The blocked pinocytic activity of mitotic cells is restored in mitotic-interphase hybrids.

abstract：:Rabbit antisera prepared against embryonic chick liver cells have been characterized using cell cytotoxicity tests, antibody absorption tests, inhibition of cell-cell reaggregation and cell-aggregate adhesion assays. The sera contain antibodies which specifically block embryonic chick liver cell-cell aggregation with ...

journal_title：Experimental cell research

authors： Grady SR,Nielsen LD,McGuire EJ

更新日期：1982-11-01 00:00:00

abstract：:AP-1/cJun, NF-kappaB and STAT3 transcription factors control expression of numerous genes, which regulate critical cell functions including proliferation, survival and apoptosis. Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, th...

journal_title：Experimental cell research

authors： Ivanov VN,Hei TK

更新日期：2006-12-10 00:00:00

abstract：:Among different cancers, incidence and mortality of colorectal cancer (CRC) is one of the highest. KRAS mutation is one of the underlying features in the pathogenesis of CRC with CRC tumors harboring mutant KRAS exhibiting a more aggressive behavior compared to CRC tumors with wild type KRAS. We had earlier shown that...

journal_title：Experimental cell research

authors： Li S,Fang XD,Wang XY,Fei BY

更新日期：2018-12-15 00:00:00

abstract：:The K63-linked ubiquitination of RIP1 coordinates survival/death homeostasis by driving transcription of genes downstream of RelA. Previously, we demonstrated that EGF-dependent RelA transactivation overcomes hypoxia-initiated apoptosis, yet the underlying mechanisms remain mysterious. We report here that UBXN1 defici...

journal_title：Experimental cell research

authors： Song YK,Hu BC,Xu L,Liu JQ,Chen X,Zheng Y,Chen MH,Wang JZ,Sun RH,Mo SJ

更新日期：2019-05-01 00:00:00

abstract：:There are a number of low-abundance small nuclear RNAs (snRNAs) in eukaryotic cells. Many of them have been assigned functions in the biogenesis of cellular RNAs, such as splicing and 3' end processing. Here, we present the sequence of Xenopus U12 snRNA and compare the secondary structures of the low-abundance U11 and...

journal_title：Experimental cell research

authors： Yu YT,Tarn WY,Yario TA,Steitz JA

更新日期：1996-12-15 00:00:00

abstract：:A monoclonal murine antibody (No-114) is described which reacts specifically with a polypeptide of molecular weight (Mr) 180 000 present in low-speed nuclear pellets from oocytes and somatic cells of Xenopus laevis and X. borealis and in isolated amplified nucleoli. Two-dimensional gel electrophoresis has revealed the...

journal_title：Experimental cell research

authors： Schmidt-Zachmann MS,Hügle B,Scheer U,Franke WW

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In recent years, immunotherapy for the treatment of tumors have been established. Dendritic cells (DCs) are extremely efficient and professional antigen presenting cells (APCs), which are an important target for immune therapeutic interventions in cancer. In present study, we investigated wheth...

journal_title：Experimental cell research

authors： Gao X,Han D,Fan W

更新日期：2016-12-10 00:00:00

abstract：:Two HL60 clones (C12 and C13) totally insensitive to differentiation induction by dimethylsulfoxide (Me2SO) are described. They have been growing continuously in the presence of the inducer for more than 6 months. The morphological and cytochemical features of the two populations are quite similar to those of the orig...

journal_title：Experimental cell research

authors： Ferrero D,Gallo E,Lanfrancone L,Tarella C

更新日期：1983-08-01 00:00:00

abstract：:Rat myotubes in tissue culture form broad areas of close contact with the substrate. These areas often display two distinct, interdigitating sets of membrane domains. One, the "contact domain", is close to the substrate; the other, termed the "AChR domain", is further from the substrate and is rich in acetylcholine re...

journal_title：Experimental cell research

authors： Bloch RJ,Velez M,Krikorian JG,Axelrod D

更新日期：1989-06-01 00:00:00

abstract：:An increase in tumour formation and metastasis are observed upon plakophilin3 (PKP3) loss. To identify pathways downstream of PKP3 loss that are required for increased tumour formation, a gene expression analysis was performed, which demonstrated that the expression of lipocalin2 (LCN2) was elevated upon PKP3 loss and...

journal_title：Experimental cell research

authors： Basu S,Chaudhary N,Shah S,Braggs C,Sawant A,Vaz S,Thorat R,Gupta S,Dalal SN

