Alterations in ultrastructure and c-met expression in a case of ocular epithelial dysplasia following topical mitomycin C treatment.

abstract：PURPOSE:To evaluate the effects of topical latanoprost and timolol in combined therapy on retinal blood flow and tissue circulation in the optic nerve head (ONH) of the cynomolgus monkey. METHODS:Latanoprost (30 microL, 0.005%) was instilled once daily and timolol (30 microL, 0.5%) twice daily for 6 days into 1 eye, a...

journal_title：Japanese journal of ophthalmology

authors： Ishii K,Araie M

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To report three types of heterozygous mutations in the OPA1 gene in five patients from three families with autosomal dominant optic atrophy (ADOA, MIM#165500). METHODS:DNA was extracted from the leukocytes of the peripheral blood. For mtDNA, mutations were examined at positions 11778, 3460 and 14484. For the O...

journal_title：Japanese journal of ophthalmology

authors： Hamahata T,Fujimaki T,Fujiki K,Miyazaki A,Mizota A,Murakami A

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:We report here a patient with bilateral papillomacular retinoschisis with an enlarged glaucomatous optic nerve head cup and a focal lamina cribrosa defect, the findings of our clinical investigations of this case, and the chosen treatment and outcome. DESIGN:This is an observational case report. METHODS:Clini...

journal_title：Japanese journal of ophthalmology

authors： Yoshitake T,Nakanishi H,Setoguchi Y,Kuroda K,Amemiya K,Taniguchi M,Otani A

更新日期：2014-09-01 00:00:00

abstract：:Movement of fluorescein and fluorescein glucuronide, a fluorescent metabolite of fluorescein, across the isolated iris-ciliary body of the albino rabbit was determined under short-circuit conditions using a modified Ussing's chamber. The permeabilities of this tissue to these dyes were calculated. The outward permeabi...

journal_title：Japanese journal of ophthalmology

authors： Eguchi S,Araie M,Takase M

更新日期：1987-01-01 00:00:00

abstract：:Full-field electroretinograms (ERGs) provide a basis for establishing the diagnosis of widespread progressive forms of retinitis pigmentosa in early life even at a time when fundus abnormalities visible with the ophthalmoscope are minimal or absent. Patients characteristically show delays in rod or cone b-wave implici...

journal_title：Japanese journal of ophthalmology

authors： Berson EL

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:We evaluated central retinal thickness (CRT) in diabetic macular edema (DME) using two different spectral-domain (SD) optical coherence tomography (OCT) instruments: the Cirrus and Spectralis OCTs. METHODS:CRT was measured in 63 eyes of 32 patients with DME using both instruments on the same day. RESULTS:CRT ...

journal_title：Japanese journal of ophthalmology

authors： Suzuma K,Yamada Y,Liu M,Tsuiki E,Fujikawa A,Kitaoka T

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:This study examines the impact of cataracts on health-related quality of life (HR-QOL) and health events in the older population. METHODS:The study population consisted of 439 unoperated cataract patients aged 60 years or older who visited any of the facilities affiliated with the Cataract Survey Group of the ...

journal_title：Japanese journal of ophthalmology

authors： Yamada M,Mizuno Y,Miyake Y,Cataract Survey Group of the National Hospital Organization of Japan.

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:We have found that two aspartyl (Asp-151 and Asp-58) residues of alphaA-crystallin are inverted and isomerized to the biologically uncommon D-beta-Asp residues during aging. In order to elucidate the correlation between the formation of the D-beta-Asp isomer and the environment surrounding the Asp in the protei...

journal_title：Japanese journal of ophthalmology

authors： Mizuno A,Fujii N,Akaboshi M,Momose Y,Shimo-oka T

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To describe the characteristics and clinical course of patients with active posterior syphilitic uveitis evaluated between 1991 and 2009. METHODS:Retrospective chart review. RESULTS:Thirteen patients with active posterior syphilitic uveitis were identified at a single institution. All were men, and all with a...

journal_title：Japanese journal of ophthalmology

authors： Li SY,Birnbaum AD,Tessler HH,Goldstein DA

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To investigate mutations of causal genes in two affected male siblings of a Japanese family with suspected Leber congenital amaurosis (LCA) and to characterize the related clinical features. METHODS:After obtaining informed consent, genomic DNA was extracted from peripheral blood of the proband and his family ...

