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Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells.

Abstract：

:Homologous desensitization of responses to bombesin in small cell lung cancer cells can be mimicked by protein kinase C-activating phorbol esters. We show that phorbol ester-induced desensitization can be blocked by prior treatment with the protein kinase C inhibitor staurosporine or prolonged pretreatment with phorbol esters. However, under these conditions, homologous desensitization to bombesin persists. These data indicate that phorbol ester-induced desensitization is distinguishable from bombesin-induced homologous desensitization. Protein kinase C is not a dominant component in the homologous desensitization to bombesin in small cell lung cancer cells.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Frankel A,Viallet J

doi

10.1006/excr.1993.1327

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

398-401

issue

2

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(83)71327-3

journal_volume

209

pub_type

杂志文章

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