Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.

abstract：:Thyroid hormone (T3) and estradiol (Est) modulate biological processes by binding to nuclear receptor proteins that, through interactions with specific response elements in the regulatory regions of genes, modulate gene transcription. Est stimulation of estrogen receptor (ER)-positive breast carcinoma cell growth occu...

journal_title：Experimental cell research

authors： Shao ZM,Sheikh MS,Rishi AK,Dawson MI,Li XS,Wilber JF,Feng P,Fontana JA

更新日期：1995-05-01 00:00:00

abstract：:Regions rich in 5-methylcytosine were localized in male metaphase chromosomes of the Indian muntjac deer (Muntiakus muntjak). Chromosomes were ultraviolet irradiated and subsequently photooxidized in the presence of methylene blue to induce maximum DNA denaturation. Following treatment with anti 5-methylcytosine antib...

journal_title：Experimental cell research

authors： Vasilikaki-Baker H,Nishioka Y

更新日期：1983-08-01 00:00:00

abstract：:Studies performed over the past five years have demonstrated that there are two major cell-intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death receptors and another that involves mitochondrial release of cytochrome c. Several reports have suggested that anticancer drugs kill ...

journal_title：Experimental cell research

authors： Kaufmann SH,Earnshaw WC

更新日期：2000-04-10 00:00:00

abstract：:Ubiquitylation of membrane receptors is recognised as a critical post-translational modification, governing their regulation and function. Following ubiquitylation, membrane proteins may be internalised, recycled or degraded via lysosomal or proteasomal pathways. Viruses have appropriated these cellular pathways as a ...

journal_title：Experimental cell research

authors： Nathan JA,Lehner PJ

更新日期：2009-05-15 00:00:00

abstract：:The development of Sjögren's syndrome (SS) is accompanied by B cell hyperproliferation and mutation. Our previous study identified aberrant expression of BST-2 (also known as Tetherin/CD317) in B cells from either the peripheral blood or infiltrated salivary glands. However, the roles of BST-2 in the regulation of B c...

journal_title：Experimental cell research

authors： Fu J,Shi H,Zhan T,Li H,Ye L,Xie L,Wang Z,Wang B,Zheng L

更新日期：2021-01-01 00:00:00

abstract：:Senescent human diploid fibroblasts, TIG-1, had labelling indices of about 0.5-3% when labelled with [3H]thymidine for 3 days in fresh medium containing 10% fetal bovine serum. When these cells were infected with SV40, the percentage of nuclei incorporating [3H]thymidine increased by about 10-fold. The frequency of T-...

journal_title：Experimental cell research

authors： Tsuji Y,Ide T,Ishibashi S

更新日期：1983-03-01 00:00:00

abstract：:The glomerular capillary endothelium is highly specialized to support the selective filtration of massive volumes of plasma. Filtration is driven by Starling forces acting across the glomerular capillary wall, and depends on its large surface area and extremely high water permeability. Glomerular endothelial cells are...

journal_title：Experimental cell research

authors： Obeidat M,Obeidat M,Ballermann BJ

更新日期：2012-05-15 00:00:00

abstract：:In this communication, we have studied a 72,000 mol w (p72) host protein which reacts with a mouse monoclonal antibody (PAb6) directed against antigenic determinants on the Simian virus 40 (SV40) large T antigen protein that map 5' of 0.42 map units on the viral genome. The p72 protein is an abundant basic (pI greater...

journal_title：Experimental cell research

authors： Ullrich SJ,Appella E,Mercer WE

更新日期：1988-10-01 00:00:00

abstract：:Phosphorylation of types III and IV intermediate filaments (IFs) is known to regulate their organization and function. Phosphorylation of the amino-terminal head domain sites on types III and IV IF proteins plays a key role in the assembly/disassembly of IF subunits into 10 nm filaments, and influences the phosphoryla...

journal_title：Experimental cell research

authors： Sihag RK,Inagaki M,Yamaguchi T,Shea TB,Pant HC

更新日期：2007-06-10 00:00:00

abstract：:Inorganic polyphosphate [Poly(P)] may represent a physiological source of phosphate and has the ability to induce bone differentiation in osteoblasts. We previously reported that cytokine-induced matrix metalloproteinase (MMP)-3 accelerates the proliferation of purified odontoblast-like cells. In this study, MMP-3 sma...

journal_title：Experimental cell research

authors： Ozeki N,Hase N,Yamaguchi H,Hiyama T,Kawai R,Kondo A,Nakata K,Mogi M

更新日期：2015-05-01 00:00:00

abstract：:The stroma, the middle layer of the cornea, is a connective tissue making up most of the corneal thickness. The stromal extracellular matrix (ECM) consists of highly organised lamellae which are made up of tightly packed fibrils primarily composed of collagens type I and V. This layer is interspersed with keratocytes,...