journal_title：Japanese journal of ophthalmology

authors： Suzuki T,Fujimaki T,Yanagawa A,Arai E,Fujiki K,Wada Y,Murakami A

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:We retrospectively investigated the efficacy of corneal crosslinking (CXL) on progressive keratoconus in a Japanese population and compared the outcomes of conventional and accelerated CXL. STUDY DESIGN:A retrospective cohort study METHODS: A total of 108 consecutive eyes in 95 patients (75 men; 21.9 ± 6.2 yea...

journal_title：Japanese journal of ophthalmology

authors： Kato N,Konomi K,Shinzawa M,Kasai K,Ide T,Toda I,Sakai C,Negishi K,Tsubota K,Shimazaki J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To investigate the frequency of infraorbital nerve enlargement (IONE) in orbital lymphoproliferative disorders, and to show that IONE can contribute to the clinical diagnosis of IgG4-related orbital diseases (IgG4-ROD). SUBJECTS AND METHODS:71 cases in which orbital lymphoproliferative disorders were diagnosed...

journal_title：Japanese journal of ophthalmology

authors： Ohshima K,Sogabe Y,Sato Y

更新日期：2012-07-01 00:00:00

abstract：:The protective effect of geraniin (tannin from Geranium thunbergii) against oxidative damage was examined in the mouse ocular lens. Oxidative damage in the lens was induced by diamide, diazene dicarboxylic acid bis (N,N-dimethylamide); diamide oxidized the sulfhydryl groups in both the membrane and cytoplasm but did n...

journal_title：Japanese journal of ophthalmology

authors： Fukaya Y,Nakazawa K,Okuda T,Iwata S

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To examine the effectiveness, safety, and stability of laser subepithelial keratomileusis (LASEK), a modified photorefractive keratectomy for low to moderate myopia. METHODS:This study evaluated the results of LASEK in 48 myopic patients (84 eyes) with a consecutive 6-month follow-up period. Preoperative myopi...

journal_title：Japanese journal of ophthalmology

authors： Lee JB,Choe CM,Seong GJ,Gong HY,Kim EK

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:To clarify the neuronal mechanism for the square-wave jerks (SWJs). METHODS:A 66-year-old man presented with oscillatory eye movements. He showed horizontal nystagmus in rightward gaze and SWJs during fixation at straight ahead. We recorded his eye movements with search coil methods and quantitatively analyzed...

journal_title：Japanese journal of ophthalmology

authors： Suzuki Y,Kase M,Hashimoto M,Ohtsuka K

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Novel spectacle lenses (MyoVision, Carl Zeiss) designed to reduce relative peripheral hyperopia have been developed and reported to be effective for preventing myopia progression in a subgroup of Chinese children. In this study we examined the efficacy of MyoVision lenses in Japanese children. STUDY DESIGN:Thi...

journal_title：Japanese journal of ophthalmology

authors： Kanda H,Oshika T,Hiraoka T,Hasebe S,Ohno-Matsui K,Ishiko S,Hieda O,Torii H,Varnas SR,Fujikado T

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To verify, by use of data collected by the Japan Glaucoma Society Survey of Bleb-related Infection (JGSSBI), that bleb morphology changes within 12 months of the development of bleb-related infection. METHODS:JGSSBI data from 57 eyes of 57 patients with primary open-angle glaucoma and normal tension glaucoma w...

journal_title：Japanese journal of ophthalmology

authors： Sawada A,Kuwayama Y,Yamamoto T

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To assess whether the outcomes of toric intraocular lens (IOL) implantation in eyes with oblique astigmatism can be improved by direct measurements of posterior corneal astigmatism using anterior segment optical coherence tomography (AS-OCT) instead of by using anterior corneal measurements alone. STUDY DESIGN...

journal_title：Japanese journal of ophthalmology

authors： Nakano S,Iida M,Hasegawa Y,Hiraoka T,Oshika T

更新日期：2021-01-28 00:00:00

abstract：PURPOSE:It is well-known that patients with psychogenic visual disturbances (PVD) exhibit characteristic kinetic visual fields. Even when the kinetic fields are normalized, the static fields of PVD children frequently remain abnormal. To verify this finding, we performed static perimetry on those children whose kinetic...

journal_title：Japanese journal of ophthalmology

authors： Osako M,Harasawa K,Suzuki H,Usui M,Hoshika A

更新日期：2000-09-01 00:00:00

abstract：:Severe, white sheathing of the retinal vessels and yellowish-white placoid lesions, suggesting frosted-branch angiitis, were found in both fundi of a 24-year-old woman. Fluorescein angiography showed hypofluorescence of the placoid lesions in the early phase and hyperfluorescence in the late phase. Indocyanine green a...

