Biological and therapeutic aspects of proliferative vitreoretinopathy.

abstract：PURPOSE:In a previous study we demonstrated that the progression of the disease retinitis pigmentosa (RP) can be readily monitored by the mean deviation (MD) measured by Humphrey central 10-2 perimetry, which assesses the sensitivity distribution in the macular area in eyes affected by RP. In the present study, we inve...

journal_title：Japanese journal of ophthalmology

authors： Abe K,Iijima H,Hirakawa H,Tsukahara Y,Toda Y

更新日期：2002-09-01 00:00:00

abstract：:S-antigen (S-Ag), a well characterized 45-kDa protein in the photoreceptor cells, induces predominantly T-cell-mediated autoimmune uveitis when injected into experimental animals. Recently, we have shown that native histone H3 protein derived from yeast (Saccharomyces cerevisiae), or a synthetic peptide that is homolo...

journal_title：Japanese journal of ophthalmology

authors： Singh VK,Usukura J,Shinohara T

更新日期：1992-01-01 00:00:00

abstract：:An animal model was used to evaluate the influence of residual lens cortex on postoperative inflammation and cellular deposits on intraocular lenses (IOLs). Eighteen New Zealand white rabbits underwent bilateral endocapsular phacoemulsification with placement of a one-piece polymethylmethacrylate (PMMA) IOL in the cap...

journal_title：Japanese journal of ophthalmology

authors： Tamura M,Monson MC,Davis B,Mamalis N

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To survey the changes in indications for penetrating keratoplasty (PKP) and re-evaluate the risk factors for allograft rejection and graft failure. METHODS:We evaluated the records of 396 eyes of 335 patients who had undergone PKP at the Tokyo University Hospital between 1987 and 1997. Clinical results were an...

journal_title：Japanese journal of ophthalmology

authors： Inoue K,Amano S,Oshika T,Sawa M,Tsuru T

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To establish a rat glaucoma model with chronic intraocular pressure (IOP) elevation induced by microbeads suspended in sodium sulfate-sodium hyaluronate. METHODS:Chronic elevation of IOP was induced unilaterally by injecting polystyrene microbeads, suspended in 4 % sodium sulfate and 3 % sodium hyaluronate, in...

journal_title：Japanese journal of ophthalmology

authors： Matsumoto Y,Kanamori A,Nakamura M,Negi A

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:To determine whether exposure to ozonated solution alters the morphology of corneal endothelial cells in rats and to examine the protective effect of ascorbic acid. METHODS:The anterior chambers of rat eyes were filled with 4 ppm of ozonated solution. Some were left in that state, while others were flushed out...

journal_title：Japanese journal of ophthalmology

authors： Suzuki H,Sato S,Murano N,Matsui H,Oharazawa H,Takahashi H

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To perform a retrospective study to evaluate the long-term outcome of systemic cyclosporine treatment as an adjunct to topical corticosteroid treatment after penetrating keratoplasty (PKP). METHODS:Twenty-six high-risk patients (27 eyes) who received systemic cyclosporine following PKP for an average of 5.4 mo...

journal_title：Japanese journal of ophthalmology

authors： Inoue K,Kimura C,Amano S,Sato T,Fujita N,Kagaya F,Kaji Y,Tsuru T,Araie M

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To evaluate changes in conjunctival-scleral thickness following strabismus surgery with anterior segment optical coherence tomography (AS-OCT). STUDY DESIGN:Prospective, observational, consecutive case series. METHODS:Distances between the conjunctival epithelium and inner scleral wall were measured with AS-O...

journal_title：Japanese journal of ophthalmology

authors： Suzuki H,Hikoya A,Komori M,Inagaki R,Haseoka T,Arai S,Takagi Y,Hotta Y,Sato M

更新日期：2018-09-01 00:00:00

abstract：:A new in vitro model to evaluate the corneal endothelial wound-healing process was developed. Confluent monolayer cell sheets of either rabbit or bovine corneal endothelial cells were cultured on cover slips, the surface of which had been precoated with hydroxyethyl methacrylate (HEMA) except for the 8 mm-diameter are...

journal_title：Japanese journal of ophthalmology

authors： Miyata K,Murao M,Sawa M,Tanishima T

更新日期：1990-01-01 00:00:00

abstract：:Persistent bullous keratopathy was produced in one eye of a rabbit by anterior chamber irrigation with benzalkonium chloride solution (BAK). Corneal grafts were made from both eyes of another rabbit and they were transplanted to the eye with bullous keratopathy and the normal fellow eye, which served as the control. S...

