Effects of intraocular pressure change on movement of FITC-dextran across vitreous-aqueous interface.

Abstract:

:In an attempt to study the effect of change in the intraocular pressure (IOP) on the status of the vitreous-aqueous interface, the effect of topical bunazosin was studied in the rabbit eye using the new Johnson-Maurice method. This entails an intravitreal injection of FITC-dextran and measurements of its concentration changes in the anterior chamber many days after the injection. Repeated instillations of bunazosin solution reduced the IOP by about 5 mmHg, without changing the aqueous flow rate as determined by the method of fluorometry. On the other hand, the FITC-dextran concentration in the anterior chamber increased, indicating that the movement of FITC-dextran from the vitreous into the aqueous was greater when the IOP was lowered. This increase in the FITC-dextran movement into the anterior chamber was thought to be mainly attributable to an increase in the anteriorly directed fluid movement across the vitreous-aqueous interface. The increase in the fluid movement was estimated to be about 1.3 microliter/hour. This study suggested that a reduction in the IOP generated a small fluid flow from the vitreous into the aqueous, and that the new Johnson-Maurice method can be a useful means for noninvasive investigations of the physiology of the vitreous-aqueous interface.

journal_name

Jpn J Ophthalmol

authors

Sugiura Y,Araie M

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

441-50

issue

4

eissn

0021-5155

issn

1613-2246

journal_volume

33

pub_type

杂志文章
  • Eye wall resection in the management of uveal neoplasms.

    abstract::Management of intraocular tumors, specifically uveal melanoma, is a matter of controversy. The treatment of these ocular neoplasms varies from observation to enucleation, irradiation (cobalt plaque and proton-helium particle) and eye wall resection. Over the last 18 years, we have developed two techniques for surgical...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Peyman GA,Gremillion CM

    更新日期:1989-01-01 00:00:00

  • Orbital exenteration after transarterial embolization in a patient with Wyburn-Mason syndrome: pathological findings.

    abstract:BACKGROUND:We present the pathological findings at orbital exenteration in a patient with Wyburn-Mason syndrome who underwent transarterial embolization. CASE:A 31-year-old man with a 10-year history of gradual exacerbation of left exophthalmos and left cheek swelling was found to have facial and orbital arteriovenous...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-008-0563-5

    authors: Matsuo T,Yanai H,Sugiu K,Tominaga S,Kimata Y

    更新日期:2008-07-01 00:00:00

  • Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion.

    abstract:PURPOSE:The involvement of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO). In this study, the concentrations of cytokines and chemokines in the vitreous fluid of eyes with DR and CRVO were measured and com...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-011-0004-8

    authors: Suzuki Y,Nakazawa M,Suzuki K,Yamazaki H,Miyagawa Y

    更新日期:2011-05-01 00:00:00

  • A case of frosted branch angiitis with yellowish-white placoid lesions: fluorescein and indocyanine green angiography findings.

    abstract::Severe, white sheathing of the retinal vessels and yellowish-white placoid lesions, suggesting frosted-branch angiitis, were found in both fundi of a 24-year-old woman. Fluorescein angiography showed hypofluorescence of the placoid lesions in the early phase and hyperfluorescence in the late phase. Indocyanine green a...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(98)00045-8

    authors: Masuda K,Ueno M,Watanabe I

    更新日期:1998-11-01 00:00:00

  • Effect of 3,3'-iminodipropionitrile on experimental intravitreal proliferation in albino rabbits.

    abstract::The effect of 3,3'-iminodipropionitrile (IDPN) on experimental intravitreal proliferation in albino rabbits was studied by light and electron microscopy. About 2.5 x 10(5) tissue cultured fibroblasts were injected into the vitreous cavity of albino rabbits. Immediately after the injection, phosphate-buffered solution ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Akiyama K

    更新日期:1990-01-01 00:00:00

  • Usefulness of anterior chamber depth measurement for efficacy assessment of steroid pulse therapy in patients with Vogt-Koyanagi-Harada disease.

