The level of nerve growth factor (NGF) as a function of innervation. A correlation radio-immunoassay and bioassay study of the rat iris.

abstract：:Periosteal cells were enzymatically liberated from the tibiae of young chicks, introduced into cell culture, and allowed to reach confluence. The morphology of the cells gave the impression of a relatively homogeneous population of fibroblast-like cells. These cultured cells did not overtly express osteogenic or chond...

journal_title：Experimental cell research

authors： Nakahara H,Dennis JE,Bruder SP,Haynesworth SE,Lennon DP,Caplan AI

更新日期：1991-08-01 00:00:00

abstract：:DNA topoisomerase (topo) I plays an important role in DNA metabolism by relieving the torsional restraints of DNA topology through ATP-independent single-strand DNA breakage. In the present study, we expressed human topo I in HeLa cells by fusing it to enhanced green fluorescent protein (EGFP). The EGFP-topo I fusion ...

journal_title：Experimental cell research

authors： Mo YY,Wang P,Beck WT

更新日期：2000-05-01 00:00:00

abstract：:Rat thyroid differentiated cells (PC Cl 3) are an excellent model system with which to study the interaction between differentiation and cell transformation. We previously demonstrated that PC Cl 3 cells expressing the adenovirus E1A gene no longer depend on thyrotropin for growth and do not express thyroid differenti...

journal_title：Experimental cell research

authors： Iuliano R,Trapasso F,Stella A,Le Pera I,Melillo RM,Bruni P,Baldassarre G,Chiariotti L,Santoro M,Viglietto G,Fusco A

更新日期：2000-11-01 00:00:00

abstract：:Activation of mouse bone marrow-derived mast cells (BMMC) by thrombin (0.05-0.5 U/million cells) resulted in a concentration-dependent release of histamine, which levelled off by 0.1 U thrombin. Rat peritoneal mast cells (RMC) were not stimulated by thrombin, though in control experiments, both types of mast cells deg...

journal_title：Experimental cell research

authors： Razin E,Baranes D,Marx G

更新日期：1985-10-01 00:00:00

abstract：:Recruitment of mesenchymal stem cells (MSC) to tissue damages is a promising approach for in situ tissue regeneration. The physiological mechanisms and regulatory processes of MSC trafficking to injured tissue remain poorly understood. However, the pivotal role of chemokines in MSC recruitment has already been shown. ...

journal_title：Experimental cell research

authors： Binger T,Stich S,Andreas K,Kaps C,Sezer O,Notter M,Sittinger M,Ringe J

更新日期：2009-05-01 00:00:00

abstract：:Epidermal growth factor (EGF) and transforming growth factor-beta1 (TGF-beta1), upregulated in renal diseases, have a combinational effect on epithelial-mesenchymal transformation (EMT) of renal proximal tubular cells. The aim of this study was to examine the mechanism regarding the combinational effect of EGF and TGF...

journal_title：Experimental cell research

authors： Tian YC,Chen YC,Chang CT,Hung CC,Wu MS,Phillips A,Yang CW

更新日期：2007-07-01 00:00:00

abstract：:Skeletal muscle atrophy is a debilitating condition that can arise due to aging, cancer, corticosteroid use, and denervation. To better characterize the molecular genetic events of neurogenic atrophy, a previous study analyzed gene expression patterns in gastrocnemius muscle following sciatic nerve transection and fou...

journal_title：Experimental cell research

authors： Lynch SA,McLeod MA,Orsech HC,Cirelli AM,Waddell DS

更新日期：2019-10-15 00:00:00

abstract：:Microfilament-associated proteins and membrane-microfilament interactions are being investigated in microvilli isolated from 13,762 rat mammary ascites tumor cells. "Phalloidin shift" analyses on velocity sedimentation gradients of Triton X-100 extracts of [3H]-glucosamine-labeled microvilli identified a 120-kDa cell-...

journal_title：Experimental cell research

authors： Vanderpuye OA,Carraway CA,Carraway KL

更新日期：1988-10-01 00:00:00

abstract：:We report that a fatty acid auxotroph of Tetrahymena thermophila (RH179E1) fails to mate, yet retains the ability to co-stimulate normal cells unidirectionally. Thus, co-stimulation can be analyzed experimentally in the absence of pair formation. We show that the co-stimulation of normal cells of one mating type is su...

journal_title：Experimental cell research

authors： Katz M,Conner RL,Baum MP,Orias E

更新日期：1987-03-01 00:00:00

abstract：:Tumor angiogenesis and immune response have in common to be cell recognition mechanisms, which are based on specific adhesion molecules and dependent on nitric oxide (NO(•)). The aim of the present study is to deepen the mechanisms of angiogenesis and inflammation regulation by NO(•) to find out the molecular regulati...