更新日期：2018-08-15 00:00:00

abstract：:The epidermal growth factor (EGF) receptor is well known as a mediator of mitogenic signaling and its tyrosine kinase activity has been suggested as a viable target in cancer chemotherapy. To explore the consequences of abolishing the kinase activity of this receptor, we have utilized a potent and specific inhibitor o...

journal_title：Experimental cell research

authors： Nelson JM,Fry DW

更新日期：1997-06-15 00:00:00

abstract：:Human dental follicle cells (DFCs) and periodontal ligament cells (PDLCs) derived from the ectomesenchymal tissue, have been shown to exhibit stem/progenitor cell properties and the ability to induce tissue regeneration. Stem cells in dental follicle differentiate into cementoblasts, periodontal ligament fibroblasts a...

journal_title：Experimental cell research

authors： Li J,Li H,Tian Y,Yang Y,Chen G,Guo W,Tian W

更新日期：2016-07-01 00:00:00

abstract：:We have shown previously that there is a good correlation between the degree of microtubule disassembly by methylmercury (MeHg) and the extent of inhibition of DNA replication in Concanavalin A (Con A)-stimulated mouse splenic lymphocytes. The purpose of this study was to determine if these two events are causally rel...

journal_title：Experimental cell research

authors： Roy C,Prasad KV,Reuhl KR,Little JE,Valentine BK,Brown DL

更新日期：1991-08-01 00:00:00

abstract：:Mdg1/ERdj4, a mammalian chaperone that belongs to the HSP40 protein family, has been reported to be located in the endoplasmic reticulum (ER), is induced by ER stress, and protects ER stressed cells from apoptosis. Here we show that under normal physiological conditions, Mdg1/ERdj4 is expressed at various levels in th...

journal_title：Experimental cell research

authors： Berger BJ,Müller TS,Buschmann IR,Peters K,Kirsch M,Christ B,Pröls F

更新日期：2003-10-15 00:00:00

abstract：:Accumulating evidence has suggested that thyroid hormone receptor interacting protein 6 (TRIP6) is a novel tumor-related regulator that is aberrantly expressed in multiple tumors and contributes to tumor progression and metastasis. Yet, little is known about the role of TRIP6 in cervical cancer. In the current study, ...

journal_title：Experimental cell research

authors： Yang F,Li L,Zhang J,Zhang J,Yang L

更新日期：2020-11-01 00:00:00

abstract：:tsJT60, a temperature-sensitive (ts) cell-cycle mutant of Fischer rats, is viable at both the permissive (34 degrees C) and nonpermissive (40 degrees C) temperatures. The cells grow normally in exponential growth phase at both temperatures, but when stimulated with serum from G0 phase they enter S phase at 34 degrees ...

journal_title：Experimental cell research

authors： Tai YY,Goto Y,Ninomiya-Tsuji J,Kameoka Y,Ishibashi S,Shiroki K,Ide T

更新日期：1988-11-01 00:00:00

abstract：:The importance of mononuclear leukocyte (MO) adhesion to dysfunctional endothelium and migration to the subendothelial space in the early phases of atherogenesis is well established. Few studies have addressed the relevance of polymorphonuclear leukocytes (PMNs) in the context of evolving lesions, and nothing is known...

journal_title：Experimental cell research

authors： Donetti E,Baetta R,Comparato C,Altana C,Sartore S,Paoletti R,Castano P,Gabbiani G,Corsini A

更新日期：2002-04-01 00:00:00

abstract：:Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subse...

journal_title：Experimental cell research

authors： Dong Z,Liu Z,Cui P,Pincheira R,Yang Y,Liu J,Zhang JT

更新日期：2009-07-01 00:00:00

abstract：:Integrins play a major role in cell adhesion and migration. Previous work reported that a cleaved form of integrin alpha6 (alpha6p) was detected in invasive human prostate cancer tissue, absent in normal prostate tissue and was produced by urokinase-type Plasminogen Activator (uPA) in a plasmin-independent manner. Usi...

journal_title：Experimental cell research

authors： Pawar SC,Demetriou MC,Nagle RB,Bowden GT,Cress AE

更新日期：2007-04-01 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) can modulate the activity of various MAP kinases. However, how this pathway may mediate TGFbeta-induced malignant phenotypes remains elusive. We investigated the role of autocrine TGFbeta signaling through MAP kinases in the regulation of cell survival in breast carcinoma MCF-...

journal_title：Experimental cell research

authors： Lei X,Yang J,Nichols RW,Sun LZ

更新日期：2007-05-01 00:00:00

abstract：:In this communication, we have studied a 72,000 mol w (p72) host protein which reacts with a mouse monoclonal antibody (PAb6) directed against antigenic determinants on the Simian virus 40 (SV40) large T antigen protein that map 5' of 0.42 map units on the viral genome. The p72 protein is an abundant basic (pI greater...

