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Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized controlled trial.

Abstract：

PURPOSE:Novel spectacle lenses (MyoVision, Carl Zeiss) designed to reduce relative peripheral hyperopia have been developed and reported to be effective for preventing myopia progression in a subgroup of Chinese children. In this study we examined the efficacy of MyoVision lenses in Japanese children. STUDY DESIGN:This was a multicenter prospective randomized double-blind placebo-controlled trial. METHOD:We enrolled 207 participants (aged 6-12 years) with spherical equivalent refractions (SERs) ranging from -1.5 to -4.5 diopters (D) and with at least 1 myopic parent. The participants were randomized to receive either single vision lenses (SVLs) or MyoVision lenses and were followed up every 6 months for 2 years. The primary outcome was myopia progression evaluated by cycloplegic autorefraction, and the secondary outcome was elongation of axial length. RESULTS:A total of 203 children (98.1%) completed the follow-up. The mean adjusted change in SER was -1.43 ± 0.10 D in the MyoVision group, which was not significantly different from that of the control group wearing SVLs (-1.39 ± 0.07 D) at the 24-month visit (P = .65). The adjusted axial length elongation was 0.73 ± 0.04 mm in the MyoVision group, which was not significantly different from that in the control group wearing SVLs (0.69 ± 0.03 mm) at the 24-month visit (P = .28). CONCLUSION:The results of this clinical trial could not verify the therapeutic effect of MyoVision for slowing down myopia progression in Japanese children. Additional studies are needed to design lenses that can reduce peripheral hyperopic defocus individually and to examine the effectiveness of these lenses in preventing myopia progression.

journal_name

Jpn J Ophthalmol

journal_title

Japanese journal of ophthalmology

authors

Kanda H,Oshika T,Hiraoka T,Hasebe S,Ohno-Matsui K,Ishiko S,Hieda O,Torii H,Varnas SR,Fujikado T

doi

10.1007/s10384-018-0616-3

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

537-543

issue

eissn

0021-5155

issn

1613-2246

pii

10.1007/s10384-018-0616-3

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized controlled trial.