Leaky neural integration observed in square-wave jerks.

Abstract:

PURPOSE:To clarify the neuronal mechanism for the square-wave jerks (SWJs). METHODS:A 66-year-old man presented with oscillatory eye movements. He showed horizontal nystagmus in rightward gaze and SWJs during fixation at straight ahead. We recorded his eye movements with search coil methods and quantitatively analyzed them. RESULTS:Visually guided rightward saccades were followed by exponential drifts with average time constants of 0.3-1.0 second, indicating a leaky rightward velocity-to-position integrator. Amplitude of SWJs ranged from 0.5 to 2.5 degrees and average intersaccadic interval was 0.2 seconds. In addition, exponential drifts similar to those observed after visually guided saccades were observed in the SWJs. Rightward fast eye movements of SWJs were followed by exponential drifts lasting for 0.2 seconds with average time constant (+/-SD) of 0.7+/-0.3 seconds. CONCLUSIONS:Position signals after visually guided saccades and SWJs were outputs of the identical velocity-to-position integrator. SWJs are generated by the neural circuits involving a pulse generator and a velocity-to-position integrator.

journal_name

Jpn J Ophthalmol

authors

Suzuki Y,Kase M,Hashimoto M,Ohtsuka K

doi

10.1016/s0021-5155(03)00144-8

keywords:

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

535-6

issue

6

eissn

0021-5155

issn

1613-2246

pii

S0021515503001448

journal_volume

47

pub_type

杂志文章
  • Histopathological study of microspherophakia in the Weill-Marchesani syndrome.

    abstract::A surgically obtained lens from a 66-year-old man with the Weill-Marchesani syndrome was examined histopathologically by light microscopy, transmission electron microscopy and scanning electron microscopy. The lens was diffusely opaque and brown. It was microspherophakic in appearance, 6.0 mm in equatorial diameter an...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Nagata M,Takagi S,Yamasaki A,Tsunematsu S,Kumagami T,Itamochi C,Tamai A

    更新日期:1995-01-01 00:00:00

  • Changes in distribution of chloride ions in embryonic chicken retinal pigment epithelium.

    abstract::Changes in the distribution pattern of chloride ions were studied in the embryonic chicken retinal pigment epithelium (RPE), chloride ions being deposited as silver chloride (AgCl) in the RPE and observed by electron microscope. Before the 7th day after fertilization, the chloride ions did not accumulate anywhere in t...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Yamashita H,Yamamoto T

    更新日期:1990-01-01 00:00:00

  • Characteristics of successful filtering blebs at 1 year after trabeculectomy using swept-source three-dimensional anterior segment optical coherence tomography.

    abstract:PURPOSE:To identify the cross-sectional characteristics of filtering blebs associated with intraocular pressure (IOP) control at 1 year after trabeculectomy with a square scleral flap and a fornix-based conjunctival flap. METHODS:A retrospective consecutive case series study was conducted. Eighty-four eyes of 79 patie...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-017-0504-2

    authors: Narita A,Morizane Y,Miyake T,Seguchi J,Baba T,Shiraga F

    更新日期:2017-05-01 00:00:00

  • Tear film break-up time evaluated by real-time Hartmann-Shack wavefront sensing.

    abstract:PURPOSE:To develop a novel method for measuring tear break-up time (BUT) by continuously measuring higher order wavefront aberrations using a Hartmann-Shack (H-S) aberrometer. METHODS:Wavefront aberrations up to the sixth order for a 4-mm pupil were measured in six eyes of six normal subjects using an H-S aberrometer....

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-005-0289-6

    authors: Mihashi T,Hirohara Y,Koh S,Ninomiya S,Maeda N,Fujikado T

    更新日期:2006-03-01 00:00:00

  • Subclinical optic neuropathy in Graves' orbitopathy.

    abstract:PURPOSE:The aims of the study were to detect early changes in the optic nerve function of patients with Graves' orbitopathy (GrO) who do not have any signs and symptoms of optic neuropathy, using pattern visual evoked potentials (P-VEP), and investigate any possible relation between the disease activity and P-VEP P100 ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(03)00101-1

    authors: Acaroğlu G,Simşek T,Ozalp S,Mutluay A

    更新日期:2003-09-01 00:00:00

  • The relationship between visual disability and visual scores in patients with retinitis pigmentosa.

