Abstract:
:Autophagy is an intracellular degradation pathway that is highly conserved during the evolution of eukaryotes and is based on lysosome. Under nutritional deficiencies or stress, cells can clear damaged and necrotic organelles and proteins through autophagy to maintain the homeostasis of cells and organisms. Studies have found that abnormal autophagy is closely related to the occurrence and development of neurodegenerative diseases and tumors. In order to further understand the relationship between lysosomes and autophagy, tumorigenesis and drug resistance, the role of autophagy-lysosomal pathway in tumor resistance and related mechanisms and the relationship between drug resistance and hypoxia-induced autophagy are discussed in this paper.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Li J,Liu G,Li L,Yao Z,Huang Jdoi
10.1016/j.yexcr.2020.111925subject
Has Abstractpub_date
2020-04-15 00:00:00pages
111925issue
2eissn
0014-4827issn
1090-2422pii
S0014-4827(20)30130-0journal_volume
389pub_type
杂志文章,评审abstract::β-Catenin signaling plays a pivotal role in the genesis of a variety of malignant tumors, but its role in breast cancer has not been fully elucidated. Here, we examined whether deregulation of β-catenin signaling is related to the aggressive characteristics of certain types of breast cancers. Analysis of cytokine leve...
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