Coronin 3 involvement in F-actin-dependent processes at the cell cortex.

abstract：:Transepithelial resistance (TER) measurement has often been used to study the paracellular transport properties of epithelia grown on permeable filters, especially the barrier function of tight junctions. However, the TER value includes another source, the resistance caused by cell-substrate contact, that may give ris...

journal_title：Experimental cell research

authors： Lo CM,Keese CR,Giaever I

更新日期：1999-08-01 00:00:00

abstract：:A sufficient supply molecular oxygen is essential for the maintenance of physiologic metabolism and bioenergetic homeostasis for most metazoans. For this reason, mechanisms have evolved for eukaryotic cells to adapt to conditions where oxygen demand exceeds supply (hypoxia). These mechanisms rely on the modification o...

journal_title：Experimental cell research

authors： Cavadas MAS,Cheong A,Taylor CT

更新日期：2017-07-15 00:00:00

abstract：:Pancreatic cancer is characterized by aggressive local invasion and early metastasis formation. Active migration of the pancreatic cancer cells is essential for these processes. We have shown previously that the pancreatic cancer cells lines CFPAC1 and IMIM-PC2 show high migratory activity, and we have investigated he...

journal_title：Experimental cell research

authors： Stock AM,Hahn SA,Troost G,Niggemann B,Zänker KS,Entschladen F

更新日期：2014-08-15 00:00:00

abstract：:Cell-CAM 105 is an integral cell surface glycoprotein that is involved in cell-cell adhesion of adult rat hepatocytes in vitro. In the present report we used a radio-immunoassay, a quantitative immunoblotting technique and immunofluorescence microscopy to investigate the expression of cell-CAM 105 in fetal and regener...

journal_title：Experimental cell research

authors： Odin P,Obrink B

更新日期：1986-05-01 00:00:00

abstract：:The radula of the limpet, Cellana toreuma, consists of a continuous series of teeth in various stages of iron biomineralization. The major iron-binding protein of the limpet's iron-containing granule (siderosome) has been purified and identified as ferritin. Limpet ferritin has a M(r) of 575 kDa and can be resolved in...

journal_title：Experimental cell research

authors： Lu HK,Huang CM,Li CW

更新日期：1995-07-01 00:00:00

abstract：:This study shows the sensitivity of insulin-secreting RIN m5F cells to undergoing apoptosis without modifying intracellular free calcium concentrations. The culture of cells in the absence of serum during 6 h failed to produce spontaneous DNA fragmentation. However, when cultures were carried out in the presence of th...

journal_title：Experimental cell research

authors： Sánchez-Margalet V,Lucas M,Solano F,Goberna R

更新日期：1993-11-01 00:00:00

abstract：:Two genes, KIN1 and KIN2, were isolated in Saccharomyces cerevisiae by their homology to the protein kinase family of viral oncogenes. In previous studies, we identified the yeast KIN1 gene product (pp145KIN1) and KIN2 gene product (pp145KIN2) as 145 kDa phosphoproteins with serine/threonine protein kinase activity. W...

journal_title：Experimental cell research

authors： Tibbetts M,Donovan M,Roe S,Stiltner AM,Hammond CI

更新日期：1994-07-01 00:00:00

abstract：:Developmental studies have demonstrated that the vascular smooth muscle cells (VSMC) present within the elastic arteries are differentiated from two definitive origins, the neural crest and the mesoderm. Cells from these distinct progenitors differ in their ability to determine long-range spatial order of the extracel...

journal_title：Experimental cell research

authors： Thieszen SL,Dalton M,Gadson PF,Patterson E,Rosenquist TH

更新日期：1996-08-25 00:00:00

abstract：:DNA damage caused by alkylating agents results in a G2 checkpoint arrest. DNA mismatch repair (MMR) deficient cells are resistant to killing by alkylating agents and are unable to arrest the cell cycle in G2 phase after alkylation damage. We investigated the response of two MMR-deficient prostate cancer cell lines DU1...

journal_title：Experimental cell research

authors： Rasmussen LJ,Rasmussen M,Lützen A,Bisgaard HC,Singh KK

更新日期：2000-05-25 00:00:00

abstract：:The protein tyrosine kinase Ack1 has been linked to cancer when over-expressed. Ack1 has also been suggested to function in clathrin-mediated endocytosis and in down-regulation of the epidermal growth factor (EGF) receptor (EGFR). We have studied the intracellular localization of over-expressed Ack1 and found that Ack...

journal_title：Experimental cell research

authors： Grøvdal LM,Johannessen LE,Rødland MS,Madshus IH,Stang E

更新日期：2008-04-01 00:00:00

abstract：:Nucleotide sugar transporters play a central role in the process of glycosylation. They are responsible for the translocation of nucleotide sugars from the cytosol, their site of synthesis, into the Golgi apparatus where the activated sugars serve as substrates for a variety of glycosyltransferases. We and others have...

