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Colony-stimulating factor 1 (CSF-1) is involved in an autocrine growth control of rat myogenic cells.

Abstract：

:Colony stimulating factor-1 (CSF-1) and the CSF-1 receptor (the c-fms proto-oncogene product) are expressed during the proliferation of the L6 alpha 1 rat myogenic cell line and both are down-regulated during the differentiation to myotubes. Biologically active CSF-1 was shown to be secreted into the culture medium by L6 alpha 1 myoblasts and while they could not bind CSF-1, evidence was obtained for cell surface receptor-CSF-1 complexes. It was not possible to block the L6 alpha 1 proliferation by incubation with anti-CSF-1 antiserum or suramin. However, in L6 alpha 1 myoblasts that were stably transfected with an inducible anti-fms antisense construct, both c-fms protein expression and cell proliferation were more rapidly inhibited under induction and differentiation conditions than parental cells. Furthermore, under these conditions, the c-fms antisense transfected cells also entered myogenic differentiation more rapidly. These results suggest that autocrine regulation by CSF-1 that is intracellular may play a role in the proliferation of muscle cells and that its down-regulation leads to, and may be an obligatory step in, myogenesis.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Borycki AG,Smadja F,Stanley R,Leibovitch SA

doi

10.1006/excr.1995.1149

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

213-22

issue

1

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(85)71149-4

journal_volume

218

pub_type

杂志文章

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