    abstract:PURPOSE:To evaluate the relationship between visual disability and visual scores in patients with retinitis pigmentosa. METHODS:The relationship between visual disability and visual scores (visual acuity and visual field) was investigated in 93 patients with retinitis pigmentosa. The visual disability of each patient ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(99)00171-9

    authors: Sumi I,Matsumoto S,Okajima O,Shirato S

    更新日期:2000-01-01 00:00:00

  • Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography.

    abstract:PURPOSE:To measure choroidal thickness in healthy pregnant women using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare the measurements with those of healthy non-pregnant women. METHODS:Choroidal thickness was measured at the fovea and at 3 mm superior, inferior, temporal, and nasal to the fo...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-013-0265-5

    authors: Takahashi J,Kado M,Mizumoto K,Igarashi S,Kojo T

    更新日期:2013-09-01 00:00:00

  • Spectral sensitivity of monochromatic ERG c-wave of chicken under color adaptation.

    abstract::The spectral sensitivity of the ERG c-wave was studied in the chicken under yellow or red light adaptation of various intensities, ie, 1, 3, 4 and 5 W/m2 at the corneal surface in the former, and 3, 4 and 5 W/m2 in the latter. The peak wavelength of the spectral sensitivity curve of the c-wave amplitude under both yel...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Takahashi K,Fukuda A,Mori T,Takahashi Y,Onoe S,Yoshimura Y,Tazawa Y

    更新日期:1993-01-01 00:00:00

  • Colvard pupillometer measurement of scotopic pupil diameter in emmetropes and myopes.

    abstract:PURPOSE:To prospectively compare the scotopic pupil size between emmetropes and myopes using a Colvard pupillometer. METHODS:The pupil diameters of 55 normal subjects and 55 healthy myopic subjects were measured with the Colvard pupillometer in a low-light situation that simulated the level of light encountered while ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(02)00556-7

    authors: Chaidaroon W,Juwattanasomran W

    更新日期:2002-11-01 00:00:00

  • In vivo effects of prostaglandins on human retinoblastoma cells in nude mice.

    abstract::Prostaglandin D2 (PGD2) and 64E, a derivative of PGs, were tested for their capacity to suppress the growth of retinoblastoma in the nude mouse. Ten million cells of an established cell line of human retinoblastoma, Y-79 cells, were transferred subcutaneously into the nude mouse, and after the transferred cells became...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Nakamura M,Fujino Y,Mochizuki M,Minoda K,Masuda K

    更新日期:1987-01-01 00:00:00

  • Histochemical studies of the separation of the lens vesicle in the mouse.

    abstract::Histochemical studies were carried out in the mouse on the changes and distribution patterns of glycosaminoglycan molecular species during the separation of the lens vesicle. To obtain embryos, pregnant mice of the Jcl:ICR strain were sacrificed on day 10.5 or 11 of pregnancy. Serial frontal sections were strained wit...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Mizuno S,Ikeda K,Hirabayashi Y

    更新日期:1995-01-01 00:00:00

  • Retinal glial cells stimulate microvascular pericyte proliferation via fibroblast growth factor and platelet-derived growth factor in vitro.

    abstract:PURPOSE:To investigate whether retinal glial cells (RGCs), which are believed to play an important role in the development and maintenance of microvessels, stimulate the proliferation of retinal bovine microvascular pericytes, an essential component of the vessels. METHODS:Conditioned medium (CM) was collected from a ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(02)00527-0

    authors: Ikuno Y,Hibino S,Bando H,Kawasaki Y,Nakamura T,Tano Y

    更新日期:2002-07-01 00:00:00

  • Electron microscopic observation of preretinal membranes.

    abstract::In this report, membranes removed during vitrectomy were observed by various methods of electron microscopy to determine their three-dimensional structure and the mechanism of the contraction of preretinal membranes. The vitreous side surface of the preretinal membranes was covered by two types of flat cells, cells wi...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Yamamoto T,Yamashita H,Hori S

    更新日期:1989-01-01 00:00:00

  • Utility values in Japanese patients with exudative age-related macular degeneration.

    abstract:PURPOSE:To investigate the utility values associated with visual loss due to age-related macular degeneration (AMD) in Japanese patients. METHODS:Utility values in 48 Japanese patients with bilateral exudative AMD were measured using the time trade-off and standard gamble methods. RESULTS:The time trade-off method ut...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-010-0893-y

    authors: Yanagi Y,Ueta T,Obata R,Iriyama A,Fukuda T,Hashimoto H

    更新日期:2011-01-01 00:00:00

  • Characteristics of the macular microvasculature.

