Abstract:
:Ca movements in mechanical responses of the isolated sphincter and dilator muscles of the rabbit iris to some drugs were studied. D600, a Ca-blocker, was practically ineffective in doses which relax the vascular and intestinal smooth muscles, while other smooth muscle relaxants were effective on the iris muscles in the same doses as used for other smooth muscles. The contractile responses of both iris smooth muscles to K+ and acetylcholine were immediately abolished by Ca removal from the bath fluid, suggesting that these contractile responses were due to Ca influx. Furthermore, Ca-channels studied seem to be uninfluenced by D600. A residual response to norepinephrine was observed in the iris dilator muscle immersed in the Ca-free solution and the contractile response of the skinned fiber of this muscle to norepinephrine was also obtained at a low Ca solution. Accordingly, contraction of the dilator muscle by norepinephrine seems to be due mainly to a facilitation of the release of intracellularly sequestered Ca.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Takayanagi I,Kaneko M,Hisayama Tsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
575-84issue
4eissn
0021-5155issn
1613-2246journal_volume
27pub_type
杂志文章abstract:PURPOSE:The aim of this study was to experimentally investigate changes in visible light-induced photo-oxidation and to evaluate the inhibitory effect of various acrylic tinted intraocular lenses (IOLs) on photooxidation. METHODS:Three types of nontinted (VA-60BB, HOYA; SA60AT, Alcon; AU-6, Menicon) and tinted (YA-60B...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-008-0620-0
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To compare endothelial damage of the donor cornea in relation to the method of inserting the donor cornea into the recipient anterior chamber during Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:Fifteen enucleated pig eyes were used. The donor corneoscleral buttons were mounted in an a...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-009-0713-4
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To evaluate the effects of topical latanoprost and timolol in combined therapy on retinal blood flow and tissue circulation in the optic nerve head (ONH) of the cynomolgus monkey. METHODS:Latanoprost (30 microL, 0.005%) was instilled once daily and timolol (30 microL, 0.5%) twice daily for 6 days into 1 eye, a...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(99)00217-8
更新日期:2000-05-01 00:00:00
abstract:PURPOSE:To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients. METHODS:Twenty-two eyes from 22 patients w...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-015-0413-1
更新日期:2016-01-01 00:00:00
abstract::Severe, white sheathing of the retinal vessels and yellowish-white placoid lesions, suggesting frosted-branch angiitis, were found in both fundi of a 24-year-old woman. Fluorescein angiography showed hypofluorescence of the placoid lesions in the early phase and hyperfluorescence in the late phase. Indocyanine green a...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(98)00045-8
更新日期:1998-11-01 00:00:00
abstract::We assessed the function of Endothelin-1 (ET-1) in the development of anterior chamber inflammation in pigmented rabbit eyes. After the injection of ET-1 solution (10(-13), 10(-11), 10(-9), or 10(-7) M, diluted with 300 microL of artificial aqueous humor) into the anterior chamber, the aqueous protein concentration (A...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(97)00032-4
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:It is well-known that patients with psychogenic visual disturbances (PVD) exhibit characteristic kinetic visual fields. Even when the kinetic fields are normalized, the static fields of PVD children frequently remain abnormal. To verify this finding, we performed static perimetry on those children whose kinetic...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(00)00215-x
更新日期:2000-09-01 00:00:00
abstract:PURPOSE:To examine the correlation between the van Herick system and the Shaffer system in a large-scale epidemiological survey conducted on healthy Japanese subjects. METHODS:The van Herick technique was performed on 14,779 subjects aged 40 years and over who participated in an ophthalmic epidemiological survey condu...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-004-0169-5
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:To measure changes in choroidal thickness (CT), retinal thickness (RT), and axial length (AL) accompanying intraocular pressure (IOP) increase and to investigate the changes in axial eye dimensions induced by IOP increase. METHODS:Thirty-four eyes of 34 patients undergoing a diagnostic provocative test for pri...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-012-0173-0
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To clarify the redox states of the aqueous humor and serum in senile cataract patients. METHODS:We analyzed the reduced and oxidized albumin fractions in 58 patients. The patients had no detectable evidence of other eye or systemic diseases and were divided into two age groups (53-75 and 76-96 years). Analysis...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-010-0877-y
更新日期:2010-11-01 00:00:00
abstract::Fibronectin (FN) has been detected at the site of corneal wounds. To investigate whether FN is supplied by the cornea itself or by extracorneal sources, we cultured small blocks of rabbit cornea in vitro with and without autologous serum (5%). The sliding rate of epithelial cells was determined and localization of FN ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Hematoxylin-eosin staining, the TUNEL method for in situ detection of the intranuclear DNA fragmentation, which indicates apoptosis, and electron microscopy were used to study the morphologic changes in specimens from the eyes of 8 patients with secondary glaucoma and 2 normal control eyes to evaluate our hypothesis t...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(97)00013-0
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Although air bags have been shown to reduce the number of fatalities and serious injuries caused by motor vehicle accidents, there have been many reports of air bag-related ocular injuries. We recently treated air bag-related corneal laceration in a patient wearing eyeglasses at the time of a motor accident....