journal_title：Experimental cell research

authors： Lühn K,Laskowska A,Pielage J,Klämbt C,Ipe U,Vestweber D,Wild MK

更新日期：2004-12-10 00:00:00

abstract：:Mitochondrial DNA (mtDNA) is a multicopy, maternally inherited, genome. Individuals frequently carry a mixture of genetically distinct mtDNA molecules whose proportions may vary between sexual generations or among tissues from the same individual. Analyses of the genetic composition of mitochondria have previously rel...

journal_title：Experimental cell research

authors： Cavelier L,Johannisson A,Gyllensten U

更新日期：2000-08-25 00:00:00

abstract：:Proliferation of human B- and T-lymphoid cell lines including Raji and Akata cells was found to be arrested at the G1 stage in the cell cycle by dimethyl sulfoxide (DMSO). The G1 arrest by DMSO occurred gradually and was completed within 96 h after addition of 1.5% DMSO concomitantly with a decrease in growth rate. Pr...

journal_title：Experimental cell research

authors： Sawai M,Takase K,Teraoka H,Tsukada K

更新日期：1990-03-01 00:00:00

abstract：:Epithelial ovarian cancer is the most common form of gynaecological malignancy. This lethal disease is thought to arise in ovarian surface epithelial (OSE) cells. The biology of these cells is not well understood, due to the limited amount of tissue that can be obtained from a single biopsy and their limited life span...

journal_title：Experimental cell research

authors： Davies BR,Steele IA,Edmondson RJ,Zwolinski SA,Saretzki G,von Zglinicki T,O'Hare MJ

更新日期：2003-08-15 00:00:00

abstract：:We present evidence for the possible involvement of both the RB and p53 proteins in the regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-antigen become senescent following the de-induction of T-antigen. Plasmids expressing an alternative source of intact T-antigen restore prol...

journal_title：Experimental cell research

authors： Shay JW,Pereira-Smith OM,Wright WE

更新日期：1991-09-01 00:00:00

abstract：:The C6 rat glioma cell line is shown to consist of a mixed population of cells which either contain vimentin (80% of the cells) or completely lack any cytoplasmic intermediate filament (IF) proteins. Subclones could be established with both phenotypes, indicating that these IF protein expression patterns represent sta...

journal_title：Experimental cell research

authors： Röser K,Bohn W,Giese G,Mannweiler K

更新日期：1991-12-01 00:00:00

abstract：:Colon cancer shows characteristics of metastasis, which is associated with angiogenesis. Increasing evidence highlights long non-coding RNAs (lncRNAs) as important participants in angiogenesis of cancers, including colon cancer. Hence, this study investigated the role of HNF1A-AS1 in angiogenesis of colon cancer. RT-q...

journal_title：Experimental cell research

authors： Wu J,Meng X,Jia Y,Chai J,Wang J,Xue X,Dang T

更新日期：2020-08-15 00:00:00

abstract：:The p53-regulated stress-inducible gene GADD45 has been shown to participate in cellular response to DNA damage, including cell cycle checkpoint, apoptosis, and DNA repair. However, the regulation of GADD45 expression is complex and may involve both p53-dependent and -independent pathways. Recent findings have demonst...

journal_title：Experimental cell research

authors： Tong T,Fan W,Zhao H,Jin S,Fan F,Blanck P,Alomo I,Rajasekaran B,Liu Y,Holbrook NJ,Zhan Q

更新日期：2001-09-10 00:00:00

abstract：:Analyses of mice with targeted deletions in the genes for alpha3 and beta1 integrin suggest that the alpha3beta1 integrin heterodimer likely determines the organization of the extracellular matrix within the basement membrane of skin. Here we tested this hypothesis using keratinocytes derived from alpha3 integrin-null...

journal_title：Experimental cell research

authors： deHart GW,Healy KE,Jones JC

更新日期：2003-02-01 00:00:00

abstract：:Tumor hypoxia correlates to aggressive disease, and while this is explained by a variety of factors, one clue to understand this phenomena was the finding that hypoxia induces a de-differentiated, stem cell-like phenotype in neuroblastoma and breast tumor cells. The hypoxia inducible transcription factors (HIFs) are r...

journal_title：Experimental cell research

authors： Mohlin S,Wigerup C,Jögi A,Påhlman S

更新日期：2017-07-15 00:00:00

abstract：:DNA topoisomerase II (topo II) is the target of many anticancer drugs and is often altered in drug-resistant cell lines. In some tumor cell lines truncated isoforms of topo IIalpha are localized to the cytoplasm. To study the localization and function of individual enzyme domains, we have epitope-tagged several fragme...

