surface of intraocular lenses in rabbit eye.

    abstract：:An animal model was used to evaluate the influence of residual lens cortex on postoperative inflammation and cellular deposits on intraocular lenses (IOLs). Eighteen New Zealand white rabbits underwent bilateral endocapsular phacoemulsification with placement of a one-piece polymethylmethacrylate (PMMA) IOL in the cap...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Tamura M,Monson MC,Davis B,Mamalis N

    更新日期：1991-01-01 00:00:00

  • Acute unilateral inner retinal dysfunction with photophobia: importance of electrodiagnosis.

    abstract：PURPOSE:To establish with negative electroretinogram (ERG) the clinical entity of eight patients with unilateral severe photophobia, essentially normal fundus, good visual acuity, and severe cone and rod dysfunction. STUDY DESIGN:Multicenter retrospective observation case series. METHODS:Comprehensive ophthalmologic ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-020-00780-x

    authors： Hirakata T,Fujinami K,Saito W,Kanda A,Hirakata A,Ishida S,Murakami A,Tsunoda K,Miyake Y

    更新日期：2020-11-12 00:00:00

  • Laser subepithelial keratomileusis for low to moderate myopia: 6-month follow-up.

    abstract：PURPOSE:To examine the effectiveness, safety, and stability of laser subepithelial keratomileusis (LASEK), a modified photorefractive keratectomy for low to moderate myopia. METHODS:This study evaluated the results of LASEK in 48 myopic patients (84 eyes) with a consecutive 6-month follow-up period. Preoperative myopi...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(02)00473-2

    authors： Lee JB,Choe CM,Seong GJ,Gong HY,Kim EK

    更新日期：2002-05-01 00:00:00

  • In vivo confocal microscopic observations of eyes diagnosed with posterior corneal vesicles.

    abstract：PURPOSE:To determine the morphological characteristics of the cornea in eyes with posterior corneal vesicles (PCV) determined by in vivo confocal microscopy (IVCM). In addition, to compare the morphological characteristics of the corneas of eyes with PCV to those of eyes with posterior polymorphous corneal dystrophy (P...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-016-0473-x

    authors： Shiraishi A,Zheng X,Sakane Y,Hara Y,Hayashi Y

    更新日期：2016-11-01 00:00:00

  • Keratitis caused by a rare fungus, Malassezia restricta.

    abstract：BACKGROUND:Malassezia species rarely cause keratitis, and, thus, the clinical manifestations of Malassezia keratitis are not well known. CASE:We report the clinical findings in a 70-year-old woman who complained of pain in her left eye. Slit-lamp biomicroscopy showed a corneal ulcer with irregular infiltration, which ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-007-0447-0

    authors： Suzuki T,Hori N,Miyake T,Hori Y,Mochizuki K

    更新日期：2007-07-01 00:00:00

  • Posterior syphilitic uveitis: clinical characteristics, co-infection with HIV, response to treatment.

    abstract：PURPOSE:To describe the characteristics and clinical course of patients with active posterior syphilitic uveitis evaluated between 1991 and 2009. METHODS:Retrospective chart review. RESULTS:Thirteen patients with active posterior syphilitic uveitis were identified at a single institution. All were men, and all with a...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-011-0053-z

    authors： Li SY,Birnbaum AD,Tessler HH,Goldstein DA

    更新日期：2011-09-01 00:00:00

  • Pharmacokinetics of topically applied ciprofloxacin in rabbit tears.

    abstract：:Fluoroquinolones provide an important single antibiotic therapy for bacterial keratitis caused by Staphylococcus aureus and numerous gram-negative bacteria, including Pseudomonas aeruginosa. The pharmacokinetics of three ocular fluoroquinolones, norfloxacin (CHIBOXIN, Merck, Sharp & Dohme), ciprofloxacin (CILOXAN, Alc...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Green LC,Callegan MC,Engel LS,Shimomura Y,Jasheway DW,O'Callaghan RJ,Hill JM

    更新日期：1996-01-01 00:00:00

  • The process of subretinal strand formation.