journal_title：Experimental cell research

authors： Carreau A,Kieda C,Grillon C

更新日期：2011-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) results from the uncontrolled proliferation and accumulation of B-1 cells, many of which demonstrate self-reactivity. The response of B-1 cells to mitogen after undergoing malignant transformation is still unclear. Using our established malignant B-1 cell lines derived from the NZB m...

journal_title：Experimental cell research

authors： Zhang M,Chong SY,Raveche ES

更新日期：2001-04-01 00:00:00

abstract：:In primary cultures of ovine thyroid cells, TSH induced the expression of several differentiated functions including the formation of follicles, and synthesis and storage of iodinated thyroglobulin in the follicular lumen. In the present report, these follicles were shown by transmission (TEM) and scanning electron mi...

journal_title：Experimental cell research

authors： Mak WW,Errick JE,Chan RC,Eggo MC,Burrow GN

更新日期：1986-06-01 00:00:00

abstract：:p75NTR is a member of the tumor necrosis superfamily of proteins which is variably associated with induction of apoptosis and proliferation. Cyclin D2 is one of the mediators of cellular progression through G1 phase of the cell cycle. The present study demonstrates the inverse relationship between expression of cyclin...

journal_title：Experimental cell research

authors： Fritz MD,Mirnics ZK,Nylander KD,Schor NF

更新日期：2006-10-15 00:00:00

abstract：:TIP48 is a highly conserved eukaryotic AAA+ protein which is an essential cofactor for several complexes involved in chromatin acetylation and remodeling, transcriptional and developmental regulation and nucleolar organization and trafficking. We show that TIP48 abundance in HeLa cells did not change during the cell c...

journal_title：Experimental cell research

authors： Sigala B,Edwards M,Puri T,Tsaneva IR

更新日期：2005-11-01 00:00:00

abstract：:Epithelial ovarian cancer is the most common form of gynaecological malignancy. This lethal disease is thought to arise in ovarian surface epithelial (OSE) cells. The biology of these cells is not well understood, due to the limited amount of tissue that can be obtained from a single biopsy and their limited life span...

journal_title：Experimental cell research

authors： Davies BR,Steele IA,Edmondson RJ,Zwolinski SA,Saretzki G,von Zglinicki T,O'Hare MJ

更新日期：2003-08-15 00:00:00

abstract：:It is known that freshly dissociated thyroid cell clusters form follicles in suspension culture. Thyroid epithelial cell lines, grown for many generations in vitro, fail to show colloid-containing lumina when cultured as monolayers. Several thyroid cell lines, some transformed, have been tested with respect to their a...

journal_title：Experimental cell research

authors： Nitsch L,Tacchetti C,Tramontano D,Ambesi-Impiombato FS

更新日期：1984-05-01 00:00:00

abstract：:Previous studies have shown that centrosome position and structure can be influenced by actin filaments, that centrosomes can influence actin organization, and that an actin homologue is associated with centrosomes. Such observations suggest the existence of connections between centrosomes and actin networks. In keepi...

journal_title：Experimental cell research

authors： Chevrier V,Paintrand M,Koteliansky V,Block MR,Job D

更新日期：1995-08-01 00:00:00

abstract：:The basic helix-loop-helix/leucine zipper (bHLH/ZIP) microphthalmia-associated transcription factor (MITF) regulates transcription of genes encoding enzymes essential for melanin biosynthesis in melanocytes and retinal pigmented epithelial cells. To determine how MITF activity is regulated, we used the yeast two-hybri...

journal_title：Experimental cell research

authors： Xu W,Gong L,Haddad MM,Bischof O,Campisi J,Yeh ET,Medrano EE

更新日期：2000-03-15 00:00:00

abstract：:The actin interaction of coronin 3 has been mainly documented by in vitro experiments. Here, we discuss coronin 3 properties in the light of new structural information and focus on assays that reflect in vivo roles of coronin 3 and its impact on F-actin-associated functions. Using GFP-tagged coronin 3 fusion proteins ...

journal_title：Experimental cell research

authors： Rosentreter A,Hofmann A,Xavier CP,Stumpf M,Noegel AA,Clemen CS

更新日期：2007-03-10 00:00:00

abstract：:We studied the expression of FREK (fibroblast growth factor receptor-like embryonic kinase), a new receptor recently cloned from quail embryo, during the differentiation of skeletal muscle satellite cells and epiphyseal growth-plate chondrocytes. Although FREK mRNA was expressed in both cell types, satellite cells exp...