    abstract::The morphological appearance and the quantitative analysis of the structure of the macular microvasculature were investigated in 33 normal subjects by fluorescein angiography and stereoscopic mapping techniques. The foveal capillary network was formed by the anastomosis of 4 to 6 groups of terminal arteriolar and veno...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Wu LZ,Huang ZS,Wu DZ,Chan E

    更新日期:1985-01-01 00:00:00

  • Bimatoprost 0.01 % for previously treated patients with open-angle glaucoma or ocular hypertension in the Korean clinical setting.

    abstract:PURPOSE:To evaluate the occurrence of hyperemia with, and efficacy of, bimatoprost 0.01 % for patients in Korea previously treated for open-angle glaucoma (OAG; including normal tension glaucoma) or ocular hypertension (OHT). METHODS:In this multicenter, observational study (Asia Pacific Patterns from Early Access of ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10384-015-0392-2

    authors: Kook MS,Simonyi S,Sohn YH,Kim CY,Park KH

    更新日期:2015-09-01 00:00:00

  • Influence of cyclosporin on steroid-induced cataracts after renal transplantation.

    abstract:PURPOSE:To study the effect of cyclosporin (CsA) on steroid-induced cataracts in patients following renal transplantation. METHODS:The subjects comprise 140 patients who had undergone renal transplantation at Kanazawa Medical Hospital. These subjects had received ophthalmologic examinations prior to their surgery and ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(03)00020-0

    authors: Nakamura T,Sasaki H,Nagai K,Fujisawa K,Sasaki K,Suzuki K,Tsugawa R

    更新日期:2003-05-01 00:00:00

  • A multicenter study of typical retinitis pigmentosa in Japan.

    abstract::A nationwide, multicenter study of typical retinitis pigmentosa was carried out in collaboration with 13 university hospitals throughout Japan. A total of 253 patients, 122 males and 131 females, with a wide range of ages (mean 48 years), were registered during a two-month period in 1989. Determination of inheritance ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Hayakawa M,Matsumura M,Ohba N,Matsui M,Fujiki K,Kanai A,Tamai M,Shiono T,Tokoro T,Akazawa Y

    更新日期:1993-01-01 00:00:00

  • Suppressive effect of aqueous humor on lipopolysaccharide-induced dendritic cell maturation.

    abstract:PURPOSE:The aqueous humor (AH) contains numerous immunosuppressive molecules that contribute to the ocular immune privilege. Here, we mimic an inflammatory environment to analyze the inhibitory effects of the AH on lipopolysaccharide (LPS)-induced maturation of dendritic cells (DC). METHODS:Different concentrations of...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-011-0060-0

    authors: Wang HF,Liu JL,Jiang XL,Lu JM,Li XL,Song XJ

    更新日期:2011-09-01 00:00:00

  • Core vitrectomy preceding triple corneal procedure in patients at high risk for increased posterior chamber pressure.

    abstract::We evaluated the effectiveness of performing a core vitrectomy to prevent intraoperative posterior chamber pressure evaluation in eyes at high risk for development of this complication, prior to penetrating keratoplasty, extracapsular cataract extraction and posterior chamber lens (IOL) implantation. Results in 10 cas...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(97)00046-4

    authors: Shimomura Y,Hosotani H,Kiritoshi A,Watanabe H,Tano Y

    更新日期:1997-07-01 00:00:00

  • Sicca syndrome and HTLV-I-associated myelopathy/tropical spastic paraparesis.

    abstract:PURPOSE:The objective of this study is to describe the clinical and immunological aspects observed in patients with both human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis and ocular dryness. METHODS:In 15 such patients, clinical and biological examinations completed with a biops...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(99)00106-9

    authors: Merle H,Cabre P,Smadja D,Josset P,Landau M,Vernant JC

    更新日期:1999-11-01 00:00:00

  • Glycosaminoglycans in pterygium tissues and normal conjunctiva.

    abstract::Glycosaminoglycans (GAG) in pterygium tissues were analyzed and the results were compared with those in the normal human conjunctiva. A marked difference in the GAG composition was found: 78% of the total hexosamines of GAG from pterygium was glucosamine, whereas 98% of those of the conjunctiva was galactosamine. Pter...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Kaneko M,Takaku I,Katsura N

    更新日期:1986-01-01 00:00:00

  • Disturbance of electrolyte balance in vitreous of chicks with form-deprivation myopia.