    abstract：:Surgically resected subretinal proliferative tissue (SRP) in proliferative vitreoretinopathy was examined by morphological and immunohistochemical methods. Membranous and strand-like SRPs were observed. Membranous SRP (4 cases) consisted of retinal pigment epithelial cells (RPEs) and a thin layer of extracellular mate...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Okada M,Ogino N,Matsumura M,Honda Y,Nagai Y

    更新日期：1992-01-01 00:00:00

  • Clinical features and glaucoma according to optic disc size in a South Korean population: the Namil study.

    abstract：PURPOSE:To assess the proportion of glaucomatous eyes based on the association between optic disc (OD) size and its clinical determinants in the resident population of Namil-myon, Central South Korea. METHODS:Of the 1,532 participants in the Namil study, we included 1,410 Koreans (2,734 eyes) with legible fundus photo...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1007/s10384-014-0303-y

    authors： Kang NH,Jun RM,Choi KR,Namil Study group, Korean Glaucoma Society.

    更新日期：2014-03-01 00:00:00

  • Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized controlled trial.

    abstract：PURPOSE:Novel spectacle lenses (MyoVision, Carl Zeiss) designed to reduce relative peripheral hyperopia have been developed and reported to be effective for preventing myopia progression in a subgroup of Chinese children. In this study we examined the efficacy of MyoVision lenses in Japanese children. STUDY DESIGN:Thi...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s10384-018-0616-3

    authors： Kanda H,Oshika T,Hiraoka T,Hasebe S,Ohno-Matsui K,Ishiko S,Hieda O,Torii H,Varnas SR,Fujikado T

    更新日期：2018-09-01 00:00:00

  • The relationship between visual disability and visual scores in patients with retinitis pigmentosa.

    abstract：PURPOSE:To evaluate the relationship between visual disability and visual scores in patients with retinitis pigmentosa. METHODS:The relationship between visual disability and visual scores (visual acuity and visual field) was investigated in 93 patients with retinitis pigmentosa. The visual disability of each patient ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(99)00171-9

    authors： Sumi I,Matsumoto S,Okajima O,Shirato S

    更新日期：2000-01-01 00:00:00

  • Successful management of conjunctival intraepithelial neoplasia by interferon alpha-2b.

    abstract：BACKGROUND:Interferon alpha-2b (IFN alpha 2b) was recently shown to be effective as an alternative therapy for conjunctival intraepithelial neoplasia (CIN). Herein, we report our successful management of CIN by the use of IFN alpha 2b. CASE:A 73-year-old woman presented with a complaint of irritation due to a tumorous...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(01)00494-4

    authors： Kobayashi A,Yoshita T,Uchiyama K,Shirao Y,Kitagawa K,Fujisawa A,Tseng SC

    更新日期：2002-03-01 00:00:00

  • Subclinical optic neuropathy in Graves' orbitopathy.

    abstract：PURPOSE:The aims of the study were to detect early changes in the optic nerve function of patients with Graves' orbitopathy (GrO) who do not have any signs and symptoms of optic neuropathy, using pattern visual evoked potentials (P-VEP), and investigate any possible relation between the disease activity and P-VEP P100 ...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0021-5155(03)00101-1

    authors： Acaroğlu G,Simşek T,Ozalp S,Mutluay A

    更新日期：2003-09-01 00:00:00

  • The motoneurons innervating the musculus levator palpebrae superiors in the monkey, cat and rabbit.

    abstract：:The motoneurons innervating the musculus levator palpebrae superioris (LPS) of the monkey, the cat and the rabbit were studied using horseradish peroxidase (HRP). Furthermore, LPS motoneurons of the cat and rabbit were studied by the double-labeling method using two fluorescent dyes as retrograde neuronal tracers. Aft...

    journal_title：Japanese journal of ophthalmology

    pub_type： 杂志文章

    doi：

    authors： Hiramoto D,Sekiya H,Kojima Y,Mukuno K,Ishikawa S

    更新日期：1995-01-01 00:00:00