journal_title：Experimental cell research

authors： Soltermann A,Ernst A,Leroy D,Stahel RA,Gasser SM

更新日期：1999-06-15 00:00:00

abstract：:Human PHA-stimulated mononuclear cells produce a factor which inhibits synovial cell collagen and non-collagen protein synthesis, whereas it enhances hyaluronic acid (HA) production. Indomethacin (10(-4)-10(-6) M), a cyclo-oxygenase inhibitor, suppresses this effect, suggesting that the mechanism is prostaglandin-medi...

journal_title：Experimental cell research

authors： Pujol JP,Penfornis H,Arenzana-Seisdedos F,Bocquet J,Farjanel J,Rattner A,Brisset M,Virelizier JL,Beliard R,Loyau G

更新日期：1985-05-01 00:00:00

abstract：:Drosophila sHSPs (small heat shock proteins) are expressed in the absence of stress in specific regions of the central nervous system and in gonads of young adults flies. In these two organs, the sHSPs show a cell-specific and developmental stage-specific pattern of expression suggesting distinct regulation and functi...

journal_title：Experimental cell research

authors： Marin R,Landry J,Tanguay RM

更新日期：1996-02-25 00:00:00

abstract：:Mechanical stress is an important regulator of chondrocyte functions but the mechanisms by which chondrocytes sense mechanical signals are unknown. Receptors for matrix molecules are likely involved in the mechanical signaling. In the first part of this study we identified integrins with affinity for the cartilage-spe...

journal_title：Experimental cell research

authors： Holmvall K,Camper L,Johansson S,Kimura JH,Lundgren-Akerlund E

更新日期：1995-12-01 00:00:00

abstract：:The phosphorylation state of the CD18-chain of beta 2-integrins have been shown not to mediate changes in the avidity of these receptors (i.e., inside-out signaling); however, no alternative functional significance has been proposed. Our study focused on how changes in the phosphorylation state of beta 2-integrin-rece...

journal_title：Experimental cell research

authors： Hellberg C,Eierman D,Sjölander A,Andersson T

更新日期：1995-03-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a pleiotropic cytokine promoting proliferation, migration and survival in several cell types. HGF and its cognate receptor c-Met are expressed in cardiac cells during early cardiogenesis, but data concerning its role in cardiac differentiation of embryonic stem cells (ESCs) and the un...

journal_title：Experimental cell research

authors： Roggia C,Ukena C,Böhm M,Kilter H

更新日期：2007-03-10 00:00:00

abstract：:Bone morphogenetic protein (BMP), a member of the TGF-beta superfamily, is involved in development, morphogenesis, cell proliferation and apoptosis. Dysregulation of BMP signaling has been suggested in tumorigenesis. In an analysis of human colon normal mucosa and tumors at different stages by immunohistochemistry, we...

journal_title：Experimental cell research

authors： Deng H,Makizumi R,Ravikumar TS,Dong H,Yang W,Yang WL

更新日期：2007-03-10 00:00:00

abstract：:Tunneling nanotubes (TnTs) are long, non-adherent, actin-based cellular extensions that act as conduits for transport of cellular cargo between connected cells. The mechanisms of nanotube formation and the effects of the tumor microenvironment and cellular signals on TnT formation are unknown. In the present study, we...

journal_title：Experimental cell research

authors： Thayanithy V,Babatunde V,Dickson EL,Wong P,Oh S,Ke X,Barlas A,Fujisawa S,Romin Y,Moreira AL,Downey RJ,Steer CJ,Subramanian S,Manova-Todorova K,Moore MAS,Lou E

更新日期：2014-04-15 00:00:00

abstract：:Interleukin 3 (IL-3) stimulates the growth of various types of hemopoietic progenitors. In vitro, survival of a series of murine cell lines derived from either neoplastic or nonneoplastic hemopoietic tissue shows a strict IL-3 dependence. In order to test the implication of energy metabolism in this dependence as clai...

journal_title：Experimental cell research

authors： Reisbach G,Ellwart J,Dörmer P

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Emerging studies demonstrate that long noncoding RNAs (lncRNAs) play crucial roles in hepatocarcinogenesis through various mechanisms. LncRNA CCAT2 was a newly discovered lncRNA and amplified in several cancers. However, the mechanisms involved in function of CCAT2 in hepatocellular carcinoma (HCC) remain to...

journal_title：Experimental cell research

authors： Liu Y,Wang D,Li Y,Yan S,Dang H,Yue H,Ling J,Chen F,Zhao Y,Gou L,Tang P,Huang A,Tang H

更新日期：2019-06-01 00:00:00