Abstract:
:Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In this study, we examined the expression profile of eIF3a in cell cycle and its role in cell cycle progression. We found that eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution. However, eIF3a appears to play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Dong Z,Liu Z,Cui P,Pincheira R,Yang Y,Liu J,Zhang JTdoi
10.1016/j.yexcr.2009.03.009subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1889-94issue
11eissn
0014-4827issn
1090-2422pii
S0014-4827(09)00124-4journal_volume
315pub_type
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