Mechanical responses and calcium movements in rabbit iris smooth muscles.

Abstract:

:Ca movements in mechanical responses of the isolated sphincter and dilator muscles of the rabbit iris to some drugs were studied. D600, a Ca-blocker, was practically ineffective in doses which relax the vascular and intestinal smooth muscles, while other smooth muscle relaxants were effective on the iris muscles in the same doses as used for other smooth muscles. The contractile responses of both iris smooth muscles to K+ and acetylcholine were immediately abolished by Ca removal from the bath fluid, suggesting that these contractile responses were due to Ca influx. Furthermore, Ca-channels studied seem to be uninfluenced by D600. A residual response to norepinephrine was observed in the iris dilator muscle immersed in the Ca-free solution and the contractile response of the skinned fiber of this muscle to norepinephrine was also obtained at a low Ca solution. Accordingly, contraction of the dilator muscle by norepinephrine seems to be due mainly to a facilitation of the release of intracellularly sequestered Ca.

journal_name

Jpn J Ophthalmol

authors

Takayanagi I,Kaneko M,Hisayama T

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

575-84

issue

4

eissn

0021-5155

issn

1613-2246

journal_volume

27

pub_type

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