journal_title：Japanese journal of ophthalmology

authors： Yang HJ,Sato T,Matsubara M,Tanishima T

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Remodeling of the extracellular matrix occurs in the lamina cribrosa in progressed glaucomatous optic nerve damage including disc cupping. We examined immunohistochemical changes in the transforming growth factor (TGF)-beta and platelet-derived growth factor (PDGF) in the optic nerve head in an experimentally i...

journal_title：Japanese journal of ophthalmology

authors： Fukuchi T,Ueda J,Hanyu T,Abe H,Sawaguchi S

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To evaluate the capability of optical coherence tomography (OCT), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) measurements in glaucoma progression detection. METHODS:The study examined 62 eyes of 37 glaucoma patients observed over a 3-year period. All eyes underwent at least four serial R...

journal_title：Japanese journal of ophthalmology

authors： Tenkumo K,Hirooka K,Baba T,Nitta E,Sato S,Shiraga F

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to clarify the demographics, clinical features, and outcomes of Japanese patients with sebaceous carcinoma of the eyelid or conjunctiva. STUDY DESIGN:Retrospective study. METHODS:One hundred twenty-five patients with sebaceous carcinoma of the eyelid or conjunctiva diagnosed at Tokyo...

journal_title：Japanese journal of ophthalmology

authors： Goto H,Tsubota K,Nemoto R,Ueda S,Umazume K,Usui Y,Matsumura H

更新日期：2020-09-01 00:00:00

abstract：:We reported previously familial hypo-retinol-binding proteinemia in a child who developed keratomalacia during measles infection. In the present study, we characterized serum retinol-binding proteins (RBPs) in the affected family members and compared these RBPs with those in the unaffected family members. Immunoblotti...

journal_title：Japanese journal of ophthalmology

authors： Matsuo T,Matsuo N

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To determine changes of visual-field (VF) global indices after cataract surgery and the factors associated with the effect of cataracts on those indices in primary open-angle glaucoma (POAG) patients. METHODS:A retrospective chart review of 60 POAG patients who had undergone phacoemulsification and intraocular...

journal_title：Japanese journal of ophthalmology

authors： Seol BR,Jeoung JW,Park KH

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To determine alterations of the photopic negative response (PhNR) in the full-field and focal macular electroretinograms (ERGs) of patients with optic nerve atrophy (ONA). METHODS:Ten eyes of eight patients, five women and three men with a mean age of 55.1 years, with ONA were studied. Thirty-six age-matched c...

journal_title：Japanese journal of ophthalmology

authors： Tamada K,Machida S,Yokoyama D,Kurosaka D

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To investigate the efficacy of intravitreal bevacizumab for the treatment of idiopathic macular telangiectasia (IMT). METHODS:Ten eyes of eight consecutive patients with IMT were studied. Four eyes had type 1, and six had type 2 IMT according to Yannuzzi's classification. All patients were treated with intravi...

journal_title：Japanese journal of ophthalmology

authors： Matsumoto Y,Yuzawa M

更新日期：2010-07-01 00:00:00

abstract：:The usefulness of the Fluorotron Master fluorophotometer fitted with a small animal adapter was evaluated with tree shrews. We also determined that the optimal measurement parameters for these animals, which are regarded as promising for experimental use in ophthalmic research, are: fluorescein-Na concentration, 0.5 x...

journal_title：Japanese journal of ophthalmology

authors： Ishiko S,Yoshida A,Kitaya N,Abiko T,Mori F,Kado M,Takahashi M,Saito K

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The objective of this study is to describe the clinical and immunological aspects observed in patients with both human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis and ocular dryness. METHODS:In 15 such patients, clinical and biological examinations completed with a biops...

journal_title：Japanese journal of ophthalmology

authors： Merle H,Cabre P,Smadja D,Josset P,Landau M,Vernant JC

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:To elucidate clinical and angiographic features of retinal manifestations in cat scratch disease. METHODS:Clinical characteristics as well as fluorescein and indocyanine green (ICG) angiographic features were reviewed in 4 consecutive patients with retinal manifestations caused by serologically confirmed cat s...

journal_title：Japanese journal of ophthalmology

authors： Matsuo T,Yamaoka A,Shiraga F,Takasu I,Okanouchi T,Nagayama M,Baba T,Hayashi M,Sarada K