journal_title：Experimental cell research

authors： Ullrich SJ,Appella E,Mercer WE

更新日期：1988-10-01 00:00:00

abstract：:The proline analogs cis-4-hydroxy-L-proline, 3,4-dehydro-L-proline, and 2-azetidinecarboxylic acid induced increases in the migration rate of retinal capillary endothelial cells, aortal endothelial cells, corneal endothelial cells, aortal smooth muscle cells, and retinal pericytes. cis-4-hydroxy-D-proline did not. The...

journal_title：Experimental cell research

authors： McAuslan BR,Reilly W,Hannan GN,Schindhelm K,Milthorpe B,Saur BA

更新日期：1988-06-01 00:00:00

abstract：:Gicerin is a novel cell adhesion molecule in the immunoglobulin superfamily and has both homophilic adhesion and heterophilic adhesive activity to neurite outgrowth factor (NOF), an extracellular matrix protein in the laminin family. We investigated the possible involvement of gicerin in oviductal development, regener...

journal_title：Experimental cell research

authors： Tsukamoto Y,Taira E,Kajimura K,Yamate J,Kotani T,Amin H,Kohama K,Sakuma S,Miki N,Sasaki F

更新日期：1999-03-15 00:00:00

abstract：:Cell-matrix adhesion complexes are multi-protein structures linking the extracellular matrix (ECM) to the cytoskeleton. They are essential to both cell motility and function by bidirectionally sensing and transmitting mechanical and biochemical stimulations. Several types of cell-matrix adhesions have been identified ...

journal_title：Experimental cell research

authors： Li Z,Lee H,Zhu C

更新日期：2016-11-15 00:00:00

abstract：:Glycosaminoglycans (heparins, dermatan sulfate, chondroitin sulfate) with different structures and physicochemical properties were evaluated for their capacity to influence proliferation and differentiation of U-937 cell line. The contrasting and specific effects of glycosaminoglycans (depending on their structures an...

journal_title：Experimental cell research

authors： Volpi N,Petrini M,Conte A,Valentini P,Venturelli T,Bolognani L,Ronca G

更新日期：1994-11-01 00:00:00

abstract：:Bone morphogenetic protein-4 (BMP-4) is a member of the transforming growth factor-beta (TGF-beta) supergene family and is characterized by its ability to induce singly de novo cartilage and bone in vivo. The influence of recombinant bone morphogenetic protein-4 and some related members, TGF-beta 1, activin A, and inh...

journal_title：Experimental cell research

authors： Luyten FP,Chen P,Paralkar V,Reddi AH

更新日期：1994-02-01 00:00:00

abstract：:In confluent keratinocyte monolayers, desmosomal adhesion gradually becomes calcium-independent and this is associated with an increase in the strength of intercellular adhesion (hyper-adhesion). In this study, we investigated the functional and molecular significance of hyper-adhesion in a system challenged by autoim...

journal_title：Experimental cell research

authors： Cirillo N,Lanza A,Prime SS

更新日期：2010-02-15 00:00:00

abstract：:Epithelial ovarian cancer is the most common form of gynaecological malignancy. This lethal disease is thought to arise in ovarian surface epithelial (OSE) cells. The biology of these cells is not well understood, due to the limited amount of tissue that can be obtained from a single biopsy and their limited life span...

journal_title：Experimental cell research

authors： Davies BR,Steele IA,Edmondson RJ,Zwolinski SA,Saretzki G,von Zglinicki T,O'Hare MJ

更新日期：2003-08-15 00:00:00

abstract：:Mip130/LIN-9 is part of a large complex that includes homologs of the Drosophila dREAM (drosophila RB-like, E2F, and Myb) and C. elegans DRM complexes. This complex also includes proteins such as Mip40/LIN-37, Mip120/LIN-54, and LIN-52. In mammalian cells, Mip130/LIN-9 specifically associates with the p107/p130-E2F4 r...

journal_title：Experimental cell research

authors： Sandoval R,Pilkinton M,Colamonici OR

更新日期：2009-10-15 00:00:00

abstract：:The bioflavonoid quercetin is a dietary anticancer chemical that is capable of inducing apoptosis in tumor cells. Although the activity of quercetin is believed to be due to its antioxidative properties, it has recently been suggested that quercetin also has prooxidant activities, which might effect cytotoxicity direc...

journal_title：Experimental cell research

authors： Lee JC,Kim J,Park JK,Chung GH,Jang YS

更新日期：2003-12-10 00:00:00