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(99)00007-6
更新日期:1999-05-01 00:00:00
abstract::Distribution of microglia cells was studied in the normal retina of Wistar rats kept in a specific-pathogen-free condition, using a combined technique of light and electron microscopy with the weak silver carbonate staining method of del Rio-Hortega. Typical microglia cells were found mainly in the inner plexiform lay...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To prospectively compare the scotopic pupil size between emmetropes and myopes using a Colvard pupillometer. METHODS:The pupil diameters of 55 normal subjects and 55 healthy myopic subjects were measured with the Colvard pupillometer in a low-light situation that simulated the level of light encountered while ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(02)00556-7
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To analyze mutations of the arrestin/S-antigen (SAG) gene in nine newly identified Oguchi disease patients, and to examine whether the 926delA (formerly called 1147delA) mutation in the SAG gene is inherited from a single founder. METHODS:DNA samples were assayed for mutations around nucleotide 926 of the SAG ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-004-0070-2
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:Remodeling of the extracellular matrix occurs in the lamina cribrosa in progressed glaucomatous optic nerve damage including disc cupping. We examined immunohistochemical changes in the transforming growth factor (TGF)-beta and platelet-derived growth factor (PDGF) in the optic nerve head in an experimentally i...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(01)00414-2
更新日期:2001-11-01 00:00:00
abstract::The aqueous humor during or after cataract surgery often contains red blood cells (RBCs) from blood; inflammatory cells from white blood cells (WBCs); fibrin, pigment cells, and fibroblasts from either the iris or the ciliary body; lens epithelial cells (LECs); and corneal endothelial cells. Since LECs may be related ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(96)00011-1
更新日期:1997-01-01 00:00:00
abstract::Using polymerase chain reaction, we detected the varicella-zoster virus genome in the vitreous humor of two patients with clinically diagnosed acute retinal necrosis. One of the two cases was thought to be caused by infection with a varicella-zoster virus lacking a PstI cleavage site. We could not find any clinical di...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(98)00005-7
更新日期:1998-05-01 00:00:00
abstract:PURPOSE:To elucidate the characterization of intraocular pressure (IOP) spike after trabeculotomy, and after the combined procedure of phacoemulsification and aspiration (PEA) and intraocular lens (IOL) implantation. METHODS:Included in this study were 39 patients (53 eyes) with primary open-angle glaucoma with IOPs u...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(01)00322-7
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:To evaluate the functional surgical success, complications, and degree of satisfaction after endoscopy-guided transcaruncular Jones tube intubation without dacryocystorhinostomy (DCR). METHODS:A pair of Westcott scissors was passed into the nose from the side of the caruncle, and the lacrimal bone was penetrat...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-005-0284-y
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:To determine the psychological state and personality traits of patients with retinitis pigmentosa (RP) or glaucoma so that a closer and better relationship can be developed with the patients. METHODS:The Yatabe-Guilford personality test was administered to 75 RP patients and 42 glaucoma patients. The latter gr...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(02)00621-4
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To investigate the recovery of short-wavelength sensitivity in patients who had undergone successful reattachment of a rhegmatogenous retinal detachment with macular involvement. METHODS:Postoperative assessment of the visual acuity and the visual fields by standard achromatic automated perimetry (SAP), and sh...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-005-0201-4
更新日期:2005-07-01 00:00:00
abstract::Glycosaminoglycans (GAG) in pterygium tissues were analyzed and the results were compared with those in the normal human conjunctiva. A marked difference in the GAG composition was found: 78% of the total hexosamines of GAG from pterygium was glucosamine, whereas 98% of those of the conjunctiva was galactosamine. Pter...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To compare the progression of posterior vitreous detachment (PVD) during aging among eyes of diabetics with diabetic retinopathy (DR), eyes of diabetics without DR, and eyes of nondiabetics. STUDY DESIGN:Prospective cross-sectional study. METHODS:One-hundred thirty-three diabetic eyes with DR (DR group), 254 ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-020-00720-9
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:We report a patient with a limited form of Wegener's granulomatosis (WG) who presented with ocular changes and an eyelid ulcer in her left eye. CASE:A 56-year-old woman complained of ocular pain and discharge. Upon examination, we found evidence of ulcerative keratitis, a mass in the orbit, and an eyelid sk...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(03)00078-9
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:We investigated the keratocyte response and stromal remodeling after corneal incision and photorefractive keratectomy to understand the histophysiological and immunohistochemical differences between these two types of surgery. METHODS:Corneal incision or photorefractive keratectomy was performed in rabbits or ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(00)00269-0
更新日期:2000-11-01 00:00:00
abstract::A 76-year-old Japanese woman had suffered from fatigue, weight loss, and cutaneous hyperpigmentation at the age of 38 years and was diagnosed as having tuberculous Addison's disease. Since then, corticosteroids had been administered effectively as hormonal replacement. At the age of 75 years, the patient presented wit...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(98)00024-0
更新日期:1998-09-01 00:00:00
abstract::Experimental melanin-protein induced uveitis (EMIU) is a CD4 T cell-mediated disease involving the choroid and iris, but sparing the retina. The present study was designed to solubilize uveitogenic antigen from melanin granules without enzymatic digestion, and to investigate some of its elements by comparison with dif...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The effect of 3,3'-iminodipropionitrile (IDPN) on experimental intravitreal proliferation in albino rabbits was studied by light and electron microscopy. About 2.5 x 10(5) tissue cultured fibroblasts were injected into the vitreous cavity of albino rabbits. Immediately after the injection, phosphate-buffered solution ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00