    abstract:PURPOSE:To investigate the changes in the electrolyte and protein concentrations in the vitreous of 3-week-old chicks with form-deprivation myopia (FDM). METHODS:FDM was induced in 2-day-old male white leghorn chicks by covering the left eye with a translucent plastic goggle and leaving the right eye uncovered to serv...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(99)00177-x

    authors: Seko Y,Shimokawa H,Pang J,Tokoro T

    更新日期:2000-01-01 00:00:00

  • Posterior subtenon infusion of triamcinolone acetonide as adjunctive treatment to panretinal photocoagulation using pattern scan laser for diabetic retinopathy.

    abstract:PURPOSE:To estimate the effect of sub-Tenon's capsule triamcinolone acetonide injection (STTA) combined with panretinal photocoagulation (PRP) using pattern scan laser (PSL) for high risk non-proliferative diabetic retinopathy (NPDR), in terms of the inflammation and the progression of diabetic macular edema (DME). ST...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-018-0628-z

    authors: Yamada Y,Takamura Y,Matsumura T,Morioka M,Gozawa M,Inatani M

    更新日期:2018-11-01 00:00:00

  • Viral conjunctivitis with special reference to adenovirus type 37 and enterovirus 70 infection.

    abstract::The clinical and etiological findings in 727 patients with viral conjunctivitis treated from January 1982 through December 1984 at Aoki Eye Clinic in Sapporo, Japan, were presented. The age of the patients ranged from 11 days to 88 years, and the monthly incidences of the disease from 18 to 131 cases, with a clusterin...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Aoki K,Kawana R,Matsumoto I,Wadell G,de Jong JC

    更新日期:1986-01-01 00:00:00

  • Transconjunctival immunotherapy using cholera toxin B to treat experimental allergic conjunctivitis in a mouse model.

    abstract:PURPOSE:We evaluated the use of immunological biomarkers in transconjunctival immunotherapy by using cholera toxin B for treating experimental allergic conjunctivitis in a mouse model. METHODS:Balb/c mice were sensitized using intraperitoneal injections of ovalbumin (OVA) and were then divided into two groups. The fir...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-011-0047-x

    authors: Oikawa A,Shoji J,Inada N,Sawa M

    更新日期:2011-09-01 00:00:00

  • Effects of stimulus contrast on binocular VER.

    abstract::The effect of stimulus contrast changes on the binocular visual evoked response (VER) was investigated using pattern reversal VER, dichoptic stimulation, and Fast Fourier Transform. When the stimulus contrast was changed binocularly, the monocular components increased as the contrast increased. The binocular component...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Katsumi O,Oguchi Y,Kawara T,Peli E

    更新日期:1984-01-01 00:00:00

  • Effects of tetramethylpyrazine on prostaglandin E(2)- and prostaglandin E(2) receptor agonist-induced disruption of blood-aqueous barrier in pigmented rabbits.

    abstract:PURPOSE:To evaluate the effect of tetramethylpyrazine on the elevation of aqueous flare and intraocular pressure (IOP) induced by prostaglandin (PG) E(2) and PGE(2) receptor (EP) agonists. METHODS:PGE(2) or EP agonists (11-deoxy PGE(1), EP(2) agonist; 17-phenyl trinor PGE(2), EP(1) and EP(3) agonist; or sulprostone, E...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0021-5155(01)00320-3

    authors: Kitagawa K,Hayasaka S,Nagaki Y,Watanabe K

    更新日期:2001-05-01 00:00:00

  • Evaluation of corneal damage caused by iodine preparations using human corneal epithelial cells.

    abstract:PURPOSE:To compare the cytotoxicity of povidone-iodine solution (PVP-I) with that of polyvinyl alcohol-iodine solution (PAI) for ophthalmic use. METHODS:Cells of the human corneal epithelial cell line HCE-T were exposed to various dilutions of PVP-I or PAI, and the cytotoxicity of these two antiseptics was evaluated. ...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-014-0348-y

    authors: Shibata Y,Tanaka Y,Tomita T,Taogoshi T,Kimura Y,Chikama T,Kihira K

    更新日期:2014-11-01 00:00:00

  • Changes in conjunctival-scleral thickness after strabismus surgery measured with anterior segment optical coherence tomography.

    abstract:PURPOSE:To evaluate changes in conjunctival-scleral thickness following strabismus surgery with anterior segment optical coherence tomography (AS-OCT). STUDY DESIGN:Prospective, observational, consecutive case series. METHODS:Distances between the conjunctival epithelium and inner scleral wall were measured with AS-O...

    journal_title:Japanese journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10384-018-0609-2

    authors: Suzuki H,Hikoya A,Komori M,Inagaki R,Haseoka T,Arai S,Takagi Y,Hotta Y,Sato M

    更新日期:2018-09-01 00:00:00