Beta-interferon for multiple sclerosis.

abstract：:Alexander disease (AxD) is a rare neurodegenerative disorder characterized by large cytoplasmic aggregates in astrocytes and myelin abnormalities and caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), the main intermediate filament protein in astrocytes. We tested the effects of ...

journal_title：Experimental cell research

authors： Mignot C,Delarasse C,Escaich S,Della Gaspera B,Noé E,Colucci-Guyon E,Babinet C,Pekny M,Vicart P,Boespflug-Tanguy O,Dautigny A,Rodriguez D,Pham-Dinh D

更新日期：2007-08-01 00:00:00

abstract：:Hyperglycemia is a primary factor that disturbs podocyte function in the glomerular filtration process; this disturbance leads to the development of diabetic nephropathy, and ultimately, renal failure. Podocyte function may also be altered by biological agents that modify protein kinase activity, including the cGMP-ac...

journal_title：Experimental cell research

authors： Piwkowska A,Rogacka D,Audzeyenka I,Angielski S,Jankowski M

更新日期：2014-01-01 00:00:00

abstract：:Replication protein A (RPA), a stable complex of three polypeptides, is the single-stranded DNA-binding protein essential for DNA replication in eukaryotic cells. Previous studies of the subcellular distribution and stability of the RPA heterotrimer during the mammalian cell cycle have produced conflicting results. He...

journal_title：Experimental cell research

authors： Dimitrova DS,Gilbert DM

更新日期：2000-02-01 00:00:00

abstract：:Previously, whole-mount electron microscopy of nuclei extruded together with residual cytoplasm from the rhizoids of several algal species of the order Dasycladales has revealed the occurrence of an intra- and perinuclear network of 10-nm filaments morphologically indistinguishable from that of mammalian vimentin inte...

journal_title：Experimental cell research

authors： Berger S,Wittke W,Traub P

更新日期：1998-05-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) promotes the motility of different cell types. We investigated the role of IGF-I receptor (IGF-IR) signaling in locomotion of MCF-7 breast cancer epithelial cells overexpressing the wild-type IGF-IR (MCF-7/IGF-IR). Stimulation of MCF-7/IGF-IR cells with 50 ng/ml IGF-I induced disru...

journal_title：Experimental cell research

authors： Guvakova MA,Surmacz E

更新日期：1999-08-25 00:00:00

abstract：:Treatment of NRK cells with TGF-alpha in the presence of serum initiates disassembly of cytoskeletal stress fibers and suppresses the synthesis of tropomyosin isoforms (TMs) 1, 2, and 3 but not TMs 4 and 5 (Cooper et al., Cancer Res. 47, 4493-4500, 1987). In order to determine how the loss of tropomyosin is induced an...

journal_title：Experimental cell research

authors： Warren RH

更新日期：1997-10-10 00:00:00

abstract：:Plasminogen activation is observed in the human epidermis during reepithelialization of epidermal defects and under certain pathological conditions. The activation reaction depends on keratinocyte-associated plasminogen activators (PAs), which convert the ubiquitous proenzyme plasminogen into the active trypsin-like s...

journal_title：Experimental cell research

authors： Reinartz J,Schaefer B,Bechtel MJ,Kramer MD

更新日期：1996-02-25 00:00:00

abstract：:Cystatins constitute a superfamily of cysteine protease inhibitors. A member of the type II secreted cystatin family, cystatin F, has been identified through different gene array experiments to be specifically expressed in hematopoietic cells as well as to be associated with several malignant tumors, suggesting a role...

journal_title：Experimental cell research

authors： Cappello F,Gatti E,Camossetto V,David A,Lelouard H,Pierre P

更新日期：2004-07-15 00:00:00

abstract：:Tendon is a critical unit of musculoskeletal system that connects muscle to bone to control bone movement. More population participate in physical activities, tendon injuries, such as acute tendon rupture and tendinopathy due to overuse, are common causing unbearable pain and disability. However, the process of tendon...

journal_title：Experimental cell research

authors： Lu YF,Chan KM,Li G,Zhang JF

更新日期：2016-02-15 00:00:00

abstract：:Breast tumor cells enter the bloodstream long before the development of clinically evident metastasis. However, the early presence of such bloodborne cells predicts poor patient outcome. Nearly 90% of human breast tumors arise as carcinomas from mammary epithelial cells, so it is important to study how these cells res...

