Abstract：
:The epigenetic states of key regulatory genes must be altered to drive cell fate decisions in differentiating cells. This process must be coupled, at least transiently, to the DNA replication machinery. Only a few genes, however, have been shown to require DNA replication for their activation or repression upon induction of differentiation. We have developed a methodology for examining how gene expression is coupled to cell division during the early stages of differentiation of embryonal carcinoma (EC) cells. Using this approach, we find that the expression of the 5-hydroxytryptamine (serotonin) receptor 2C (Htr2c) is strongly increased in the second division after all-trans retinoic acid addition. We propose that the epigenetic activation of Htr2c in EC cells results from a chromatin remodeling process that requires at least two passages through S phase.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Bancescu DL,Glatt-Deeley H,Lalande Mdoi
10.1016/j.yexcr.2004.04.021keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
262-7issue
1eissn
0014-4827issn
1090-2422pii
S0014482704002381journal_volume
298pub_type
杂志文章abstract：:Interleukin 3 (IL-3) stimulates the growth of various types of hemopoietic progenitors. In vitro, survival of a series of murine cell lines derived from either neoplastic or nonneoplastic hemopoietic tissue shows a strict IL-3 dependence. In order to test the implication of energy metabolism in this dependence as clai...
journal_title：Experimental cell research
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doi：10.1016/0014-4827(90)90182-a
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journal_title：Experimental cell research
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journal_title：Experimental cell research
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journal_title：Experimental cell research
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journal_title：Experimental cell research
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