    abstract:PURPOSE:To clarify the usefulness of measuring anterior chamber depth by the IOLMaster for early-stage assessment of the therapeutic effect of steroid pulse therapy in patients with Vogt-Koyanagi-Harada (VKH) syndrome with active uveitis. METHODS:Seven patients with VKH syndrome (three men and four women) participated...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-010-0843-8

    authors: Otsuki T,Shimizu K,Igarashi A,Kamiya K

    更新日期:2010-09-01 00:00:00

  • Patterns of glaucoma progression in retinal nerve fiber and macular ganglion cell-inner plexiform layer in spectral-domain optical coherence tomography.

    abstract:PURPOSE:To evaluate the progressive changes of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma. METHODS:One hundred-fourteen eyes of open-angle glaucoma p...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-017-0511-3

    authors: Kim HJ,Jeoung JW,Yoo BW,Kim HC,Park KH

    更新日期:2017-07-01 00:00:00

  • Optic disk drusen with central retinal artery occlusion.

    abstract::An 18-year-old Japanese boy with optic disk drusen associated with left central retinal artery occlusion was reported. Transient central blurred vision, possibly caused by central retinal artery spasm, was noticed as an initial symptom of optic disk drusen in the left eye. Prolonged and repeated spasm might have given...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Uehara M,Inomata H,Yamana Y,Taniguchi Y,Tsuji K

    更新日期:1982-01-01 00:00:00

  • Ultrastructural pleomorphism in medulloepithelioma of the ciliary body: a comparative study of tumour cells and fetal ciliary epithelium.

    abstract::A locally aggressive nonteratoid intraocular medulloepithelioma occurring in a two-year-old boy was studied by electron microscopy. For comparison the primitive pars plana region was examined in human fetal eyes obtained at 16, 18 and 22 weeks of gestation. The tumour was polymorphic with neural, intermediate and epit...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Wakakura M,Lee WR

    更新日期:1990-01-01 00:00:00

  • Movement of fluorescein and fluorescein glucuronide across the isolated rabbit iris-ciliary body.

    abstract::Movement of fluorescein and fluorescein glucuronide, a fluorescent metabolite of fluorescein, across the isolated iris-ciliary body of the albino rabbit was determined under short-circuit conditions using a modified Ussing's chamber. The permeabilities of this tissue to these dyes were calculated. The outward permeabi...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Eguchi S,Araie M,Takase M

    更新日期:1987-01-01 00:00:00

  • Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy.

    abstract:PURPOSE:To examine the effects of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy (BK). STUDY DESIGN:Retrospective case series METHODS: Consecutive patients with BK who did not wish to receive corneal transplantation and were treated with 0.1% betamethasone eyedrops were incl...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-019-00658-7

    authors: Ono T,Iwasaki T,Yukawa C,Mori Y,Nejima R,Tokunaga T,Amano S,Miyata K

    更新日期:2019-05-01 00:00:00

  • A new method for quantification of metamorphopsia in patients with epiretinal membrane

    abstract::Purpose: We have developed a new method for quantification of metamorphopsia and applied it to study distorted vision resulting from epiretinal membrane (ERM).Patients and Methods: We prepared a modified Amsler chart, which was a square grid formed by black lines on a white background with 12 cm on a side and divided ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(00)00157-x

    authors: Shinoda K,Ishida S,Kawashima S,Matsuzaki T,Yamada K,Katsura H

    更新日期:2000-05-01 00:00:00

  • Suppressive effect of aqueous humor on lipopolysaccharide-induced dendritic cell maturation.

    abstract:PURPOSE:The aqueous humor (AH) contains numerous immunosuppressive molecules that contribute to the ocular immune privilege. Here, we mimic an inflammatory environment to analyze the inhibitory effects of the AH on lipopolysaccharide (LPS)-induced maturation of dendritic cells (DC). METHODS:Different concentrations of...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-011-0060-0

    authors: Wang HF,Liu JL,Jiang XL,Lu JM,Li XL,Song XJ

    更新日期:2011-09-01 00:00:00

  • Concentric division of 10° visual field tests in retinitis pigmentosa.

    abstract:PURPOSE:The purpose of this study was to estimate the optimal size of visual field test for detecting longitudinal changes in retinitis pigmentosa (RP) by dividing the visual field. METHODS:We reviewed the results of 10° static visual field tests in 19 eyes of 19 RP patients. Sixty-eight numeric value points were divi...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-013-0235-y

    authors: Ogino K,Otani A,Oishi A,Kurimoto M,Sekiya T,Yoshimura N

    更新日期:2013-05-01 00:00:00

  • Pharmacological dissection of multifocal electroretinograms of rabbits with Pro347Leu rhodopsin mutation.

