ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.

abstract：:The alpha 3 beta 1 integrin has been implicated as a receptor for several matrix components, including collagen, fibronectin, and laminins. The function of alpha 3 beta 1 seems to be very versatile involving cell adhesion to or migration on ECM, establishment of cell-cell contacts in aggregates, as well as linkage to ...

journal_title：Experimental cell research

authors： Lichtner RB,Howlett AR,Lerch M,Xuan JA,Brink J,Langton-Webster B,Schneider MR

更新日期：1998-05-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold tremendous potential for the development of new regenerative medicine therapies and the study of molecular mechanisms of pluripotency and development. However, reactivation of c-Myc, which results in tumor formation in chimeric mice, is a major roadblock in the translation o...

journal_title：Experimental cell research

authors： Habib O,Habib G,Choi HW,Hong KS,Do JT,Moon SH,Chung HM

更新日期：2013-12-10 00:00:00

abstract：:Pair formation in the hypotrichous ciliate Euplotes octocarinatus is a poorly understood phenomenon. In order to obtain information about the molecules involved in this process, we compared ciliary and cell body-associated glycoconjugates of non-mating-competent, mating-competent, and conjugating cells. Detection of g...

journal_title：Experimental cell research

authors： Plümper E,Freiburg M,Heckmann K

更新日期：1995-04-01 00:00:00

abstract：:The p70 ribosomal S6 kinase (S6K1) is rapidly activated following growth factor stimulation of quiescent fibroblasts and inhibition of this enzyme results in a G(1) arrest. Phosphorylation of the ribosomal S6 protein by S6K1 regulates the translation of both ribosomal proteins and initiation factors, leading to an inc...

journal_title：Experimental cell research

authors： Zhang H,Hoff H,Marinucci T,Cristofalo VJ,Sell C

更新日期：2000-08-25 00:00:00

abstract：:The goal of this study was to assess the in vitro differentiation capacity of human bone marrow-derived stem cells (hBMSCs) along retinal lineages. Mononuclear cells (MNC) were isolated from bone marrow (BM) and mobilized peripheral blood (mPB) using Ficoll-Paque density gradient centrifugation, and were sorted by mag...

journal_title：Experimental cell research

authors： Mathivanan I,Trepp C,Brunold C,Baerlocher G,Enzmann V

更新日期：2015-04-10 00:00:00

abstract：:Neuromedin B (NMB) is one of the bombesin-like peptides in mammals. Recently, bombesin-like peptides have been characterized as growth factors in highly vascularized tumors. In this study, we report that NMB potently stimulates in vivo neovascularization in a mouse Matrigel plug and the sprouting of endothelial cells ...

journal_title：Experimental cell research

authors： Park HJ,Kim SR,Bae SK,Choi YK,Bae YH,Kim EC,Kim WJ,Jang HO,Yun I,Kim YM,Bae MK

更新日期：2009-11-15 00:00:00

abstract：:When micromeres isolated from the 16-cell stage of Strongylocentrotus purpuratus are cultured in sea water containing 3.5% horse serum, they produce spicules at approximately the same time as in normal development. The serum requirement of the micromeres has been investigated by adding serum at varying intervals after...

journal_title：Experimental cell research

authors： McCarthy RA,Spiegel M

更新日期：1983-12-01 00:00:00

abstract：:In multiple myeloma, which commonly depends on interleukin 6, IL-6, survival signaling induced by this cytokine is largely mediated by activation of STAT3. Interferon alpha (IFNalpha) treatment of cell lines derived from multiple myeloma or of myeloma tumor cells ex vivo leads to apoptosis. In this study we demonstrat...

journal_title：Experimental cell research

authors： Thyrell L,Arulampalam V,Hjortsberg L,Farnebo M,Grandér D,Pokrovskaja Tamm K

更新日期：2007-11-15 00:00:00

abstract：:New methods have been developed for the purification and characterization of the cell wall degrading enzyme, lysin, which is released into the medium during the mating reaction of the biflagellated alga Chlamydomonas reinhardtii. A quantitative spectrophotometric assay that detects the number of cells losing walls was...

journal_title：Experimental cell research

authors： Buchanan MJ,Snell WJ

更新日期：1988-11-01 00:00:00

abstract：:Annexin 2 is a Ca(2+)-dependent phospholipid-binding protein that is involved in secretion. Despite the fact that this protein does not have signals for its secretion, many reports have shown its presence in the extracellular milieu. Here we demonstrate that, upon stimulation of exocytosis in chromaffin cells, a fract...

