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The zinc finger protein CG12744 is essential for differentiation and regeneration after infection in the adult Drosophila midgut.

Abstract：

:Pluripotent stem cell activity is essential to maintain regeneration and homeostasis in the Drosophila midgut following environmental challenges. Although multiple pathways have been implicated in epithelial renewal, the underlying regulatory mechanisms and correlations between relevant genes and pathways remain elusive. In this study, we show that the zinc finger protein CG12744 plays an important role in the differentiation and regeneration of epithelial cells in response to oral infection with Erwinia carotovora carotovora 15. Knocking down CG12744 in enteroblasts decreased the post-infection proportion of enteroblasts and enterocytes and increased the post-infection number of enteroendocrine cells. In addition, in precursors, CG12744 affected the Osa, jun-N-terminal kinase and bone morphogenetic protein signaling pathways to control enterocyte differentiation. Finally, CG12744 maintained epithelial architecture and cell fate in enterocytes following an acute infectious challenge.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Liu Q,Jin LH

doi

10.1016/j.yexcr.2017.10.021

subject

Has Abstract

pub_date

2017-12-15 00:00:00

pages

225-235

issue

2

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(17)30568-2

journal_volume

361

pub_type

杂志文章

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