Bilateral papillomacular retinoschisis and macular detachment accompanied by focal lamina cribrosa defect in glaucomatous eyes.

abstract：PURPOSE:To establish human corneal stroma- and sclera-derived cells as models for studying diseases of the anterior segment of the eye. METHODS:Using a recombinant retrovirus system, we transfected human papilloma virus 16 E6 and E7 (HPV16 E6/E7) into human corneal stroma- and sclera-derived cells. The primary cells a...

journal_title：Japanese journal of ophthalmology

authors： Kashiwagi Y,Nishitsuka K,Namba H,Kamiryo M,Takamura H,Yamashita H

更新日期：2010-01-01 00:00:00

abstract：:An animal model was used to evaluate the influence of residual lens cortex on postoperative inflammation and cellular deposits on intraocular lenses (IOLs). Eighteen New Zealand white rabbits underwent bilateral endocapsular phacoemulsification with placement of a one-piece polymethylmethacrylate (PMMA) IOL in the cap...

journal_title：Japanese journal of ophthalmology

authors： Tamura M,Monson MC,Davis B,Mamalis N

更新日期：1991-01-01 00:00:00

abstract：:Changes in the distribution pattern of chloride ions were studied in the embryonic chicken retinal pigment epithelium (RPE), chloride ions being deposited as silver chloride (AgCl) in the RPE and observed by electron microscope. Before the 7th day after fertilization, the chloride ions did not accumulate anywhere in t...

journal_title：Japanese journal of ophthalmology

authors： Yamashita H,Yamamoto T

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:A new method for quantification of metamorphopsia was applied to study distorted vision in patients with epiretinal membrane. METHOD:Sixty-three patients with unilateral epiretinal membrane in the macula were examined. A modified Amsler chart (a grid of black lines on a white background measuring 12 x 12 cm wi...

journal_title：Japanese journal of ophthalmology

authors： Shinoda K,Ishida S,Kawashima S,Matsuzaki T,Yamada K,Katsura H

更新日期：2000-07-01 00:00:00

abstract：:A locally aggressive nonteratoid intraocular medulloepithelioma occurring in a two-year-old boy was studied by electron microscopy. For comparison the primitive pars plana region was examined in human fetal eyes obtained at 16, 18 and 22 weeks of gestation. The tumour was polymorphic with neural, intermediate and epit...

journal_title：Japanese journal of ophthalmology

authors： Wakakura M,Lee WR

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To examine using the folds of the retinal pigment epithelium (RPE) to diagnose Vogt-Koyanagi-Harada (VKH) disease. METHODS:Retrospective clinical review of 57 Japanese patients between July 2005 and April 2009. Optical coherence tomography (OCT), fundus photographs and fluorescein angiography (FA) were studi...

journal_title：Japanese journal of ophthalmology

authors： Kato Y,Yamamoto Y,Tabuchi H,Fukushima A

更新日期：2013-01-01 00:00:00

abstract：:Silicone oil was injected into the eyes of 28 rabbits. Utilizing the specific affinity of osmium tetroxide for lipids, the pathological features and histochemical localization of silicone oil within the retina were studied. This osmium tetroxide technique makes it possible to identify the presence of silicone oil part...

journal_title：Japanese journal of ophthalmology

authors： Shikishima K,Ohki K,Machi N,Sano Y

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The involvement of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO). In this study, the concentrations of cytokines and chemokines in the vitreous fluid of eyes with DR and CRVO were measured and com...

journal_title：Japanese journal of ophthalmology

authors： Suzuki Y,Nakazawa M,Suzuki K,Yamazaki H,Miyagawa Y

更新日期：2011-05-01 00:00:00

abstract：:The motoneurons innervating the musculus levator palpebrae superioris (LPS) of the monkey, the cat and the rabbit were studied using horseradish peroxidase (HRP). Furthermore, LPS motoneurons of the cat and rabbit were studied by the double-labeling method using two fluorescent dyes as retrograde neuronal tracers. Aft...

journal_title：Japanese journal of ophthalmology

authors： Hiramoto D,Sekiya H,Kojima Y,Mukuno K,Ishikawa S

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To evaluate the progressive changes of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma. METHODS:One hundred-fourteen eyes of open-angle glaucoma p...

journal_title：Japanese journal of ophthalmology

authors： Kim HJ,Jeoung JW,Yoo BW,Kim HC,Park KH

更新日期：2017-07-01 00:00:00

abstract：:The usefulness of the Fluorotron Master fluorophotometer fitted with a small animal adapter was evaluated with tree shrews. We also determined that the optimal measurement parameters for these animals, which are regarded as promising for experimental use in ophthalmic research, are: fluorescein-Na concentration, 0.5 x...