journal_title：Japanese journal of ophthalmology

authors： Masuda K,Ueno M,Watanabe I

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To investigate the recovery of short-wavelength sensitivity in patients who had undergone successful reattachment of a rhegmatogenous retinal detachment with macular involvement. METHODS:Postoperative assessment of the visual acuity and the visual fields by standard achromatic automated perimetry (SAP), and sh...

journal_title：Japanese journal of ophthalmology

authors： Sakai T,Iida K,Tanaka Y,Kohzaki K,Kitahara K

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:A prospective study was conducted to compare the effectiveness, safety, and stability of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) for correction of low to moderate myopia. METHODS:Forty-five patients with a manifest refraction (PRK, -4.54 +/- 0.80; LASIK, -4.82 +/- 1.10) from ...

journal_title：Japanese journal of ophthalmology

authors： Lee JB,Kim JS,Choe C,Seong GJ,Kim EK

更新日期：2001-09-01 00:00:00

abstract：:Changes in the distribution pattern of chloride ions were studied in the embryonic chicken retinal pigment epithelium (RPE), chloride ions being deposited as silver chloride (AgCl) in the RPE and observed by electron microscope. Before the 7th day after fertilization, the chloride ions did not accumulate anywhere in t...

journal_title：Japanese journal of ophthalmology

authors： Yamashita H,Yamamoto T

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To evaluate the changes in aqueous flare in psoriasis patients and to identify the factors that influence the level of aqueous flare. METHODS:We examined the 68 eyes of 34 psoriasis patients and the 68 eyes of 34 healthy subjects with a laser flare-cell meter. Complete dermatologic and ophthalmic examinations ...

journal_title：Japanese journal of ophthalmology

authors： Okamoto F,Umebayasi Y,Ohtsuka F,Hommura S

更新日期：2001-03-01 00:00:00

abstract：:Ca movements in mechanical responses of the isolated sphincter and dilator muscles of the rabbit iris to some drugs were studied. D600, a Ca-blocker, was practically ineffective in doses which relax the vascular and intestinal smooth muscles, while other smooth muscle relaxants were effective on the iris muscles in th...

journal_title：Japanese journal of ophthalmology

authors： Takayanagi I,Kaneko M,Hisayama T

更新日期：1983-01-01 00:00:00

abstract：:The enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase) is one of the important markers for myelin synthesis or demyelination. We measured the CNPase activities in the visual pathway tissues of Lewis strain rats with experimental allergic encephalomyelitis (EAE) induced by inoculation of myelin basic protein f...

journal_title：Japanese journal of ophthalmology

authors： Matsushima S,Machi N,Marumo M,Mizuno A

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To identify the cross-sectional characteristics of filtering blebs associated with intraocular pressure (IOP) control at 1 year after trabeculectomy with a square scleral flap and a fornix-based conjunctival flap. METHODS:A retrospective consecutive case series study was conducted. Eighty-four eyes of 79 patie...

journal_title：Japanese journal of ophthalmology

authors： Narita A,Morizane Y,Miyake T,Seguchi J,Baba T,Shiraga F

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Remodeling of the extracellular matrix occurs in the lamina cribrosa in progressed glaucomatous optic nerve damage including disc cupping. We examined immunohistochemical changes in the transforming growth factor (TGF)-beta and platelet-derived growth factor (PDGF) in the optic nerve head in an experimentally i...

journal_title：Japanese journal of ophthalmology

authors： Fukuchi T,Ueda J,Hanyu T,Abe H,Sawaguchi S

更新日期：2001-11-01 00:00:00

abstract：:We studied family members of 9 patients with falciform retinal fold, and found a number of cases showing features of familial exudative vitreoretinopathy (FEVR) in the fundi. Retinal fold was also seen in the eye of a cousin of the propositus. Three cases with falciform retinal fold were bilateral and 7 cases were uni...

journal_title：Japanese journal of ophthalmology

authors： Nishimura M,Yamana T,Sugino M,Kohno T,Yamana Y,Minei M,Sanui H

更新日期：1983-01-01 00:00:00

abstract：:A locally aggressive nonteratoid intraocular medulloepithelioma occurring in a two-year-old boy was studied by electron microscopy. For comparison the primitive pars plana region was examined in human fetal eyes obtained at 16, 18 and 22 weeks of gestation. The tumour was polymorphic with neural, intermediate and epit...

journal_title：Japanese journal of ophthalmology

authors： Wakakura M,Lee WR

更新日期：1990-01-01 00:00:00