journal_title：Experimental cell research

authors： Halevy O,Monsonego E,Marcelle C,Hodik V,Mett A,Pines M

更新日期：1994-06-01 00:00:00

abstract：:Various cell adhesion molecules mediate the diverse functions of the vascular endothelium, such as cell adhesion, neutrophil migration, and angiogenesis. In order to identify cell adhesion molecules important for angiogenesis, we used an in vitro model (Chalupowicz, Chowdhury, Bach, Barsigian, and Martinez, J. Cell Bi...

journal_title：Experimental cell research

authors： Bach TL,Barsigian C,Chalupowicz DG,Busler D,Yaen CH,Grant DS,Martinez J

更新日期：1998-02-01 00:00:00

abstract：:A combination of broadly expressed transcriptional activators and spatially restricted repressors are used to pattern embryos into cells of different fate. Transcriptional co-regulators are essential mediators of transcription factor function, and contribute to selective transcriptional responses in embryo development...

journal_title：Experimental cell research

authors： Mannervik M

更新日期：2014-02-01 00:00:00

abstract：:Alternative splicing is an important mechanism that can disrupt cell cycle control resulting in tumorigenesis. Although many alterations of Transforming Growth Factor Beta (TGFβ) signaling are reported in cancers, the role of splice aberrations in destabilizing this signaling is the least understood mechanism. In this...

journal_title：Experimental cell research

authors： Sivadas VP,Gulati S,Varghese BT,Balan A,Kannan S

更新日期：2014-09-10 00:00:00

abstract：:Autophagy is the principle pathway within cells involved in clearing damaged proteins and organelles. Therefore autophagy is necessary to maintain the turnover balance of peptides and homoeostasis. Autophagy occurs at basal levels under normal conditions but can be upregulated by chemical inducers or stress conditions...

journal_title：Experimental cell research

authors： Ganesan S,Moussavi Nik SH,Newman M,Lardelli M

更新日期：2014-10-15 00:00:00

abstract：:The growth of malignant melanoma cells is inhibited by 12-O-tetradecanoylphorbol-13-acetate (TPA) while the growth of normal melanocytes is stimulated. We previously demonstrated that TPA inhibits the growth of Demel melanoma cells and leads to arrest at both at the G1/S and G2/M cell cycle transitions. To investigate...

journal_title：Experimental cell research

authors： Coppock DL,Buffolino P,Kopman C,Nathanson L

更新日期：1995-11-01 00:00:00

abstract：:Chronic high glucose levels lead to the formation of advanced glycation end-products (AGEs) as well as AGE precursors, such as methylglyoxal (MG) and glyoxal, via non-enzymatic glycation reactions in patients with diabetic mellitus. Glyoxalase 1 (GLO-1) detoxifies reactive dicarbonyls that form AGEs. To investigate th...

journal_title：Experimental cell research

authors： Kim KM,Kim YS,Jung DH,Lee J,Kim JS

更新日期：2012-01-15 00:00:00

abstract：:We have studied the morphological alterations of the lysosomal compartment in rat hepatocytes following intraperitoneal administration of leupeptin, using electron microscopy and cytochemical techniques. At 30 min after the injection, autophagic vacuoles (autophagosomes and autolysosomes), containing cytoplasmic organ...

journal_title：Experimental cell research

authors： Ishikawa T,Furuno K,Kato K

更新日期：1983-03-01 00:00:00

abstract：:Our previous studies have showed that tumor-derived autophagosomes (termed "DRibbles") induce B cell activation, resulting in antibody production and cytokine secretion. Unexpectedly, we found that unfractionated splenocytes produced a higher level of antibody and cytokine than that of purified B cells. In the current...

journal_title：Experimental cell research

authors： Zhou M,Li W,Wen Z,Sheng Y,Ren H,Dong H,Cao M,Hu HM,Wang LX

更新日期：2015-02-15 00:00:00

abstract：:High glucose concentrations associated with diabetes have been shown to cause the nonenzymatic modification of proteins. Reducing sugars covalently bind to free amine groups, undergo Amadori rearrangements, and crosslink with other glucose-modified proteins. Crosslinking of type I collagen by incubation with different...

journal_title：Experimental cell research

authors： Howard EW,Benton R,Ahern-Moore J,Tomasek JJ

更新日期：1996-10-10 00:00:00

abstract：:Tumor cell adhesion within host organ microvasculature, its stabilization and invasion into host organ parenchyma appear to be important steps during formation of distant metastasis. These interactions of circulating tumor cells with the host organs occur in the presence of fluid shear forces and soluble and cellular ...

journal_title：Experimental cell research

authors： Korb T,Schlüter K,Enns A,Spiegel HU,Senninger N,Nicolson GL,Haier J

更新日期：2004-09-10 00:00:00