journal_title：Japanese journal of ophthalmology

authors： Ishiko S,Yoshida A,Kitaya N,Abiko T,Mori F,Kado M,Takahashi M,Saito K

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To report three types of heterozygous mutations in the OPA1 gene in five patients from three families with autosomal dominant optic atrophy (ADOA, MIM#165500). METHODS:DNA was extracted from the leukocytes of the peripheral blood. For mtDNA, mutations were examined at positions 11778, 3460 and 14484. For the O...

journal_title：Japanese journal of ophthalmology

authors： Hamahata T,Fujimaki T,Fujiki K,Miyazaki A,Mizota A,Murakami A

更新日期：2012-01-01 00:00:00

abstract：:Cell population and proportion of each component cell type in preretinal membranes formed after retinal detachment were studied by light microscopy (LM) and transmission electron microscopy (TEM). The preretinal membranes were surgically obtained from 20 proliferative vitreoretinopathy (PVR) and 7 macular pucker patie...

journal_title：Japanese journal of ophthalmology

authors： Yamashita H,Hori S,Masuda K

更新日期：1986-01-01 00:00:00

abstract：:Histochemical studies were carried out in the mouse on the changes and distribution patterns of glycosaminoglycan molecular species during the separation of the lens vesicle. To obtain embryos, pregnant mice of the Jcl:ICR strain were sacrificed on day 10.5 or 11 of pregnancy. Serial frontal sections were strained wit...

journal_title：Japanese journal of ophthalmology

authors： Mizuno S,Ikeda K,Hirabayashi Y

更新日期：1995-01-01 00:00:00

abstract：:Diabetic retinopathy is a frequent cause of visual impairment in working-age adults (≥ 30 years) and in Japan is most commonly observed in those aged 50-69 years. Diabetic macular edema (DME) is one of the main causes of vision disturbance in diabetic retinopathy, which is a clinically significant microvascular compli...

journal_title：Japanese journal of ophthalmology

authors： Terasaki H,Ogura Y,Kitano S,Sakamoto T,Murata T,Hirakata A,Ishibashi T

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To evaluate dye retention in the fundus after indocyanine green (ICG)-assisted internal limiting membrane peeling. METHODS:Ten eyes with stage 3 or 4 nondiabetic idiopathic macular hole (MH group) and six eyes with diffuse diabetic macular edema (DM group) were studied. The fundus was examined with 780-nm infr...

journal_title：Japanese journal of ophthalmology

authors： Ashikari M,Ozeki H,Tomida K,Sakurai E,Tamai K,Ogura Y

更新日期：2006-07-01 00:00:00

abstract：:It has been reported that keratocytes endocytose foreign particles both in vitro and in vivo, suggesting the active participation of keratocytes in corneal wound healing and host defense mechanism. To understand the cellular response and the fate of engulfed foreign particles, we investigated the changes in the lysoso...

journal_title：Japanese journal of ophthalmology

authors： Mishima H,Ueda A,Nishida T,Otori T

更新日期：1992-01-01 00:00:00

abstract：:We investigated the ocular fundus of (NZWXBXSB) F1 mice, which are considered to be a good model for systemic lupus erythematosus (SLE) with antiphospholipid syndrome. The abnormal fundus findings were documented by fundus photography, and the chorioretinal lesions were studied histopathologically. The incidence of oc...

journal_title：Japanese journal of ophthalmology

authors： Nakamura A,Yokoyama T,Kodera S,Zhang D,Hirose S,Shirai T,Kanai A

更新日期：1998-09-01 00:00:00

abstract：:Purpose: We previously reported that a unique free fluorophore (Fl-Glc), presumably a beta-glucoside, is particularly abundant in human brunescent cataractous lens nuclei. Our preliminary experiments indicated that incubation of low-molecular weight (MW) fraction of non-brunescent lens nuclei causes an increase in a p...

journal_title：Japanese journal of ophthalmology

authors： Ando K,Shirao E,Iwakuchi Y,Shirao Y,Inoue A

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Vogt-Koyanagi-Harada (VKH) disease patients with the complication of subretinal pigmented proliferative tissue tend to have a poor visual prognosis. CASE:We herein report a case of VKH with good visual acuity despite a prominent subretinal fold. OBSERVATIONS:A 24-year-old woman, who experienced several rec...