journal_title：Experimental cell research

authors： Greene CA,Green CR,Dickinson ME,Johnson V,Sherwin T

更新日期：2016-09-10 00:00:00

abstract：:The characteristics underlying cytosolic free calcium oscillation were evaluated by superfused dual wave-length microspectrofluorometry of fura-2-loaded single acinar cells from rat pancreas. Application of a physiological concentration of cholecystokinin octapeptide (CCK) (20 pM) induced a small basal increase in cyt...

journal_title：Experimental cell research

authors： Tsunoda Y

更新日期：1990-06-01 00:00:00

abstract：:Cholesterol and related compounds can give rise to oxygenated sterol molecules (oxysterols) which are potent regulators of lymphoid cell growth. Oxysterols added exogenously cause cell death of several lines of cultured cells, and on the basis of limited criteria, it has been suggested that this death is apoptosis. In...

journal_title：Experimental cell research

authors： Ayala-Torres S,Moller PC,Johnson BH,Thompson EB

更新日期：1997-08-25 00:00:00

abstract：:In the acute promyelocytic leukemia cell line NB4, Bcl-2 downregulation occurred as a late event of retinoid-induced differentiation. In the maturation-resistant NB4-R1 subclone, retinoids failed to downregulate Bcl-2 even in the situation of apoptosis massively induced by pan-agonists and RXR-selective agonists. We o...

journal_title：Experimental cell research

authors： Bruel A,Karsenty E,Schmid M,McDonnell TJ,Lanotte M

更新日期：1997-06-15 00:00:00

abstract：:This study deals with the effects of hyper- and hypo-osmotic media on the ultrastructure of four different types of cells and tissues: rat pheochromocytoma cells of line PC12, mouse Ehrlich ascites tumor cells, rat kidney cortex and intestine. Application of hyper-osmotic conditions induces in the nuclear compartment ...

journal_title：Experimental cell research

authors： Delpire E,Duchêne C,Goessens G,Gilles R

更新日期：1985-09-01 00:00:00

abstract：:An adenocarcinoma cell line which has the ability to arrest in G0 phase under exhausted culture conditions was established. Using the cell line, we investigated the expression of cell cycle-associated proteins including cdc2, cdk2, cyclin A, cyclin Dl, and Rb during entry into or withdrawal from the cell cycle. MAP ki...

journal_title：Experimental cell research

authors： Ohta T,Fukuda M,Wanebo HJ,Jogo K,Yamaguchi S

更新日期：1996-05-25 00:00:00

abstract：:The intracellular compartmentation of Ap4A in various growth and cell-cycle stages in mammalian cells was studied by applying a non-aqueous extraction procedure for cell nuclei. In both slowly and in exponentially growing Ehrlich ascites tumour cells from random cultures, more than 75% of the whole cellular Ap4A conte...

journal_title：Experimental cell research

authors： Weinmann-Dorsch C,Grummt F

更新日期：1986-08-01 00:00:00

abstract：:An in vitro system has been employed to study the apoptotic mechanisms in the AK-5 tumor which is a spontaneously regressing rat histiocytoma. Cytosolic extracts of tumor cells primed for apoptosis using dexamethasone and immune serum from tumor-regressing animals were able to induce apoptosis in intact nuclei and rep...

journal_title：Experimental cell research

authors： Anjum R,Khar A

更新日期：1997-11-01 00:00:00

abstract：:A novel C3G isoform, designated p87C3G, lacking the most amino terminal region of the cognate protein has been found to be overexpressed in two CML cell lines, K562 and Boff 210, both expressing Bcr-Abl p210. p87C3G expression is also highly augmented in patients diagnosed with chronic myeloid leukemia (CML) Ph+, in c...

journal_title：Experimental cell research

authors： Gutiérrez-Berzal J,Castellano E,Martín-Encabo S,Gutiérrez-Cianca N,Hernández JM,Santos E,Guerrero C

更新日期：2006-04-01 00:00:00

abstract：:Fibronectin and alpha 1(I) and alpha 2(I) collagen proteins and RNAs are highly expressed during the growth phase of the non-transformed L6 alpha 1 rat myoblasts. When L6 alpha 1 cells from myotubes following transfer to low serum medium, the levels of fibronectin RNA decrease 8-fold, those of both alpha 2(I) transcri...