更新日期：2000-03-01 00:00:00

abstract：:A case of unilateral disc-shaped cataract with coloboma of the lens is reported. The patient, a 17-year-old girl, had best corrected visual acuity of 0.01 (+ 9 D) in the right eye and 1.2 in the left eye. Exotropia of 10 Hirschberg degrees was found in her right eye. The visual disturbance of that eye was thought to b...

journal_title：Japanese journal of ophthalmology

authors： Kihara Y,Shimomura Y,Omoto T,Fukuda M

更新日期：1988-01-01 00:00:00

abstract：:The protective effect of geraniin (tannin from Geranium thunbergii) against oxidative damage was examined in the mouse ocular lens. Oxidative damage in the lens was induced by diamide, diazene dicarboxylic acid bis (N,N-dimethylamide); diamide oxidized the sulfhydryl groups in both the membrane and cytoplasm but did n...

journal_title：Japanese journal of ophthalmology

authors： Fukaya Y,Nakazawa K,Okuda T,Iwata S

更新日期：1988-01-01 00:00:00

abstract：:Prostaglandin D2 (PGD2) and 64E, a derivative of PGs, were tested for their capacity to suppress the growth of retinoblastoma in the nude mouse. Ten million cells of an established cell line of human retinoblastoma, Y-79 cells, were transferred subcutaneously into the nude mouse, and after the transferred cells became...

journal_title：Japanese journal of ophthalmology

authors： Nakamura M,Fujino Y,Mochizuki M,Minoda K,Masuda K

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:This study was performed to assess the impact of dry eye on patients' quality of life (QOL) and to analyze the association between subjective symptoms and ocular surface findings of dry eye. METHODS:The study population consisted of 158 patients with dry eye aged 20 years or older who visited any of the 15 med...

journal_title：Japanese journal of ophthalmology

authors： Mizuno Y,Yamada M,Miyake Y,Dry Eye Survey Group of the National Hospital Organization of Japan.

更新日期：2010-07-01 00:00:00

abstract：:Two siblings with Usher syndrome had optic disc mulberry tumors that were photographically documented over a 5-year period. During this period, growth of these tumors was demonstrated. These lesions were reported histologically to be drusen. The existence of presumed optic disc drusen in siblings with Usher syndrome m...

journal_title：Japanese journal of ophthalmology

authors： Shiono T,Noro M,Tamai M

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To examine the effects of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy (BK). STUDY DESIGN:Retrospective case series METHODS: Consecutive patients with BK who did not wish to receive corneal transplantation and were treated with 0.1% betamethasone eyedrops were incl...

journal_title：Japanese journal of ophthalmology

authors： Ono T,Iwasaki T,Yukawa C,Mori Y,Nejima R,Tokunaga T,Amano S,Miyata K

更新日期：2019-05-01 00:00:00

abstract：:Severe, white sheathing of the retinal vessels and yellowish-white placoid lesions, suggesting frosted-branch angiitis, were found in both fundi of a 24-year-old woman. Fluorescein angiography showed hypofluorescence of the placoid lesions in the early phase and hyperfluorescence in the late phase. Indocyanine green a...

journal_title：Japanese journal of ophthalmology

authors： Masuda K,Ueno M,Watanabe I

更新日期：1998-11-01 00:00:00

abstract：:To investigate the true structural changes in retinal cotton wool spots, serial sections of several blocks of retinal corresponding to cotton wool spots obtained from two hypertensive cases were studied by light and electron microscopy. Occlusion of the feeder arteriole and capillaries, and numerous vacuoles of variou...

journal_title：Japanese journal of ophthalmology

authors： Murata M,Yoshimoto H

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To explore methods of automated visual field (VF) examination for the assessment of macular function. METHOD:We used a VF examination (AP-7000 automatic perimeter, Kowa, Japan) to examine macular function in 53 eyes from 29 patients with open angle glaucoma. We measured the mean total deviation (c-MD) of 16 po...

journal_title：Japanese journal of ophthalmology

authors： Omodaka K,Kunimatsu-Sanuki S,Morin R,Tsuda S,Yokoyama Y,Takahashi H,Maruyama K,Kunikata H,Nakazawa T

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:To evaluate the functional surgical success, complications, and degree of satisfaction after endoscopy-guided transcaruncular Jones tube intubation without dacryocystorhinostomy (DCR). METHODS:A pair of Westcott scissors was passed into the nose from the side of the caruncle, and the lacrimal bone was penetrat...

journal_title：Japanese journal of ophthalmology

authors： Choi WC,Yang SW

更新日期：2006-03-01 00:00:00