journal_title：Experimental cell research

authors： Whipple RA,Cheung AM,Martin SS

更新日期：2007-04-15 00:00:00

abstract：:Inhibition of cAMP-dependent protein kinase activity by microinjection of a specific physiologic protein inhibitor into sea urchin eggs inhibits the first cleavage after fertilization. Inhibition apparently occurs at some time prior to or during formation of the mitotic spindle. Measurement of the total protein kinase...

journal_title：Experimental cell research

authors： Browne CL,Bower WA,Palazzo RE,Rebhun LI

更新日期：1990-05-01 00:00:00

abstract：:The ST6Gal-I glycosyltransferase, which adds alpha2-6-linked sialic acids to glycoproteins, is overexpressed in colon adenocarcinoma, and enzyme activity is correlated with tumor cell invasiveness. Previously we reported that forced expression of oncogenic ras in HD3 colonocytes causes upregulation of ST6Gal-I, leadin...

journal_title：Experimental cell research

authors： Shaikh FM,Seales EC,Clem WC,Hennessy KM,Zhuo Y,Bellis SL

更新日期：2008-10-01 00:00:00

abstract：:Unraveling the mechanisms underlying cellular senescence will contribute to the understanding of processes involved in aging and cancer. We sought to determine whether expression of cellular factors in senescent WI-38 human fibroblasts was sufficient to induce nuclear DNA synthesis. Expression by recombinant adenoviru...

journal_title：Experimental cell research

authors： Sarraj S,Farb R,Martell RE

更新日期：2001-11-01 00:00:00

abstract：:In the fungus Achlya, sexual development in the male strain E87 is mediated by the steroid hormone antheridiol. Treatment of vegetatively growing cells of E87 with antheridiol resulted in changes in the [35S]methionine labeling of several secreted proteins. The most heavily labeled group of proteins observed in the se...

journal_title：Experimental cell research

authors： Brunt SA,Silver JC

更新日期：1986-03-01 00:00:00

abstract：:Various cell adhesion molecules mediate the diverse functions of the vascular endothelium, such as cell adhesion, neutrophil migration, and angiogenesis. In order to identify cell adhesion molecules important for angiogenesis, we used an in vitro model (Chalupowicz, Chowdhury, Bach, Barsigian, and Martinez, J. Cell Bi...

journal_title：Experimental cell research

authors： Bach TL,Barsigian C,Chalupowicz DG,Busler D,Yaen CH,Grant DS,Martinez J

更新日期：1998-02-01 00:00:00

abstract：:Retinol binding protein (RBP) is the plasma transport protein of retinol. Mobilization of RBP from the liver stores is stimulated by retinol. During vitamin A deficiency, RBP secretion is specifically inhibited while its rate of biosynthesis is unaffected. As a consequence, RBP, as apoprotein, accumulates inside the e...

journal_title：Experimental cell research

authors： Tosetti F,Ferrari N,Pfeffer U,Brigati C,Vidali G

更新日期：1992-06-01 00:00:00

abstract：:We have studied the internalization of targeted fusogenic liposome content to leukemic T cells (CEM) in vitro. We describe a method for the covalent coupling of T101 antibody to the surface of liposomes and the incorporation of fusogenic viral protein into the liposome membrane. Hygromycin B, an impermeant inhibitor o...

journal_title：Experimental cell research

authors： Sechoy O,Vidal M,Philippot JR,Bienvenue A

更新日期：1989-11-01 00:00:00

abstract：:Specific mitochondrial incorporation of 10 N-nonyl acridine orange (NAO) is demonstrated by subcellular fractionation of rat hepatocytes. Moreover, comparative studies with NAO and rhodamine 123 (Rh 123) prove that acridine orange-derivative uptake is independent of transmembrane mitochondrial potential, a property al...

journal_title：Experimental cell research

authors： Leprat P,Ratinaud MH,Maftah A,Petit JM,Julien R

更新日期：1990-01-01 00:00:00

abstract：:Small vertebrate organisms have emerged as key players in the post-genomic era for the functional characterization of novel genes on a high-throughput scale. In this context, the zebrafish embryos and Xenopus tadpoles represent attractive and valuable models to rapidly identify and characterize novel genes involved in...

journal_title：Experimental cell research

authors： Ny A,Autiero M,Carmeliet P

更新日期：2006-03-10 00:00:00

abstract：:The mammalian Hippo pathway comprises mammalian Ste20-like kinases (MST1/2) and large tumor suppressor kinases (LATS1/2). LATS1/2, which are activated by MST1/2, phosphorylate a transcriptional co-activator, yes-associated protein (YAP), and induce the recruitment of YAP by 14-3-3 to cytoplasm, so that the TEAD-depend...