    abstract:PURPOSE:To determine whether photoreceptor degeneration in transgenic (Tg) rabbits carrying the Pro347Leu rhodopsin mutation alters the neural activity of the middle and inner retinal neurons. METHODS:Multifocal electroretinograms (mfERGs) were recorded from eight 12-week-old Tg rabbits both before and after intravitr...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-010-0842-9

    authors: Yokoyama D,Machida S,Kondo M,Terasaki H,Nishimura T,Kurosaka D

    更新日期:2010-09-01 00:00:00

  • Effects and distribution of intravitreally or subretinally injected silicone oil identified in rabbit retina using osmium tetroxide method.

    abstract::Silicone oil was injected into the eyes of 28 rabbits. Utilizing the specific affinity of osmium tetroxide for lipids, the pathological features and histochemical localization of silicone oil within the retina were studied. This osmium tetroxide technique makes it possible to identify the presence of silicone oil part...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Shikishima K,Ohki K,Machi N,Sano Y

    更新日期:1992-01-01 00:00:00

  • Analysis of macular curvature in normal eyes using swept-source optical coherence tomography.

    abstract:PURPOSE:To evaluate macular shape in normal eyes using swept-source optical coherence tomography (SS-OCT). STUDY DESIGN:Retrospective cross-sectional study. METHODS:We retrospectively evaluated 77 normal eyes of 48 subjects. Curvature of retinal pitment epithelium (RPE) and choroid/scleral interface (CSI) was measure...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-020-00721-8

    authors: Minami S,Ito Y,Ueno S,Kataoka K,Takeuchi J,Ito H,Nakano Y,Kitagawa M,Leahy C,Straub J,Terasaki H

    更新日期:2020-03-01 00:00:00

  • Functional visual field of patients with visual field loss.

    abstract::To assess the capability of perceiving forms in patients with visual field loss, a concept of functional visual field was introduced based on determinations of the time required for pattern recognition. Two series of stimulus patterns were made of Japanese syllabic hiragana characters drawn with black dots in the back...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Ikeda F,Ikeda M,Shioiri S,Takao M

    更新日期:1985-01-01 00:00:00

  • Nondetectable cone and rod electroretinographic responses in a patient with Cockayne syndrome.

    abstract::A 10-year-old girl complained or poor vision in both eyes. The patient showed progeria, physical and mental retardation, sensorineural hearing loss, cutaneous photosensitivity, hyperopia, poor pupillary dilation, exotropia, salt-and-pepper fundi, nondetectable cone and rod electroretinographic (ERG) responses, cerebra...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Ikeda N,Yamamoto S,Hayasaka S,Fukuo Y,Koike T

    更新日期:1995-01-01 00:00:00

  • Mathematical function describing visual gain curves following vitrectomy for different macular diseases.

    abstract:PURPOSE:To determine whether the time course of average visual recovery (visual gain curve) after vitrectomy for different macular diseases can be described by a mathematical function. METHODS:The medical records of 1951 eyes that underwent vitrectomy for different macular diseases such as macular hole, epiretinal mem...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-010-0922-x

    authors: Kumagai K,Ogino N,Larson E

    更新日期:2011-03-01 00:00:00

  • Morphological observations of rat corneal endothelial cells after exposure to ozonated solution.

    abstract:PURPOSE:To determine whether exposure to ozonated solution alters the morphology of corneal endothelial cells in rats and to examine the protective effect of ascorbic acid. METHODS:The anterior chambers of rat eyes were filled with 4 ppm of ozonated solution. Some were left in that state, while others were flushed out...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-008-0629-4

    authors: Suzuki H,Sato S,Murano N,Matsui H,Oharazawa H,Takahashi H

    更新日期:2009-03-01 00:00:00

  • Influence of sulfhydryl agents on cytoskeleton in cultured human trabecular cells.

    abstract::The effects of three sulfhydryl agents on the cytoskeletal systems of cultured human trabecular cells were examined by the immunofluorescence method. Incubation with iodoacetamide or N-ethyl maleimide (10(-6) M, 10(-5) M, and 10(-4) M) caused a marked alteration on the actin and microtubule organization, but had littl...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Iwamoto Y,Tamura M,Nakatsuka K,Yamanouchi U