journal_title：Experimental cell research

authors： Faure AV,Migné C,Devilliers G,Ayala-Sanmartin J

更新日期：2002-05-15 00:00:00

abstract：:Breast cancer and prostate cancer are the most common malignant tumors in female and men, respectively. Furthermore, lung cancer is the leading cause of cancer deaths worldwide. It is an emergency to develop a powerful strategy to treat these threatening cancers more effectively, because of low efficacy and high rates...

journal_title：Experimental cell research

authors： Karbasforooshan H,Roohbakhsh A,Karimi G

更新日期：2018-06-01 00:00:00

abstract：:Uptake and metabolism of thymidine and adenosine have been studied in embryos of the sea urchin Strongylocentrotus purpuratus. Uptake of these nucleosides is found to be mutually competitive, with the Km for uptake of thymidine similar to its Ki for inhibition of adenosine uptake and vice versa. The metabolic studies ...

journal_title：Experimental cell research

authors： Schneider EG,Whitten DJ

更新日期：1987-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) has led to kinds of clinical disorders and great morbidity worldwide, such as sensorineural hearing loss (SNHL), mental retardation, and developmental delays in immunocompromised individuals. Congenital HCMV infection is a leading cause of birth defects, primarily manifesting as neurologic...

journal_title：Experimental cell research

authors： He X,Teng J,Cui C,Li D,Wen L

更新日期：2018-08-15 00:00:00

abstract：:The process of osteoblast differentiation and matrix mineralization requires a rise in alkaline phosphatase enzymatic activity resulting in the generation of free phosphate. The ability of inorganic phosphate to regulate gene transcription and cellular function represents a potentially novel extracellular signaling me...

journal_title：Experimental cell research

authors： Beck GR Jr,Moran E,Knecht N

更新日期：2003-08-15 00:00:00

abstract：:A two-site radio-immunoassay for beta NGF demonstrated 5-10 pg of NGF in the normal, adult rat iris. Ciliarectomy or sympathectomy did not significantly alter the amount of NGF after 10 days. However, denervation including all sensory axons (stereotactic lesion distal to the trigeminal ganglion) increased the level to...

journal_title：Experimental cell research

authors： Ebendal T,Olson L,Seiger A

更新日期：1983-10-15 00:00:00

abstract：:In this study an amphotropic retrovirus has been used to efficiently transduce normal human (NF) and scleroderma (systemic sclerosis; SSc) dermal fibroblasts (SScF) with a sequence encoding a temperature-sensitive mutant of the SV40 large T antigen (tsA58-U19). From the primary outgrowths of skin explants, cultures we...

journal_title：Experimental cell research

authors： Xu S,Vancheeswaran R,Bou-Gharios G,O'Hare MJ,Olsen I,Abraham D,Black C

更新日期：1995-10-01 00:00:00

abstract：:Activation of growth factor receptors, such as platelet-derived growth factor (PDGF) receptors, has a major impact on the motile behavior of vertebrate cells. The WASP family of proteins has been recognized as important regulators of actin polymerization via the activation of the Arp2/3 complex. The activity of the WA...

journal_title：Experimental cell research

authors： Aspenström P

更新日期：2002-09-10 00:00:00

abstract：:It has been suggested that DNA organized into replication foci during S-phase remains stably aggregated in non-S-phase cells and that these stable aggregates provide fundamental units of nuclear or chromosome architecture [C. Meng and R. Berezney (1991) J. Cell Biol. 115, 95a; E. Sparvoli et al. (1994) J. Cell Sci. 10...

journal_title：Experimental cell research

authors： Zink D,Bornfleth H,Visser A,Cremer C,Cremer T

更新日期：1999-02-25 00:00:00

abstract：:Renal expression of the aldolase B isoenzyme and transcription factors previously shown to regulate the aldolase B gene promoter in the liver were analyzed in whole kidney, microdissected tubules, and the two PKSV-PCT and PKSV-PR proximal tubule cell lines derived from transgenic mice. Aldolase B gene expression appea...

journal_title：Experimental cell research

authors： Vallet V,Bens M,Antoine B,Levrat F,Miquerol L,Kahn A,Vandewalle A

更新日期：1995-02-01 00:00:00

abstract：:Vegetative amoebae of Dictyostelium discoideum (strain AX2) adhere to columns of hydrophobic beads (Bio-Beads SM-2) which have been coated with axenic growth medium. This binding is blocked by sodium azide and other inhibitors of aerobic respiration. Bound cells are not detached by lowering the temperature but they ca...

journal_title：Experimental cell research

authors： Glynn PJ,Clarke KR

更新日期：1984-05-01 00:00:00

abstract：:Most developing lymphocytes spontaneously die in the thymus during positive and negative selection of the T cell repertoire. By evaluating the expression of the proliferation antigens Ki-67 and PCNA, we demonstrated here that more than 95% of thymocytes are potentially proliferating. The coincidence within the same ce...