journal_title：Japanese journal of ophthalmology

authors： Noda Y,Sonoda KH,Nakamura T,Kawano YI,Ishibashi T,Inomata H

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:We present 6 cases of bacterial infection that developed after porous orbital implant surgery. CASES:Five patients with hydroxyapatite implants showed lid swelling, discharge, and suppurative granuloma 14 days to 3 years after surgery. The hydroxyapatite implants were removed 14 days to 41 months postoperat...

journal_title：Japanese journal of ophthalmology

authors： You JR,Seo JH,Kim YH,Choi WC

更新日期：2003-09-01 00:00:00

abstract：:A newly developed model of keratoepithelioplasty (KEP) in the rat was used to analyze the effect of anterior chamber-associated immune deviation on the suppression of corneal allograft rejection. The right eyes of Fisher rats received an anterior chamber (AC) injection of lymphocyte suspension from Dark Agouti (DA) ra...

journal_title：Japanese journal of ophthalmology

authors： Yao YF,Inoue Y,Hara Y,Kiritoshi A,Tano Y,Ohashi Y

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To assess the proportion of glaucomatous eyes based on the association between optic disc (OD) size and its clinical determinants in the resident population of Namil-myon, Central South Korea. METHODS:Of the 1,532 participants in the Namil study, we included 1,410 Koreans (2,734 eyes) with legible fundus photo...

journal_title：Japanese journal of ophthalmology

authors： Kang NH,Jun RM,Choi KR,Namil Study group, Korean Glaucoma Society.

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:To evaluate the effect of tetramethylpyrazine on the elevation of aqueous flare and intraocular pressure (IOP) induced by prostaglandin (PG) E(2) and PGE(2) receptor (EP) agonists. METHODS:PGE(2) or EP agonists (11-deoxy PGE(1), EP(2) agonist; 17-phenyl trinor PGE(2), EP(1) and EP(3) agonist; or sulprostone, E...

journal_title：Japanese journal of ophthalmology

authors： Kitagawa K,Hayasaka S,Nagaki Y,Watanabe K

更新日期：2001-05-01 00:00:00

abstract：:A computerized digital image analysis system was developed to evaluate the retinal nerve fiber layer (RNFL) by red-free fundus photography. The image intensity of the RNFL was computed for 30 degrees between the disc and macula. Thirty early open-angle glaucoma patients and 30 normal age-matched subjects were examined...

journal_title：Japanese journal of ophthalmology

authors： Yamazaki Y,Miyazawa T,Yamada H

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To evaluate the clinical significance of 5-S-cysteinyldopa (5-S-CD), a major intermediate in melanin synthesis, as a potential diagnostic tumor marker for uveal malignant melanoma. METHODS:The levels of 5-S-CD in the serum were measured by high-performance liquid chromatography in 16 patients with primary uvea...

journal_title：Japanese journal of ophthalmology

authors： Goto H,Usui M,Wakamatsu K,Ito S

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients. METHODS:Twenty-two eyes from 22 patients w...

journal_title：Japanese journal of ophthalmology

authors： Cho SY,Kim YY,Yoo C,Lee TE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To determine whether the single-flash electroretinogram (ERG) can predict the postoperative outcome in diabetic cases where massive vitreous hemorrhage precludes fundus observation. METHODS:Eighty-five diabetic patients (105 eyes) who underwent vitrectomy due to dense vitreous hemorrhage were studied retrospec...

journal_title：Japanese journal of ophthalmology

authors： Hiraiwa T,Horio N,Terasaki H,Suzuki T,Yamamoto E,Horiguchi M,Miyake Y

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Vogt-Koyanagi-Harada (VKH) disease is known to have varied manifestations in different ethnic groups. In order to analyze the clinical profile of VKH cases in the Indian population, we studied 87 consecutive cases of VKH disease treated in an uveitis clinic in South India between 1985 and 1996. METHODS:Retrosp...

journal_title：Japanese journal of ophthalmology

authors： Mondkar SV,Biswas J,Ganesh SK

更新日期：2000-05-01 00:00:00

abstract：:Regulation of fluid flow through corneal stroma was investigated in the bullfrog. Corneal specimens were mounted by clamping their limbal sclera between the two chambers of a Ussing-type chamber. The epithelial surface was covered with Ringer's solution, while the endothelial surface was superfused with Ringer's solut...

journal_title：Japanese journal of ophthalmology

authors： Kubota S,Kani K,Kitasato H

更新日期：1998-01-01 00:00:00