    更新日期:1989-01-01 00:00:00

  • Immunogenetics of uveitis in leprosy.

    abstract:PURPOSE:To identify any possible determinants in the development of uveitis in leprosy patients. METHODS:Human leukocyte antigen (HLA) class I and II antigen, and HLA class II genotypings were analyzed among Japanese leprosy patients. Ninety-three unrelated Japanese leprosy patients (46 patients with a history of uvei...

    journal_title:Japanese journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0021-5155(98)00068-9

    authors: Joko S,Numaga J,Maeda H

    更新日期:1999-03-01 00:00:00

  • 2',3'-cyclic nucleotide 3'-phosphohydrolase activity in rat visual pathways with experimental allergic encephalomyelitis.

    abstract::The enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase) is one of the important markers for myelin synthesis or demyelination. We measured the CNPase activities in the visual pathway tissues of Lewis strain rats with experimental allergic encephalomyelitis (EAE) induced by inoculation of myelin basic protein f...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Matsushima S,Machi N,Marumo M,Mizuno A

    更新日期:1986-01-01 00:00:00

  • Effect of tannin on oxidative damage of ocular lens.

    abstract::The protective effect of geraniin (tannin from Geranium thunbergii) against oxidative damage was examined in the mouse ocular lens. Oxidative damage in the lens was induced by diamide, diazene dicarboxylic acid bis (N,N-dimethylamide); diamide oxidized the sulfhydryl groups in both the membrane and cytoplasm but did n...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Fukaya Y,Nakazawa K,Okuda T,Iwata S

    更新日期:1988-01-01 00:00:00

  • Fluorophotometry with a small animal adapter.

    abstract::The usefulness of the Fluorotron Master fluorophotometer fitted with a small animal adapter was evaluated with tree shrews. We also determined that the optimal measurement parameters for these animals, which are regarded as promising for experimental use in ophthalmic research, are: fluorescein-Na concentration, 0.5 x...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Ishiko S,Yoshida A,Kitaya N,Abiko T,Mori F,Kado M,Takahashi M,Saito K

    更新日期:1996-01-01 00:00:00

  • Retinoblastoma in Taiwan: survival rate and prognostic factors.

    abstract:PURPOSE:The mortality rate of patients with retinoblastoma still varies in developing countries, and data for Asia and Taiwan are relatively scarce. In this retrospective study, we aimed to describe the survival characteristics and prognostic factors of 54 retinoblastoma cases diagnosed at the Taipei Veterans General H...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-005-0320-y

    authors: Chang CY,Chiou TJ,Hwang B,Bai LY,Hsu WM,Hsieh YL

    更新日期:2006-05-01 00:00:00

  • Lens epithelial cells in postoperative aqueous humor.

    abstract::The aqueous humor during or after cataract surgery often contains red blood cells (RBCs) from blood; inflammatory cells from white blood cells (WBCs); fibrin, pigment cells, and fibroblasts from either the iris or the ciliary body; lens epithelial cells (LECs); and corneal endothelial cells. Since LECs may be related ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(96)00011-1

    authors: Majima K

    更新日期:1997-01-01 00:00:00

  • Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue.

    abstract:BACKGROUND:Epidermal nevus syndrome encompasses a group of congenital neurocutaneous anomalies characterized by epidermal nevi in association with cerebral, ocular, and skeletal abnormalities. We report herein the case of a Japanese girl with epidermal nevus syndrome associated with complex ocular choristoma and discus...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-009-0760-x

    authors: Miyagawa Y,Nakazawa M,Kudoh T

    更新日期:2010-01-01 00:00:00

  • Membrane-bound carbonic anhydrase activity in the rat corneal endothelium and retina.

    abstract::Localization of carbonic anhydrase (CA) was investigated in the rat eye by light and electron microscopy, and the inhibitory effects on CA distribution in the rat eye were compared between dorzolamide and acetazolamide. The cobalt sulfide histochemical method was used to study the CA localization. Acidic osmification ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Terashima H,Suzuki K,Kato K,Sugai N

    更新日期:1996-01-01 00:00:00