journal_title：Experimental cell research

authors： Pellicciari C,Bottone MG,Schaack V,Barni S,Manfredi AA

更新日期：1996-12-15 00:00:00

abstract：:UDP-glucose dehydrogenase (UGDH) catalyzes oxidation of UDP-glucose to yield UDP-glucuronic acid, a precursor of hyaluronic acid (HA) and other glycosaminoglycans (GAGs) in extracellular matrix. Although association of extracellular matrix with cell proliferation and migration has been well documented, the importance ...

journal_title：Experimental cell research

authors： Wang TP,Pan YR,Fu CY,Chang HY

更新日期：2010-10-15 00:00:00

abstract：:The Golgi apparatus undergoes extensive fragmentation during mitosis in animal cells. Protein kinases play a critical role during fragmentation of the Golgi apparatus. We reported here that Polo-like kinase 3 (Plk3) may be an important mediator during Golgi breakdown. Specifically, Plk3 was concentrated at the Golgi a...

journal_title：Experimental cell research

authors： Ruan Q,Wang Q,Xie S,Fang Y,Darzynkiewicz Z,Guan K,Jhanwar-Uniyal M,Dai W

更新日期：2004-03-10 00:00:00

abstract：:The mechanisms that structure the mammalian endoplasmic reticulum (ER) network are not fully understood. Here we show that salt extraction of semi-intact normal rat kidney (NRK) fibroblasts and subsequent incubation of the extracted cells with ATP resulted in dramatic ER network retraction. Under these conditions, add...

journal_title：Experimental cell research

authors： Baughman C,Morin-Leisk J,Lee T

更新日期：2008-08-15 00:00:00

abstract：:In studies of the ontogeny of fibroblast-epithelial interactions during late fetal lung rat lung development, we have identified two subpopulations of fibroblasts which differed in their ability to promote epithelial cell proliferation or differentiation. As glycosaminoglycans (GAGs) have been implicated in the regula...

journal_title：Experimental cell research

authors： Caniggia I,Tanswell K,Post M

更新日期：1992-10-01 00:00:00

abstract：:The histone 2A variant macroH2A1.2 is expressed in female and male mammals and is implicated in X-chromosome inactivation and autosomal gene silencing. In undifferentiated and early differentiating murine embryonic stem (ES) cells a cytosolic pool of macroH2A1.2 has recently been reported and found to be associated wi...

journal_title：Experimental cell research

authors： Mermoud JE,Tassin AM,Pehrson JR,Brockdorff N

更新日期：2001-08-15 00:00:00

abstract：:Integrin beta 4 subunit is present in association with alpha 6 chain on both normal and transformed epithelial cells. Recently alpha 6 beta 4 heterodimer was found on the endothelium of medium-sized blood vessels and on immature thymocytes. In this report we show, by Northern blotting, indirect immunofluorescence, imm...

journal_title：Experimental cell research

authors： Scardigli R,Soddu S,Falcioni R,Crescenzi M,Cimino L,Sacchi A

更新日期：1996-09-15 00:00:00

abstract：:We established a differentiation method for homogeneous α7 integrin-positive human skeletal muscle stem cell (α7(+)hSMSC)-derived osteoblast-like cells with bone morphogenetic protein (BMP)-2. To explore the early signaling cascade for osteoblastic differentiation, we examined the upregulation of autophagy-related gen...

journal_title：Experimental cell research

authors： Ozeki N,Mogi M,Hase N,Hiyama T,Yamaguchi H,Kawai R,Matsumoto T,Nakata K

更新日期：2016-09-10 00:00:00

abstract：:Products of the Neuregulin-1 (Nrg-1) gene, along with the ErbB family of receptor tyrosine kinases through which Nrg-1 ligands signal, play a critical role during cardiovascular development. Through studies of genetically manipulated mice, as well as studies in cells isolated from adult hearts, it appears that Nrg-1/E...

journal_title：Experimental cell research

authors： Pentassuglia L,Sawyer DB

更新日期：2009-02-15 00:00:00

abstract：:Skeletal muscle atrophy is a debilitating condition that can arise due to aging, cancer, corticosteroid use, and denervation. To better characterize the molecular genetic events of neurogenic atrophy, a previous study analyzed gene expression patterns in gastrocnemius muscle following sciatic nerve transection and fou...

journal_title：Experimental cell research

authors： Lynch SA,McLeod MA,Orsech HC,Cirelli AM,Waddell DS

更新日期：2019-10-15 00:00:00