journal_title：Experimental cell research

authors： Iwasa H,Maimaiti S,Kuroyanagi H,Kawano S,Inami K,Timalsina S,Ikeda M,Nakagawa K,Hata Y

更新日期：2013-04-15 00:00:00

abstract：:Topoisomerase II is essential for cell proliferation and survival and has been a target of various anticancer drugs. ICRF-193 has long been used as a catalytic inhibitor to study the function of topoisomerase II. Here, we show that ICRF-193 treatment induces DNA damage signaling. Treatment with ICRF-193 induced G2 arr...

journal_title：Experimental cell research

authors： Park I,Avraham HK

更新日期：2006-07-01 00:00:00

abstract：:Pluripotent stem cell activity is essential to maintain regeneration and homeostasis in the Drosophila midgut following environmental challenges. Although multiple pathways have been implicated in epithelial renewal, the underlying regulatory mechanisms and correlations between relevant genes and pathways remain elusi...

journal_title：Experimental cell research

authors： Liu Q,Jin LH

更新日期：2017-12-15 00:00:00

abstract：:Cellular senescence is a state of irreversible cell cycle arrest in which normal cells at the end of their lifespan fail to enter into DNA synthesis upon serum or growth factor stimulation. We examined whether proteins required for G1/S cell cycle progression were irreversibly down-regulated in senescent human fibrobl...

journal_title：Experimental cell research

authors： Afshari CA,Vojta PJ,Annab LA,Futreal PA,Willard TB,Barrett JC

更新日期：1993-12-01 00:00:00

abstract：:A monoclonal antibody specific for vimentin is described which, by immunofluorescence and immunoelectron microscopy, decorates fibrillar and/or granular structures in mitotic and early postmitotic cells but does not react with vimentin filaments of interphase stages of various cultured cells (rat vascular smooth muscl...

journal_title：Experimental cell research

authors： Franke WW,Grund C,Kuhn C,Lehto VP,Virtanen I

更新日期：1984-10-01 00:00:00

abstract：:The aging proteostasis decline manifests in a failure of aging cells and organisms to properly respond to proteotoxic challenges. This proteostasis collapse has long been considered a hallmark of aging in nematodes, and has recently been shown to occur also in human cells upon entry to senescence, opening the way to e...

journal_title：Experimental cell research

authors： Meller A,Shalgi R

更新日期：2021-01-09 00:00:00

abstract：:Evidence is presented that endonuclease digestion of isolated, unfixed chromosomes results in the production of banding patterns similar to those produced by digestion of fixed, air-dried chromosomes. Mouse L cell chromosomes were isolated under acidic or relatively neutral pH conditions, exposed in situ (as wet mount...

journal_title：Experimental cell research

authors： Burkholder GD,Schmidt GJ

更新日期：1986-06-01 00:00:00

abstract：:Prosomes constitute the multicatalytic proteinase (MCP) core of the 26S proteasomes, but were first observed as subcomplexes of untranslated mRNP; this suggests that they play a putative role in the control of protein biosynthesis in addition to their catabolic enzymatic function. In previous investigations it was sho...

journal_title：Experimental cell research

authors： De Conto F,Missorini S,Arcangeletti C,Pinardi F,Montarras D,Pinset C,Vassy J,Géraud G,Chezzi C,Scherrer K

更新日期：1997-05-25 00:00:00

abstract：:The stimulation of human tumor cells overexpressing epidermal growth factor receptor (EGFR) with EGF enhances tumor development and malignancy. Therefore, compounds that modulate the EGF-mediated signal inducing apoptosis in EGFR-overexpressing cells would represent a new class of antitumor drug and might be useful in...

journal_title：Experimental cell research

authors： Yoshimoto Y,Imoto M

更新日期：2002-09-10 00:00:00

abstract：:The assumption that cells are temporally organized systems, i.e. showing relevant dynamics of their state variables such as gene expression or protein and metabolite concentration, while tacitly given for granted at the molecular level, is not explicitly taken into account when interpreting biological experimental dat...

journal_title：Experimental cell research

authors： Romagnoli G,Cundari E,Negri R,Crescenzi M,Farina L,Giuliani A,Bianchi MM

更新日期：2011-12-10 00:00:00

abstract：:Cell surface beta-1,4-galactosyltransferase (GalTase) partially mediates a variety of cell interactions with laminin-containing matrices, including mesenchymal cell spreading and migration and neurite initiation, by binding to N-linked oligosaccharides within the E8 domain of laminin. Previous studies using indirect i...

journal_title：Experimental cell research

authors： Eckstein DJ,Shur BD

更新日期：1992-07-01 00:00:00