journal_title：Experimental cell research

authors： Leibovitch SA,Hillion J,Leibovitch MP,Guillier M,Schmitz A,Harel J

更新日期：1986-10-01 00:00:00

abstract：:In this study, we demonstrate that protein kinase C (PKC) activators, including phorbol-12-myristate-13-acetate (PMA), 1,2-dioctanoyl-sn-glycerol (DOG), and platelet-derived growth factor alpha are potent inducers of angiopoietin-like protein 4 (ANGPTL4) expression in several normal lung cell types and carcinoma cell ...

journal_title：Experimental cell research

authors： Stapleton CM,Joo JH,Kim YS,Liao G,Panettieri RA Jr,Jetten AM

更新日期：2010-02-15 00:00:00

abstract：:Microtubule-binding proteins provide an alternative and vital pathway to the functional diversity of microtubules. Considerable work is still required to understand the complexities of microtubule-associated cellular processes and to identify novel microtubule-binding proteins. In this study, we identify Bcl2-associat...

journal_title：Experimental cell research

authors： He X,Zhang Y,Yang L,Feng J,Yang S,Li T,Zhong T,Li Q,Xie W,Liu M,Zhou J,Li D,Xie S

更新日期：2020-02-01 00:00:00

abstract：:This study shows the sensitivity of insulin-secreting RIN m5F cells to undergoing apoptosis without modifying intracellular free calcium concentrations. The culture of cells in the absence of serum during 6 h failed to produce spontaneous DNA fragmentation. However, when cultures were carried out in the presence of th...

journal_title：Experimental cell research

authors： Sánchez-Margalet V,Lucas M,Solano F,Goberna R

更新日期：1993-11-01 00:00:00

abstract：:Giant axonal neuropathy skin fibroblasts, which are characterized by a selective and partial disorganization of vimentin filaments [1] exhibited, when compared with normal skin fibroblasts, less fibrin clot retractile (FCR) activity and spreading within the fibrin clot both during active growth and resting stage. Skin...

journal_title：Experimental cell research

authors： Azzarone B,Macieira-Coelho A

更新日期：1984-11-01 00:00:00

abstract：:A popular criterion of cell-cell communication in tissue cultures is dye coupling: the ability of the injected fluorescent dye of low molecular weight to be transferred from one cell to another. We report about a new factor which induces cell-to-cell dye coupling in previously uncoupled epithelial sheets. Paradoxicall...

journal_title：Experimental cell research

authors： Sharovskaja YuYu,Chailakhjan LM,Margolis LB

更新日期：1988-04-01 00:00:00

abstract：:Spindle assembly is essential for the equal distribution of genetic material to the daughter cells during mitosis. The process of spindle assembly is complicated and involves multiple levels of molecular regulation. It is generally accepted that mitotic spindles are emanated from the centrosomes and are assembled in t...

journal_title：Experimental cell research

authors： Yang CP,Fan SS

更新日期：2008-10-15 00:00:00

abstract：:A monoclonal antibody raised against microtubule-associated protein-1 (MAP-1) binds to nuclei of normal human fibroblasts, its binding site being detected as intranuclear immunofluorescent dots. The percentage of cells showing these dots increased with insulin, hydrocortisone, epidermal growth factor (EGF), and transf...

journal_title：Experimental cell research

authors： Ohno T,Ohkawa A,Sato C

更新日期：1985-06-01 00:00:00

abstract：:Reversible methylation of the protein phosphatase 2A catalytic subunit (PP2A(C)(1)) is an important regulatory mechanism playing a crucial role in the selective recruitment of regulatory B subunits. Here, we investigated the subcellular localization of leucine carboxyl methyltransferase (LCMT1) and protein phosphatase...

journal_title：Experimental cell research

authors： Longin S,Zwaenepoel K,Martens E,Louis JV,Rondelez E,Goris J,Janssens V

更新日期：2008-01-01 00:00:00

abstract：:Endothelial cells are exposed to fluid shear stress profiles that vary in magnitude, pulsatility, and directionality due to regional variations in blood vessel structure. Laminar flow at physiological levels is atheroprotective; multidirectional or reversing low (disturbed) flow promotes inflammation and disease; and ...

journal_title：Experimental cell research

authors： Min E,Schwartz MA

更新日期：2019-03-01 00:00:00

abstract：:This study was designed to elucidate the mechanisms involved in elevated cell death arising from an altered endogenous oxidant state. Increased levels of cell death were detected in cells lacking Gpx1 following the addition of exogenous H2O2. This increased apoptosis correlated with a down-regulation in the activation...

journal_title：Experimental cell research

authors： Taylor JM,Crack PJ,Gould JA,Ali U,Hertzog PJ,Iannello RC

更新日期：2004-11-01 00:00:00